Oncogene News and Research

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An oncogene is a gene that, when mutated or expressed at high levels, helps turn a normal cell into a tumor cell.

Study explores how a familiar spice tackles the toughest cancer cells

Researchers found that clinically achievable doses of curcumin, the active compound in turmeric, target and suppress colorectal cancer stem-like cells, especially in early adenomas. Curcumin shifts these cells toward differentiation, delays tumor growth in mice, and may offer a safe preventive strategy.

27 Jun 2025

Study reveals how FOXA1 mutations drive prostate cancer and therapy resistance

A new study from the University of Michigan Rogel Health Cancer Center, published in Science, sheds light on how two distinct classes of mutations in the FOXA1 gene-commonly altered in prostate cancer-drive tumor initiation formation and therapeutic resistance.

26 Jun 2025

New KRAS mutation discovery opens door to targeted colon cancer therapies

Scientists at Fox Chase Cancer Center have identified a mutation in a common oncogene - a gene that can cause cancer - that may play an important role in colon cancer. Researchers also showed how this mutation could be targeted therapeutically.

24 Jun 2025

Exploring the dual role of microRNA-223 in hepatic fibrosis

Announcing a new article publication for BIO Integration journal. Liver fibrosis is caused by excessive extracellular matrix accumulation, which in turn is driven by activation of hepatic stellate cells.

19 Jun 2025

c-Fos exhibits a dual role in memory formation and Alzheimer's disease

Immediate-early genes (IEGs), including c-Fos, are integral to the brain's response to stimuli. Initially identified as a proto-oncogene, c-Fos is essential for neural activity, synaptic plasticity, and stress responses.

14 Jun 2025

Mapping genetic activity offers new clues for personalized cancer treatment

City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the U.S. with its National Medical Center named top 5 in the nation for cancer by U.S. News & World Report, co-led the first study to demonstrate that characterizing genetic material near chromosomes forecasts how mutated, cancer-causing genes reengineer DNA and alter the tumor microenvironment.

13 Jun 2025

Necrosis may hold the key to unlocking longevity and space health solutions

The process of necrosis, a form of cell death, may represent one of the most promising ways to change the course of human aging, disease and even space travel, according to a new study from researchers at UCL, drug discovery company LinkGevity and the European Space Agency (ESA).

29 May 2025

Study reveals dual role of TEAD proteins in neural development

Scientists at St. Jude Children’s Research Hospital found that, in neural development, the same set of proteins involved in cellular self-renewal can also facilitate differentiation with the right binding partner.

20 May 2025

Two genetic variants linked to breast cancer discovered in black South African women

Genetic factors contribute to some 30% of breast cancer cases in SA, necessitating investment in genomic research in African contexts.

15 May 2025

Review spotlights MYC as a multidimensional therapeutic target in cancer

A new review in Genes and Diseases explores the central role of MYC, a master regulatory protein, in the development and progression of cancer, spotlighting its potential as a multidimensional therapeutic target.

12 May 2025

Targeting METTL3 may offer new hope for oral cancer treatment

A new research paper was published in Oncotarget, Volume 16, on May 8, 2025, titled "METTL3 promotes oral squamous cell carcinoma by regulating miR-146a-5p/SMAD4 axis."

11 May 2025

Researchers trace origins of aggressive childhood brain tumors

Medulloblastoma is one of the most common malignant tumors of the central nervous system (CNS) in children and adolescents. It develops in the area of the cerebellum, which is responsible for movement coordination, among other things.

7 May 2025

Precision medicine approach improves treatment for soft tissue sarcomas

A study conducted by researchers from the Agency for Science, Technology and Research (A*STAR), National Cancer Centre Singapore (NCCS) and National University of Singapore (NUS), in collaboration with biotech company, KYAN Technologies, has demonstrated that a precision medicine approach improves treatment selection for patients with soft tissue sarcomas (STS) in a clinical setting.

7 May 2025

Can folic acid prevent or promote breast cancer? It depends on dose and DNA

Folic acid plays a dual role in breast cancer depending on dose and context. While moderate intake may reduce risk, high levels or genetic variants disrupting metabolism may promote tumor progression via altered DNA methylation.

30 Apr 2025

FOXR2 activation found in multiple pediatric brain tumor types

Physicians classify brain tumors and determine treatment options, in part, by the genes they express. According to World Health Organization standards, the abnormal activation of oncogene FOXR2 only occurs in central nervous system (CNS) neuroblastoma, but that may not be true.

16 Apr 2025

Researchers analyze the mutational landscape of TMB-high colorectal cancer tumors

Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer-related deaths worldwide.

15 Apr 2025

New study connects parasitic disease to genetic changes in the cervical lining

New research has revealed that Schistosoma haematobium (S. haematobium), a parasitic infection affecting millions globally, can trigger cancer-related gene activity in the cervical lining, with changes becoming even more pronounced after treatment.

12 Apr 2025

Dynamic BH3 profiling offers personalized lung cancer therapies

Eighty-five percent of diagnosed cases of lung cancer are non-small cell lung cancer (NSCLC). In this group, 5% of patients show molecular alterations in the ALK gene involved in cell multiplication.

9 Apr 2025

New molecular target identified for pancreatic cancer treatment

Researchers at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the U.S. with its National Medical Center named top 5 in the nation for cancer by U.S. News & World Report, have identified a new molecular target for treating pancreatic cancer, reports a Gastroenterology study published today.

8 Apr 2025

Mouse and organoid models reveal FGFR2's role in pancreatic cancer aggression and interception

Pancreatic cancer is projected to become the second-deadliest cancer by 2030. By the time it's diagnosed, it's often difficult to treat. So, for both individual patients and the general population, fighting pancreatic cancer can feel like a race against time. Cold Spring Harbor Laboratory (CSHL) Professor and Cancer Center Director David Tuveson offers a telling analogy:

3 Apr 2025