in vivo News and Research

RSS

New review shows why antidepressants often fail in Alzheimer’s and Parkinson’s depression

A Molecular Psychiatry review shows that depression in Alzheimer’s and Parkinson’s disease may reflect disease-specific molecular, neurotransmitter, inflammatory, and circuit-level disruptions rather than standard depression biology alone. It argues that broad antidepressants often show limited efficacy in these patients and that future trials should use biomarkers, neuroimaging, and symptom profiling to guide targeted treatments.

7 Jul 2026

Innovative polysaccharide hydrogels offer new hope for healing wounds

Announcing a new article publication in BIO Integration. Skin wound healing, especially in chronic non-healing conditions, such as diabetic foot ulcers and infected wounds, remains a formidable clinical challenge due to the complex pathophysiologic mechanisms and prolonged repair processes.

7 Jul 2026

Could IVF affect heart health after pregnancy?

Women with IVF-conceived pregnancies exhibit higher large artery stiffness, indicating potential cardiovascular risks that warrant further investigation.

7 Jul 2026

Study provides new insights into biological processes linked to Huntington’s disease

A study conducted by the Sant Pau Research Institute (IR Sant Pau) and Hospital de Sant Pau has identified for the first time in living individuals a brain pattern related to the tau protein that changes according to the stage of Huntington's disease.

6 Jul 2026

Feeder-free TIL expansion system makes advanced cancer immunotherapy safer

Conventional TIL therapy, clinically validatedrecently with the U.S. Food and Drug Administration approval of lifileucel for advanced melanoma,stillfaces substantial hurdles.

3 Jul 2026

Study potential new therapeutic strategy for patients with ATRX-mutant gliomas

A new study from researchers at The University of Texas MD Anderson Cancer Center has uncovered how one of the most common genetic alterations in glioma rewires the cancer cell genome to fuel tumor progression, suggesting a potential new therapeutic strategy for patients with ATRX-mutant gliomas.

1 Jul 2026

Smart prodrug targets Alzheimer's disease using hydrogen peroxide signals

A substance that worsens dementia has become a "switch" that initiates treatment. KAIST researchers have developed a new therapeutic approach that uses hydrogen peroxide (H₂O₂), a reactive oxygen species that damages cells and increases in the brains of patients with Alzheimer's disease, to activate a drug selectively in diseased brain tissue.

1 Jul 2026

New bacterial enzyme blueprint could accelerate cancer treatment development

A team of researchers at the University of Warwick and Monash University has solved a puzzle that's stumped drug developers for decades: how bacteria naturally create multiple versions of powerful cancer therapies.

1 Jul 2026

Researchers develop new model to study aggressive melanomas

Researchers have created a powerful new cellular model to study rare tumors that are resistant to immunotherapies.

29 Jun 2026

Lithium MRI scans offer personalized treatments for bipolar disorder

A revolutionary scanning technique has revealed that lithium MRI is a powerful tool for studying how the drug interacts with the brain and could offer more personalized treatment for bipolar disorder.

29 Jun 2026

Single DNA injection provides long-lasting weight loss in mouse study

Scientists at The Wistar Institute have shown that a single injection of a small, circular piece of genetic instructions can produce weight loss and blood glucose control in murine models that lasts up to 10 times as long as incretin-mimicking drugs like Ozempic and Wegovy.

26 Jun 2026

Study identifies fPRDM16 as target for age-related pulmonary fibrosis

A study published recently in Current Molecular Pharmacology has uncovered a key mechanism linking aging to persistent pulmonary fibrosis, identifying the transcriptional regulator fPRDM16 as a potential therapeutic target.

25 Jun 2026

Study identifies key fibrotic cells driving hypertrophic scars

Hypertrophic scars (HS) are abnormal outcomes of wound healing, marked by excessive extracellular matrix (ECM) deposition and impaired scar remodeling.

25 Jun 2026

New eye imaging technology captures clearer details of retina

Modern OCT devices can look inside the eye without a scalpel - but they do not always capture everything that matters. Some critical information is simply lost, blurred by scattered photons.

24 Jun 2026

Psychological traits may uncover why Alzheimer’s biology differs between patients

In 822 deceased older adults from ROS and MAP, researchers linked stable psychological traits to multi-omic molecular subtypes of Alzheimer’s dementia using postmortem brain tissue from the dorsolateral prefrontal cortex. Neuroticism and loneliness were associated with molecular progression, while purpose in life showed subtype-specific inverse associations, suggesting psychological traits may align with Alzheimer’s biology beyond conventional neuropathology.

22 Jun 2026

Optimized proximity labeling platform tracks cellular protein communication networks

The body's organs are in constant communication. Fat tissue tells the liver when to store or release energy, the immune system signals localized inflammation, and thousands of proteins carry these messages to organs throughout the body.

22 Jun 2026

Engineered CAR-T cells offer potential rheumatoid arthritis cure

For the 18 million people living with rheumatoid arthritis, disease management currently means a lifetime of injections-a reality that new research from Tsinghua University may soon begin to change.

22 Jun 2026

Gene therapy successfully treats deadly childhood liver disease in mice

A new gene therapy has been used to successfully treat a deadly childhood liver disease using mice that model this disease by researchers at UCL and Great Ormond Street Hospital.

19 Jun 2026

Deep learning identifies novel compounds against antibiotic-resistant gonorrhea

With tens of millions of annual cases, gonorrhea is the second most frequently reported sexually transmitted infection (STI). Alone in the U.S., over 600,000 cases are reported each year.

17 Jun 2026

AI-designed drug for Parkinson's begins first human trial

Insilico Medicine ("Insilico", HKEX: 3696), a clinical-stage biotechnology company powered by generative artificial intelligence (AI), today announced it has achieved the first clinical milestone in its co-development collaboration with Hygtia Therapeutics with the completion of first-in-human dosing in the Phase I study of ISM8969.

17 Jun 2026