Mast Cell News and Research

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Mast cells in synovial tissue may explain why women report worse osteoarthritis pain than men

Investigators at Hospital for Special Surgery (HSS) have discovered that at the time of total knee replacement, women have significantly increased levels of immune cells called mast cells in synovial tissue surrounding the knee joint than men.

14 Nov 2022

Study explores the potential use of anti-thymic stromal lymphopoietin monoclonal antibody as an adjuvant in allergic immunotherapy

A new study investigated the impact of a monoclonal anti-thymic stromal lymphopoietin (TSLP) antibody on subcutaneous allergen immunotherapy (SCIT) efficacy among patients with allergic rhinitis.

3 Nov 2022

Stanford researchers discover a sustainable way to produce cancer-fighting compound in the lab

Stanford University researchers have discovered a rapid and sustainable way to synthetically produce a promising cancer-fighting compound right in the lab.

3 Oct 2022

Novel peanut-specific human IgE monoclonal antibodies may uncover new therapeutic targets for peanut allergy

A recent Frontiers in Immunology journal study by University of North Carolina at Chapel Hill and Vanderbilt University researchers has created an in vitro system to determine potential therapeutics targeting sensitized effector cells based on human, allergen-specific, Immunoglobulin E (IgE) monoclonal antibodies (mAbs).

2 Oct 2022

Gut bacterial 'super-producer' of histamine can cause pain flare-ups in some IBS patients

Researchers from McMaster University and Queen's University have discovered a gut bacterial 'super-producer' of histamine that can cause pain flare-ups in some patients with irritable bowel syndrome (IBS).

27 Jul 2022

New therapeutic avoids major allergic reactions while maintaining therapeutic activity

Several years ago, a promising therapeutic using stem cell factor (SCF) emerged that could potentially treat a variety of ailments, such as ischemia, heart attack, stroke and radiation exposure.

8 Jun 2022

AI model predicts postoperative recurrence of Crohn disease with high accuracy

Using an artificial intelligence (AI) tool that emulates how humans visualize and is trained to recognize and classify images, investigators constructed a model that predicts the postoperative recurrence of Crohn disease with high accuracy by evaluating histological images.

10 May 2022

New test greatly simplifies the diagnosis of allergies

Although allergies are widespread, their diagnosis is complex and, depending on the type of allergy, the prospects of success with therapy are not always clear.

21 Mar 2022

NCCN publishes new resources for treating rare tumor types

The National Comprehensive Cancer Network - an alliance of leading cancer centers - today announced the publication of new NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Ampullary Adenocarcinoma.

9 Mar 2022

Activated mast cell disorders potentially linked to SARS-CoV-2 immunity

An intriguing new study reports a year-long study in patients with cMCADs from all over France.

7 Sep 2021

Federal vaccine program hasn’t helped those whose lives were altered by covid shot

Angela Marie Wulbrecht jumped at the first chance to get a covid-19 vaccine, driving three hours from her Santa Rosa, California, home to a mass-vaccination site on Jan. 19.

18 Aug 2021

Potential new treatment for mast cell cancers reduces tumor size and prevents organ infiltration

A potential new treatment for mast cell cancers reduces the number of mast cells by "mutating" the messenger RNA (mRNA) before it can deliver instructions for manufacturing the gene responsible for cell proliferation.

10 Aug 2021

Existing drug may be effective in treating SARS-CoV-2

Scientists from the University of Chicago have found that the drug masitinib may be effective in treating COVID-19.

2 Aug 2021

Existing drug may be effective in treating COVID-19

A new University of Chicago study has found that the drug masitinib may be effective in treating COVID-19.

21 Jul 2021

Mast cell activation may underlie inflammation in severe COVID-19

A new preprint research paper posted to the medRxiv* server points to mast cells as major culprits in the etiology of severe and critical COVID-19. This could suggest suitable therapeutic and preventive interventions to reduce the morbidity and mortality of this viral illness.

3 Jun 2021

Mast Cell News and Research

Mast cells in synovial tissue may explain why women report worse osteoarthritis pain than men

Study explores the potential use of anti-thymic stromal lymphopoietin monoclonal antibody as an adjuvant in allergic immunotherapy

Stanford researchers discover a sustainable way to produce cancer-fighting compound in the lab

Novel peanut-specific human IgE monoclonal antibodies may uncover new therapeutic targets for peanut allergy

Gut bacterial 'super-producer' of histamine can cause pain flare-ups in some IBS patients

New therapeutic avoids major allergic reactions while maintaining therapeutic activity

AI model predicts postoperative recurrence of Crohn disease with high accuracy

New test greatly simplifies the diagnosis of allergies

NCCN publishes new resources for treating rare tumor types

Activated mast cell disorders potentially linked to SARS-CoV-2 immunity

Federal vaccine program hasn’t helped those whose lives were altered by covid shot

Potential new treatment for mast cell cancers reduces tumor size and prevents organ infiltration

Existing drug may be effective in treating SARS-CoV-2

Existing drug may be effective in treating COVID-19

Mast cell activation may underlie inflammation in severe COVID-19

People with venom allergies are more likely to have bone marrow disorder

Long COVID also affects children, study finds

Michigan Medicine to kick off first national study on allergic reactions to COVID-19 vaccines

NIH-funded clinical trial begins study of systemic allergic reactions to COVID-19 vaccines

Researchers discover new mechanism that contributes to airway hyperresponsiveness in asthma

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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