VEGF News and Research

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VEGF is a substance made by cells that stimulates new blood vessel formation. Also called vascular endothelial growth factor.

Targeting ADAM10 may offer hope for retinal disease treatment

New research has found that the endothelial cell-specific A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) regulates abnormal blood vessel growth in the damaged retina, which can cause vision loss or impairment.

25 Jun 2025

Navigating the dual role of B cells in tumor immunity

B lymphocytes exhibit dual roles in tumorigenesis, acting as both allies and adversaries in the tumor microenvironment (TME).

3 Jun 2025

Nuclera and Cytiva collaborate to accelerate characterization of proteins for drug development

Nuclera, the biotechnology company accelerating protein expression and optimization through its benchtop eProtein Discovery™ System, has announced a collaboration with Cytiva, a global life sciences leader.

28 May 2025

Exploring the complex association between anemia and retinopathy of prematurity

Anemia is a common condition in premature infants, particularly those at risk for retinopathy of prematurity (ROP).

10 Apr 2025

The evolution of OCT for retinal imaging and disease intervention

Dr. Yifan Jian explores the evolution of OCT, challenges in retinal imaging, and AI's potential in biophotonics, shaping the future of ophthalmic diagnostics.

From Avantier Inc. 1 Apr 2025

Artificial ligaments could revolutionize ACL surgery and recovery

Anterior cruciate ligament (ACL) injuries are common, especially among athletes. Each year, over 400 000 ACL reconstruction (ACLR) surgeries are carried out globally.

27 Feb 2025

Novel therapeutic approaches targeting the Wnt pathway in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the deadliest cancers globally, with increasing incidence and mortality rates.

19 Feb 2025

Study uncovers distinct blood protein signature in children with Long COVID

Distinct protein profiles linked to inflammation and angiogenesis found in children with Long COVID, paving the way for improved diagnostics and therapies.

28 Jan 2025

Genetic discoveries drive new approaches to treating cerebral vascular malformations

Cerebral vascular malformations (CVMs), including cerebral arteriovenous malformations (AVMs) and cavernous malformations (CCMs), have long posed challenges due to their complex origins and severe clinical implications.

13 Jan 2025

Brown adipose tissue could enhance exercise performance and longevity

A new research perspective was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 22 on December 18, 2024, entitled "Brown adipose tissue enhances exercise performance and healthful longevity."

8 Jan 2025

Potential new mRNA-based therapy for pre-eclampsia

Lipid nanoparticles targeting VEGF mRNA show promise in treating pre-eclampsia, restoring maternal blood pressure and enhancing fetal health in murine models.

13 Dec 2024

Groundbreaking research offers hope for pregnant people with pre-eclampsia

Penn Engineers have made a critical breakthrough that bridges a major healthy equity gap for pregnant people with pre-eclampsia, a condition that arises due to insufficient blood flow to the placenta and results in high maternal blood pressure and restricted blood flow to the fetus.

11 Dec 2024

TCR sequencing sheds light on tumor immune interactions in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) stands as the dominant form of liver cancer, ranking as the fourth leading cause of cancer-related deaths globally.

11 Dec 2024

Asimov and RevOpsis Therapeutics sign licensing agreement for high titer multispecific-expressing cell line

Asimov, the synthetic biology company advancing the design and manufacture of therapeutics, today announced a licensing agreement for its CHO Edge System with RevOpsis Therapeutics ("RevOpsis"), a next-generation biopharmaceutical company spearheading innovation of multispecific biologics in ophthalmic therapies

From Asimov 25 Nov 2024

Engineered SNIPRs transform CAR T-cell precision for safer cancer therapy

Researchers developed SNIPRs, innovative receptors that sense soluble ligands, enabling precise therapeutic control in CAR T-cells. This breakthrough enhances tumor targeting while reducing off-target effects, paving the way for advanced synthetic biology applications.

17 Nov 2024

Customizable biological sensors activate cancer immunotherapy only in tumor environments

Most cancer treatments – from chemotherapies to engineered immune cells – have a host of side effects, in large part because they affect healthy cells in the body at the same time as targeting tumor cells.

15 Nov 2024

Key kinase involved in cell division linked to abnormal blood vessel growth in genetic disorder

Inhibition of CDK6 may prevent arteriovenous malformations in hereditary hemorrhagic telangiectasia by regulating endothelial cell cycle progression.

8 Nov 2024

Johns Hopkins study offers new hope for wet AMD patients

A new study from researchers at Wilmer Eye Institute, Johns Hopkins Medicine explains not only why some patients with wet age-related macular degeneration (or "wet" AMD) fail to have vision improvement with treatment, but also how an experimental drug could be used with existing wet AMD treatments to save vision.

4 Nov 2024

CKMT2 regulates mitochondrial function and energy metabolism in type 2 diabetes

Creatine kinase M2 (CKMT2) plays a key role in mitochondrial dysfunction in type 2 diabetes, affecting energy metabolism in skeletal muscle.

10 Oct 2024

The role of geroscience in understanding Alzheimer’s Disease

For more than 30 years, researchers have identified and quantified genetic and lifestyle factors for Alzheimer's Disease (AD) and other dementias. Despite extensive research, the fundamental mechanisms behind these neurodegenerative diseases are still not fully understood, and effective management of AD is taking longer than expected.

10 Oct 2024