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Virtual screening yields small molecules to enhance cancer immunotherapy

The process of identifying promising small molecule drug candidates that target cancer checkpoints may become faster and smarter through virtual screening, according to Weill Cornell Medicine researchers.

7 Nov 2024

Study links high blood sugar to thrombosis risk in diabetes

A study conducted at the Center for Research on Redox Processes in Biomedicine (Redoxoma) helps understand how high blood sugar (hyperglycemia), one of the manifestations of diabetes, can cause thrombosis.

6 Nov 2024

Nanoscale sensor detects lung cancer through breath chemistry

Exhaled breath contains chemical clues to what's going on inside the body, including diseases like lung cancer.

6 Nov 2024

New research uncovers 16 genes that aid breast cancer survival

Scientists at the Johns Hopkins Kimmel Cancer Center have identified 16 genes that breast cancer cells use to survive in the bloodstream after they've escaped the low-oxygen regions of a tumor.

5 Nov 2024

Curcumin compound reactivates Epstein–Barr virus, offering safer cancer therapy

A novel curcumin derivative, C210, activates the Epstein–Barr virus (EBV) lytic cycle without producing infectious virions by disrupting HSP90. This discovery opens avenues for safer EBV-positive cancer therapies.

5 Nov 2024

New technology for visualizing AMPA receptors offers insights into psychiatric disorders

Even though psychiatric disorders such as schizophrenia, bipolar disorder, and autism spectrum disorder (ASD) are quite common, their diagnosis and treatment are challenging.

5 Nov 2024

Celastrol's druggability, molecular targets, and nanocarrier delivery against chronic diseases

Announcing a new publication for Acta Materia Medica journal. Celastrol is an active compound from the root of Tripterygium wilfordii Hook F that shows great potential in the treatment of inflammation, cancer, neurodegeneration, diabetes, and obesity.

5 Nov 2024

Scientists discover how the keto diet may help some people with multiple sclerosis

Scientists have long suspected the keto diet might be able to calm an overactive immune system and help some people with diseases like multiple sclerosis.

4 Nov 2024

Menthol cigarette restrictions could lead to healthier choices

Nationwide, fewer people smoke than did a decade ago, but the proportion who smoke menthol-flavored cigarettes is on the rise.

4 Nov 2024

New study identifies potential treatment for tauopathies using carbonic anhydrase inhibitors

Carbonic anhydrase inhibitors show potential in reducing tau protein buildup, offering new therapeutic avenues for neurodegenerative diseases like tauopathies.

4 Nov 2024

Carbonic anhydrase inhibitors clear tau build-up in zebrafish models of tauopathies

A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein tau, which causes various forms of dementia and is implicated in Alzheimer’s disease.

4 Nov 2024

Research uncovers new mechanism in protein aggregation linked to Parkinson's disease

A team of researchers at Kumamoto University has uncovered a groundbreaking mechanism in the formation of harmful protein aggregates that lead to neurodegenerative diseases such as Parkinson's Disease.

1 Nov 2024

Glaucoma medication may help prevent Alzheimer's-related tau build-up

1 Nov 2024

Researchers develop novel oxygen-independent therapy for cancer

Tumors often contain areas of oxygen-deficient tissue that frequently withstand conventional therapies. This is because the drugs applied in tumors require oxygen to be effective. An international research team has developed a novel mechanism of action that works without oxygen: polymeric incorporated nanocatalysts target the tumor tissue selectively and switch off the glutathione that the cells need to survive.

1 Nov 2024

Curcumin shows promise in preventing and treating oral submucosal fibrosis

Researchers explore the mechanisms, therapeutic potential, and clinical applications of curcumin in preventing and treating oral submucosal fibrosis.

30 Oct 2024

Scientists discover novel compound to combat age-related blindness

Rensselaer Polytechnic Institute's Christopher Cioffi, Ph.D., Thomas and Constance D'Ambra Professor in Organic Chemistry, has been collaborating with Konstantin Petrukhin, Ph.D., Professor of Ophthalmic Science at Colombia University, to develop compounds to treat dry age-related macular degeneration (AMD) and Stargardt disease - both blindness-causing diseases.

28 Oct 2024