Small Intestine News and Research

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Longitudinal study reveals how GLP-2 analog therapy transforms the intestinal environment

Researchers from Japan discover that glucagon-like peptide-2 (GLP-2) analogs can deeply and beneficially reshape the intestinal environment.

27 Aug 2025

Targeting gut signaling protein may protect against alcohol-related liver damage

Alcohol-associated liver disease (ALD) is a major cause of liver transplantation and death worldwide, and its impact is only growing. In 2022, the annual cost of ALD in the United States was $31 billion.

27 Aug 2025

Genetic variants influencing vitamin D synthesis, metabolism, and transport

A Canadian review synthesizes genetic factors that influence vitamin D synthesis, metabolism, and transport, highlighting how polymorphisms affect circulating levels. It also explores how gene-environment interactions shape individual responses to supplementation and sunlight.

20 Aug 2025

NYU Langone Hospital—Suffolk performs first robotic cancer surgeries

Continuing its transformation since joining NYU Langone Health, the operative team at NYU Langone Hospital—Suffolk recently performed four complex robotic surgeries that had never been offered at the facility before, three of which successfully removed cancerous tumors from patients.

13 Aug 2025

New clues to how food allergies trigger anaphylaxis

New research in mice reveals that food-induced anaphylaxis is driven by distinct immune pathways involving inflammatory lipids called leukotrienes.

7 Aug 2025

Fecal transplant may cut infections in long-term care patients

Fecal microbiota transplantation in long-term care patients shows safety and potential to lower infection rates, despite persistent drug-resistant colonization.

5 Aug 2025

Gut hormone INSL5 linked to chronic diarrhea in patients with bile acid malabsorption

High levels of a hormone found in cells in the gut could underlie many cases of chronic diarrhea and help explain up to 40% of cases of patients with irritable bowel syndrome with diarrhea, according to a new study led by scientists at the University of Cambridge.

29 Jul 2025

New swallowable sensor pill reveals gut inflammation with a simple color change

Researchers have developed an ingestible biosensor pill (PRIM) that detects intestinal inflammation by releasing a blue dye in response to elevated reactive oxygen species, providing a simple, at-home visual indicator.

27 Jul 2025

Gut bacteria send direct signals to the brain to stop you from overeating

Researchers have discovered a novel gut-brain sensory circuit in mice where specialized colonic cells sense bacterial flagellin and rapidly suppress feeding via the vagus nerve. This "neurobiotic sense" operates independently of immune pathways, revealing a direct neural mechanism for microbiota-host communication.

24 Jul 2025

New insights reveal how the immune system fights intestinal parasites

New research from the University of Pittsburgh reveals how the immune system defends against intestinal parasitic worms, or helminths, one of the most common infections worldwide in communities with limited access to clean water and sanitation.

22 Jul 2025

Study uncovers a specialized gut-brain pathway for glucose sensing

In a groundbreaking study, a research team at KAIST has uncovered a gut-brain circuit that enables the brain to selectively recognize glucose—beyond simply registering total caloric intake.

21 Jul 2025

Why buckwheat may be the best flour for gluten-free baking

Research shows buckwheat flour leads in gluten-free scone acceptability, emphasizing its role in enhancing texture and taste in gluten-free bakery products.

16 Jul 2025

Organ chip technology accurately predicts chemotherapy response in esophageal adenocarcinoma patients

Esophageal adenocarcinoma (EAC), one of two major forms of esophageal cancer, is the sixth most deadly cancer worldwide for which no effective targeted therapy exists.

27 Jun 2025

Low FODMAP diet shown to improve gastrointestinal symptoms in women with endometriosis

A low FODMAP diet developed by Monash University researchers for irritable bowel syndrome (IBS) has been shown to improve gastrointestinal symptoms in women with endometriosis.

23 Jun 2025

Estrogen-responsive cells found to heighten gut pain in females

Researchers uncovered how estrogen heightens gut sensitivity in females by activating PYY-secreting L-cells, which stimulate serotonin release from EC cells. This paracrine circuit intensifies pain signaling and may explain the sex bias in conditions like IBS.

16 Jun 2025

Nanoplastics reshape gut microbiome, weakening gut defenses

Polystyrene nanoplastics impact gut health by modifying microbiota interactions via extracellular vesicles, raising concerns about environmental nanoplastics.

12 Jun 2025

Study reveals 15 hidden genetic risk factors for celiac disease

This comprehensive GWAS reveals 15 new genetic variants linked to celiac disease, offering insights for earlier detection and tailored treatment strategies.

9 Jun 2025

New study warns of long-term risks from fecal microbiota transplants

Fecal microbiota transplants (FMT) have been touted as a potential treatment for a variety of conditions, from inflammatory bowel diseases, obesity, and type 2 diabetes to autism.

6 Jun 2025

Understanding cow’s milk allergy in breastfed infants

Cow’s milk allergy (CMA) affects up to 2.2% of infants, with a complex interplay of immunological mechanisms, allergen transfer via breast milk, and variable responses to maternal elimination diets. Current evidence challenges the routine use of maternal dietary restrictions, highlighting the need for precise diagnosis and further research.

27 May 2025

$Discovery of mutated immune cell clones could point to improved treatment for refractory celiac disease$

Discovery of mutated immune cell clones could point to improved treatment for refractory celiac disease

Scientists have identified mutated immune cell clones that could point to improved treatment for refractory celiac disease.

15 May 2025