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Hormone levels tied to metabolic health in obesity

Researchers investigate the relationship between obesity types and serum leptin (LEP) and adiponectin (ADP) levels, shedding light on metabolic differences in various obesity phenotypes. Their findings highlight correlations between adipokines, glucose utilization, lipid metabolism, and obesity-related metabolic disorders.

22 Oct 2023

How chromatin compartmentalization affects DNA damage response

Researchers uncover novel insights into how chromatin compartmentalization influences the DNA damage response (DDR) after double-stranded breaks (DSBs), shedding light on the mechanisms behind genomic integrity maintenance and the risk of translocations. Their findings reveal the importance of chromosomal design in DNA repair and the potential implications for genome stability and cancer translocations.

22 Oct 2023

MIT engineers design workout mat for cells to study exercise's mechanical effects

There's no doubt that exercise does a body good, including strengthening and toning our muscles. But how exactly does exercise make this happen?

20 Oct 2023

Scientists uncover a group of immune cells that may drive severe asthma in older men

Scientists from La Jolla Institute for Immunology (LJI) and The University of Southampton, UK, have uncovered a group of immune cells that may drive severe asthma.

20 Oct 2023

Scientists develop gene therapy approach for rare paralyzing disease

The 50 families stretch from the Netherlands and the United Kingdom to the United States and China. Each family has a child who is paralyzed from a mutation in a single gene named Contactin-Associated Protein 1 (Cntnap1).

20 Oct 2023

New method uses magnets to align muscle cells

Stimulating muscle fibers with magnets causes them to grow in the same direction, aligning muscle cells within tissue, Massachusetts Institute of Technology (MIT) and Boston University investigators report October 20 in the journal Device.

20 Oct 2023

Study reveals how tuberculosis bacteria form cords to resist antibiotics

The ability of Mycobacterium tuberculosis (MTB), a serious respiratory infection, to form snake-like cords was first noted nearly 80 years ago. In a study published October 20 in the journal Cell, investigators report the biophysical mechanisms by which these cords form and demonstrate how several generations of dividing bacteria hang together to create these structures that enable resistance to antibiotics.

20 Oct 2023

Canine transmission models provide insights into the neurological impacts of COVID-19 on human brains

The histopathologic alteration caused by SARS‑CoV‑2 on mammalian neurological systems.

20 Oct 2023

The beneficial effects of regular physical activity on the cardiovascular profile in the elderly

The effect of regular physical activity (PA) on the microcirculatory functions and plasma antioxidant capacity in older athletes.

20 Oct 2023

Low serotonin levels observed in long COVID and other viral infections

Researchers identify a pathophysiological mechanism linking serotonin reduction to the multifaceted etiology of post-acute sequelae of COVID-19.

20 Oct 2023

Ferroptosis regulation of GLS2 as a potential therapeutic strategy against liver diseases

A new editorial paper was published in Oncotarget's Volume 14 on October 19, 2023, entitled, "GLS2 shapes ferroptosis in hepatocellular carcinoma."

19 Oct 2023

New method uses extracellular vesicles to enhance immunotherapy responses in glioblastoma

A team of researchers at The University of Texas MD Anderson Cancer Center has developed a new method for using extracellular vesicles to enhance responses to immunotherapy in glioblastoma, potentially opening the door for wider use of engineered messenger RNA (mRNA) for cancer therapy.

19 Oct 2023

Stanford Medicine researchers find new way to measure ocular aging

Using a technique they developed for studying eye fluid, Stanford Medicine researchers and their collaborators have found a way to measure ocular aging, opening avenues for treatment of numerous eye diseases.

19 Oct 2023

Collaborative team receives NCI grant to study how to improve immunotherapy for diffuse midline gliomas

Each year, approximately 200 to 300 children in the United States are diagnosed with diffuse midline gliomas (DMG), a tumor that begins in the brain or spinal cord.

19 Oct 2023

Oral pathogen linked to increased risk of heart rupture after heart attack

Researchers from Tokyo Medical and Dental University(TMDU) find that a periodontal pathogen, Porphyromonas gingivalis, inhibits autophagosome–lysosome fusion, and can therefore worsen cardiac remodeling and cause cardiac rupture after myocardial infarction.

19 Oct 2023

Lactate-producing intratumoral bacteria drive resistance to radiation therapy

Researchers at The University of Texas MD Anderson Cancer Center have discovered that lactate-producing intratumoral bacteria drives resistance to radiation therapy, suggesting that lactic acid-producing bacteria present in various cancers may serve as novel therapeutic targets.

19 Oct 2023

CAR T-cell therapy for multiple myeloma shows no difference in survival outcomes by race and ethnicity

Patients with multiple myeloma treated with idecabtagene vicleucel, known as "ide-cel," a chimeric antigen receptor (CAR) T-cell therapy, had no difference in overall survival outcomes regardless of race and ethnicity, according to a study published in Blood Advances.

19 Oct 2023

B Cell News and Research

Hormone levels tied to metabolic health in obesity

How chromatin compartmentalization affects DNA damage response

MIT engineers design workout mat for cells to study exercise's mechanical effects

Scientists uncover a group of immune cells that may drive severe asthma in older men

Scientists develop gene therapy approach for rare paralyzing disease

New method uses magnets to align muscle cells

Study reveals how tuberculosis bacteria form cords to resist antibiotics

Canine transmission models provide insights into the neurological impacts of COVID-19 on human brains

The beneficial effects of regular physical activity on the cardiovascular profile in the elderly

Low serotonin levels observed in long COVID and other viral infections

Ferroptosis regulation of GLS2 as a potential therapeutic strategy against liver diseases

New method uses extracellular vesicles to enhance immunotherapy responses in glioblastoma

Stanford Medicine researchers find new way to measure ocular aging

Collaborative team receives NCI grant to study how to improve immunotherapy for diffuse midline gliomas

Oral pathogen linked to increased risk of heart rupture after heart attack

Lactate-producing intratumoral bacteria drive resistance to radiation therapy

CAR T-cell therapy for multiple myeloma shows no difference in survival outcomes by race and ethnicity

Researchers profile new drug combinations to fight antibiotic-resistant bacteria

Common challenges when seeking market access for rare disease therapies

Can selenium and vitamin E supplementation prevent recurrence and progression of non–muscle-invasive bladder cancer?

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

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Advancing Intracellular Delivery with LumiPore®

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