Ribosome News and Research

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Bacteria modify their ribosomes in response to the antibiotics

Bacteria modify their ribosomes when exposed to widely used antibiotics, according to research published today in Nature Communications. The subtle changes might be enough to alter the binding site of drug targets and constitute a possible new mechanism of antibiotic resistance.

29 Nov 2024

RNA enzyme found key to heart cell energy shift after birth

Researchers investigate the influence of Mettl1 on energy metabolism and the maturation of heart cells after birth.

29 Nov 2024

Advanced microscopy reveals how ribosomes attach to mRNA for protein synthesis

Within a cell, DNA carries the genetic code for building proteins. To build proteins, the cell makes a copy of DNA, called mRNA.

28 Nov 2024

Scientists uncover a previously unrecognized tumor suppression mechanism

There are processes in the human body that can suppress the growth and proliferation of cancer cells. These mechanisms, including those involving the tumor suppressor protein p53, are widely studied due to their critical role in disease.

12 Nov 2024

P-stalk ribosomes identified as key regulators of immune evasion in cancer

Research uncovers how P-stalk ribosomes regulate cytokine responses, driving immune evasion in tumors across multiple cancer types. It offers new insights into post-translational mechanisms influencing immunotherapy success.

23 Oct 2024

Cancer cells use ribosomes to evade immune detection, study shows

The protein factories of our cells are much more diverse than we thought they were. Scientists from the Netherlands Cancer Institute have now shown that cancer cells can use these so-called ribosomes to boost their invisibility cloak, helping them hide from the immune system.

21 Oct 2024

New study reveals molecular mechanism in Alzheimer's disease

A research team at the Institute of Neurosciences of the University of Barcelona (UBneuro) has led a study describing a new molecular mechanism that affects RNA processing and alters the process of protein synthesis in the brains of Alzheimer's patients.

18 Oct 2024

New insights on 5-fluorouracil's mechanism in different cancers

Study reveals the drug, 5-fluorouracil, acts differently in different types of cancer — a finding that could help researchers design better drug combinations.

7 Oct 2024

New insights into lasso peptides offer promise for drug development

Lasso peptides are natural products made by bacteria. Their unusual lasso shape endows them with remarkable stability, protecting them from extreme conditions

20 Sep 2024

Discovery of cellular process could impact the understanding of cancer and aging

Researchers at UC Merced used fruit flies to uncover a cellular process common to many organisms that could dramatically impact the understanding of cancer and aging.

3 Sep 2024

Ribosomes in cells play a crucial role in protein folding

Scientists at UCL have discovered a novel role played by ribosomes during the folding of new proteins in cells, described in their paper in Nature.

7 Aug 2024

Challenging antibiotic resistance with dual-action macrolones

A new antibiotic that works by disrupting two different cellular targets would make it 100 million times more difficult for bacteria to evolve resistance, according to new research from the University of Illinois Chicago.

24 Jul 2024

New insights into modified nucleoside synthesis

The genetic information on DNA is transcribed into messenger RNA (mRNA) and translated to the amino acid sequence by transfer RNA (tRNA) on the ribosome. Modified nucleosides within RNA are involved in maintaining and regulating the protein synthesis system.

19 Jul 2024

New brain targets for GLP1-based obesity drugs may reduce weight without nausea

Researchers identified distinct hindbrain GLP1R neurons driving satiety and aversion, offering new targets for effective, side-effect-free obesity treatments.

14 Jul 2024

Ribosomes and ZAK protein spur the cell's initial response to UV radiation damage

In a recent study, researchers at Johns Hopkins Medicine suggest the cell's messenger RNA (mRNA) - the major translator and regulator of genetic material - along with a critical protein called ZAK, spur the cell's initial response to UV radiation damage and play a critical role in whether the cell lives or dies.

2 Jul 2024

Decoding the function of SRSF1 protein in RNA splicing and translation regulation

RNA transcription is the genomic process in which a cell produces a duplicate of a gene's DNA sequence.

30 May 2024

Study reveals impact of Mediator protein complex on cell division regulation

Researchers at Umeå University, Sweden, have discovered that how a special protein complex called the Mediator moves along genes in DNA may have an impact on how cells divide.

3 May 2024

Research provides first evidence for a possible cause of familial ALS

Amyotrophic lateral sclerosis (ALS) is a degenerative disease. The neurons responsible for movement begin to die and muscle control is progressively lost, leading to a fatal outcome.

22 Mar 2024

Unraveling the complex cellular composition of aldosterone-producing adenomas

Researchers from Tokyo Medical and Dental University (TMDU) find that the cells that make up aldosterone-producing adenomas become more transcriptionally active and express higher levels of genes linked to hormone production over intratumoral differentiation.

1 Mar 2024

Breakthrough gene therapy method utilizes bird retrotransposon for safe gene insertion

The recent approval of a CRISPR-Cas9 therapy for sickle cell disease demonstrates that gene editing tools can do a superb job knocking out genes to cure hereditary disease.

20 Feb 2024