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Scientists identify a class of drugs that may prevent alcohol use disorder in people with PTSD

Survivors of abuse and trauma are vastly more likely than other people to develop alcohol use disorder (AUD); according to some estimates, as many as three-quarters of people with post-traumatic stress disorder (PTSD) report drinking problems.

21 Nov 2022

Molecular motion of many 'undruggable' proteins reveals previously unseen binding sites

Studying the molecular motion of proteins reveals previously unseen binding sites that could be targeted by new drug candidate molecules.

21 Nov 2022

Anti-inflammatory pain relievers may worsen inflammation in osteoarthritis

Taking anti-inflammatory pain relievers like ibuprofen and naproxen for osteoarthritis may worsen inflammation in the knee joint over time, according to a new study being presented next week at the annual meeting of the Radiological Society of North America.

21 Nov 2022

Tackling Antimicrobial Resistance; A Conversation with the World Health Organisation

For World Antimicrobial Awareness Week (WAAW), we speak to Silvia Bertagnolio from the WHO, about the importance of raising awareness of antimicrobial resistance.

21 Nov 2022

Study provides a more accurate tool to stratify patients with HER2-positive breast cancer

Patients with a type of breast cancer called HER2-positive are less likely to survive if their initial treatment fails to eradicate the tumor completely and they have high levels of immune cells called tumor-infiltrating lymphocytes in the residual disease.

21 Nov 2022

FDA approves first-ever type 1 diabetes delaying drug Tzield (teplizumab-mzwv)

On November 17, 2022, the US Food and Drug Administration (FDA) approved a pathbreaking new drug called Tzield. This injectable formulation contains a combination of two drugs that could push back the onset of type 1 diabetes (T1D) in adults at stage 3 and children aged eight years or more at stage 2.

20 Nov 2022

Brain organoids reveal how alcohol exposure impairs the development and functioning of new brain cells

Alcohol consumption during pregnancy poses significant peril to the healthy development of the unborn child. There is no known safe amount of alcohol during pregnancy.

20 Nov 2022

Researchers uncover new therapeutic vulnerability in endocrine therapy-resistant breast cancers

For patients with estrogen receptor (ER)-positive breast cancer, development of the so-called Y537S mutation signals that their disease has taken an aggressive course and may become resistant to endocrine therapy.

20 Nov 2022

Study reveals mechanism by which malignant cells shut down anti-cancer immune responses

A Ludwig Cancer Research study has revealed a single protein expressed at high levels by cancer cells across a broad range of malignancies that erects a multifaceted barrier to anti-cancer immune responses in mouse models of cancer and so shields tumors from immune detection and destruction.

20 Nov 2022

New approach for delivering medication across the blood-brain barrier to treat brain tumors

Researchers have demonstrated in mice a new approach for delivering medication across the blood-brain barrier to treat tumors that cause aggressive, lethal brain cancer.

20 Nov 2022

β-cyclodextrin family found to be promising and cost-effective antiviral agents against SARS-CoV-2

Researchers identified β-cyclodextrins (β-CDs) as a safe and cost-effective drug against SARS-CoV-2 with a broad spectrum of activity.

18 Nov 2022

Pt(IV)-conjugated drug-delivery system shows efficacy in glioblastoma therapy

A recent study demonstrated a novel method for delivering anti-cancer drugs, conjugated to modified cell-penetrating peptides across the blood-brain barrier, in mice to treat glioblastoma.

18 Nov 2022

What is the prevalence of contraindications to Paxlovid among hospitalized COVID-19 patients?

Researchers examined the prevalence of contraindications to nirmatrelvir-ritonavir (Paxlovid) in hospitalized coronavirus disease 2019 (COVID-19) patients.

17 Nov 2022

New therapeutic windows for developing effective treatments for metastatic tumors

Cancer that splits and develops in new organs around the body becomes significantly more difficult to fight. Now, researchers at Chalmers University of Technology, Sweden, have shown that these metastatic cancers, that spread from the original, adapt their metabolism to the tissue in which they grow. The discovery represents a breakthrough for the understanding of metastatic cancer and is an important piece of the puzzle in the search for more effective treatments.

17 Nov 2022

National Institutes of Health funds a five-year, $11 million initiative

The conversations between our bone and muscle change as we age, and both are the weaker for it, Medical College of Georgia scientists say.

17 Nov 2022

Augmented drug preferentially eliminates cancer cells but does not harm healthy cells

Johns Hopkins Medicine researchers have revamped an anti-cancer drug to better target cancer cells and leave healthy tissues unharmed. Scientists have dubbed this type of targeted approach a "prodrug" - a medicine designed to release its payload in a particular area of the body and in no other areas.

17 Nov 2022

Among US veterans with COVID-19, few used antivirals or monoclonal antibodies

In a recent study published in the journal JAMA Network, researchers in the United States investigated factors that restricted the use of antivirals directed at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the United States (US) between January and February 2022.

16 Nov 2022

Key Alzheimer’s gene alters the way cholesterol moves around the brain, research finds

A gene recognized as the strongest risk factor for Alzheimer's disease (AD) alters the way cholesterol moves around the brain and as we age, this altered movement likely contributes to loss of learning and memory, a team of researchers from the Icahn School of Medicine at Mount Sinai and the Massachusetts Institute of Technology reports.

16 Nov 2022

ADHD drug associated with lowest risk of amphetamine-related hospitalizations and death

The ADHD medication lisdexamfetamine was associated with the lowest risk of hospitalization and death in people with amphetamine addiction, when medications generally used among persons with substance use disorders were compared.

16 Nov 2022

Amyloid-PET scanning has misled the FDA into granting approval for Aduhelm

Last year, the FDA gave accelerated approval of the antibody aducanumab (marketed as Aduhelm by Biogen) for the treatment of Alzheimer's disease.

16 Nov 2022

Drugs News and Research

Scientists identify a class of drugs that may prevent alcohol use disorder in people with PTSD

Molecular motion of many 'undruggable' proteins reveals previously unseen binding sites

Anti-inflammatory pain relievers may worsen inflammation in osteoarthritis

Tackling Antimicrobial Resistance; A Conversation with the World Health Organisation

Study provides a more accurate tool to stratify patients with HER2-positive breast cancer

FDA approves first-ever type 1 diabetes delaying drug Tzield (teplizumab-mzwv)

Brain organoids reveal how alcohol exposure impairs the development and functioning of new brain cells

Researchers uncover new therapeutic vulnerability in endocrine therapy-resistant breast cancers

Study reveals mechanism by which malignant cells shut down anti-cancer immune responses

New approach for delivering medication across the blood-brain barrier to treat brain tumors

β-cyclodextrin family found to be promising and cost-effective antiviral agents against SARS-CoV-2

Pt(IV)-conjugated drug-delivery system shows efficacy in glioblastoma therapy

What is the prevalence of contraindications to Paxlovid among hospitalized COVID-19 patients?

New therapeutic windows for developing effective treatments for metastatic tumors

National Institutes of Health funds a five-year, $11 million initiative

Augmented drug preferentially eliminates cancer cells but does not harm healthy cells

Among US veterans with COVID-19, few used antivirals or monoclonal antibodies

Key Alzheimer’s gene alters the way cholesterol moves around the brain, research finds

ADHD drug associated with lowest risk of amphetamine-related hospitalizations and death

Amyloid-PET scanning has misled the FDA into granting approval for Aduhelm

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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