Therapeutics News and Research

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Long non-coding RNAs offer new pathways to overcome cancer treatment resistance

Scientists are highlighting long non-coding RNAs (lncRNAs) as promising targets in the effort to overcome one of cancer treatment's most persistent challenges: therapeutic resistance.

12 Oct 2026

RNA modification enzyme FTO shows therapeutic promise in gastrointestinal cancers

A new review in Genes & Diseases highlights FTO, an enzyme involved in RNA modification, as a potentially important biomarker and therapeutic target across gastrointestinal cancers.

12 Oct 2026

Review highlights EP4 receptor as target for inflammatory diseases

A review published in Genes & Diseases highlights the prostaglandin E2 receptor subtype 4 (EP4) as an important regulator of inflammation and a promising therapeutic target for a wide range of inflammatory and inflammation-related diseases.

12 Oct 2026

Targeting mitochondrial vulnerabilities could help treat triple-negative breast cancer

A deeper understanding of mitochondrial function could create new opportunities for treating triple-negative breast cancer (TNBC), one of the most aggressive and difficult-to-treat forms of breast cancer.

12 Oct 2026

Targeting lipophagy could help treat metabolic and oxidative stress-related diseases

A review published in Genes & Diseases highlights lipophagy, the cellular process that selectively breaks down lipid droplets, as a potentially important therapeutic target for conditions driven by disrupted lipid metabolism and oxidative stress.

12 Oct 2026

New review highlights expanding potential of therapeutic DNA vaccines

A new review published in Genes & Diseases highlights the expanding potential of DNA-based vaccines as a flexible platform for preventing infectious diseases, treating cancer and strengthening preparedness for future disease outbreaks.

12 Oct 2026

Buck Institute and Georgetown lead effort mapping harmful protein changes before disease begins

A research "super team" co-led by theBuck Institute for Research on Aging and Georgetown University has received an award of up to $51.7 million from the Advanced Research Projects Agency for Health (ARPA-H) to predict how disease-causing proteins misfold before irreversible damage occurs and use those predictions to develop novel diagnostics and treatments.

12 Oct 2026

Oregon's licensed psilocybin centers prioritize safety but remain highly expensive

A new study has found that Oregon's licensed psilocybin centers largely follow recommended safety guidelines, offering reassurance about how the first regulated psilocybin programs in the U.S. function in practice - though the cost of treatment may keep it out of reach for many.

12 Oct 2026

Amphista Therapeutics announces first patient dosed in AMX-883 Phase 1 clinical trial for acute myeloid leukemia

Amphista Therapeutics Limited ('Amphista'), a leader in the discovery and development of non-cereblon / VHL targeted protein degradation (TPD) medicines, today announced dosing of the first patient in a Phase 1 trial for its lead candidate, AMX-883. Initiated following authorization from the U.S. Food and Drug Administration in June 2026, the BRAMLIE trial will investigate the safety, pharmacokinetics, and preliminary efficacy of AMX-883 monotherapy in participants with AML and high-risk MDS.

From Amphista Therapeutics 12 Oct 2026

New project aims to test a protein-based therapy for Fragile X syndrome

A new research project at the University of California, Riverside, has received funding to investigate whether a novel protein-based therapy can correct abnormal brain activity associated with Fragile X syndrome.

9 Oct 2026

Study finds both the liver and brain drive distinct symptoms of rare genetic epilepsy

A recent study from Johns Hopkins Medicine reveals that both the liver and brain contribute pathways to differing symptoms of the same rare inherited disorder.

9 Oct 2026

New project aims to predict early protein dysfunction in neurodegenerative diseases

Neurodegenerative diseases such as Alzheimer's, Parkinson's, ALS and Huntington's are associated with proteins that can change shape, stick together and eventually damage cells.

9 Oct 2026

Sutter Health care model safely expands local Alzheimer's treatment

A multidisciplinary care model developed across Sutter Health helped general neurologists address a practical challenge facing health systems nationwide: how to safely offer newer Alzheimer's disease treatments in community settings to more patients.

9 Oct 2026

Real time molecular movie unlocks secrets of penicillin biosynthesis

Researchers from the University of Oxford and international collaborators have revealed previously unseen rapid chemical stages in the formation of β-lactam antibiotics like penicillin, offering insights that can support future antibiotic development.

9 Oct 2026

Rare dendritic cells may promote immune tolerance in metastatic cancer

This study was co-led by Steven Blum, MD. Gary Reynolds, MD, PhD, Samuel Klempner, MD, and Alexandra-Chloé Villani, PhD, jointly supervised the work at the Krantz Family Center for Cancer Research within the Mass General Brigham Cancer Institute and the Mass General Brigham Center for Immunology & Inflammatory Diseases (CIID).

8 Oct 2026

Brief safety reminders help reduce harmful clinical AI decisions

As artificial intelligence (AI) becomes increasingly capable of assisting with health care tasks, a new study by researchers at the Icahn School of Medicine at Mount Sinai has found that adding a brief safety reminder reduced potentially harmful choices by AI models in clinical scenarios.

8 Oct 2026

Universal germline genetic testing catches missed cancer risks in older patients

Universal germline genetic testing of nearly 40,000 patients with solid tumors detected a substantial proportion of inherited gene variants that would have been missed by the standard germline testing approach that excludes those over age 50.

8 Oct 2026

ELRIG and The Protein Society announce keynote speakers for Protein Sciences in Drug Discovery 2026

ELRIG, a not-for-profit, volunteer-led organization dedicated to the global drug discovery community, and The Protein Society, an international, not-for-profit, scholarly society, with the mission to provide forums for the advancement of research into protein structure, function, design and applications, today announced the keynote speakers for Protein Sciences in Drug Discovery 2026.

From ELRIG (UK) Ltd. 8 Oct 2026

USC researchers receive $4 million to test psychedelic therapy and mindfulness for depression

A team of USC researchers has received an up to $4 million award from the Advanced Research Projects Agency for Health (ARPA-H) to conduct a clinical trial of psychedelic therapy and mindfulness training for depression.

6 Oct 2026

Novel peptide approach reduces chronic neuropathic pain in mice

Understanding and treating chronic neuropathic pain has remained challenging due to its complex nature. New research from the lab of Clifford Woolf, MB, BCh, PhD, at Boston Children's Hospital's FM Kirby Neurobiology Center describes a novel approach for reducing pain by disrupting interactions within pain-sensing nerve cells called nociceptors

6 Oct 2026

Therapeutics News and Research

Long non-coding RNAs offer new pathways to overcome cancer treatment resistance

RNA modification enzyme FTO shows therapeutic promise in gastrointestinal cancers

Review highlights EP4 receptor as target for inflammatory diseases

Targeting mitochondrial vulnerabilities could help treat triple-negative breast cancer

Targeting lipophagy could help treat metabolic and oxidative stress-related diseases

New review highlights expanding potential of therapeutic DNA vaccines

Buck Institute and Georgetown lead effort mapping harmful protein changes before disease begins

Oregon's licensed psilocybin centers prioritize safety but remain highly expensive

Amphista Therapeutics announces first patient dosed in AMX-883 Phase 1 clinical trial for acute myeloid leukemia

New project aims to test a protein-based therapy for Fragile X syndrome

Study finds both the liver and brain drive distinct symptoms of rare genetic epilepsy

New project aims to predict early protein dysfunction in neurodegenerative diseases

Sutter Health care model safely expands local Alzheimer's treatment

Real time molecular movie unlocks secrets of penicillin biosynthesis

Rare dendritic cells may promote immune tolerance in metastatic cancer

Brief safety reminders help reduce harmful clinical AI decisions

Universal germline genetic testing catches missed cancer risks in older patients

ELRIG and The Protein Society announce keynote speakers for Protein Sciences in Drug Discovery 2026

USC researchers receive $4 million to test psychedelic therapy and mindfulness for depression

Novel peptide approach reduces chronic neuropathic pain in mice

Next-generation therapeutics eBook eBook

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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