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Administering specialized lipids prevents memory loss, inflammation in Down syndrome mouse model

Individuals with Down syndrome are at a much greater risk of developing Alzheimer's disease, with inflammation of the brain starting early in life and the risk of Alzheimer's reaching nearly 80% by the age of 60.

13 Mar 2020

Bacteria multiply and grow into biofilms like settlers form cities

Microbiologists have long adopted the language of human settlement to describe how bacteria live and grow: They "invade" and "colonize." Relations dwelling in close proximity are "colonies."

13 Mar 2020

Study provides insights on evaluating hypertension in children

Results from a new study provide insights on evaluating high blood pressure in children. The findings appear in an upcoming issue of CJASN.

13 Mar 2020

Testing shortages force extreme shift in strategy by local health officials

Public health officials in California's state capital region announced this week they have stopped tracing the contacts of patients diagnosed with the novel coronavirus. They've also ceased recommending quarantines for residents exposed to people confirmed to have the virus.

13 Mar 2020

Researchers engineer microparticles that show promise against transplant rejection

Inspired by a tactic cancer cells use to evade the immune system, University of Pittsburgh researchers have engineered tiny particles that can trick the body into accepting transplanted tissue as its own.

13 Mar 2020

Looking for answers after coronavirus contact? Welcome to the gray zone

Liz Lucas got a call Tuesday afternoon from a friend she'd interacted with closely at a journalism conference in New Orleans days earlier who had tested presumptively positive for coronavirus. She wondered what this meant for her and those around her, so she reached out to local and state health officials in Missouri for guidance.

13 Mar 2020

Experts call for older people to be considered in global responses to coronavirus

Current guidance on coronavirus “largely ignores” the implications for public health and clinical responses in light of those most at risk, according to an international group of global health experts.

13 Mar 2020

Overview of prognostic and predictive factors in pancreatic cancer

Oncotarget Volume 11, Issue 10 reported that there are not standardized predictive biomarkers able to identify patients who benefit most from treatments.

13 Mar 2020

Research reveals how skin cells embark on a swift yet elaborate death

Skin is our body's most ardent defender against pathogens and other external threats. Its outermost layer is maintained through a remarkable transformation in which skin cells swiftly convert into squames--flat, dead cells that provide a tight seal between the living portion of the skin and the world outside.

13 Mar 2020

Max Planck researchers identify mechanistic basis of antigen receptor gene assembly

Adaptive immunity is a powerful defense mechanism in vertebrates. A finely tuned interplay of different cell types provides a pathogen-specific immune response to eliminate for example bacteria and viruses.

13 Mar 2020

A miRNA signature linked to local-regional failure and overall survival after pancreatic cancer resection

The cover for issue 10 of Oncotarget features Figure 3, "Overall survival (OS) for high (red) versus low (black) risk groups in the (A) OSU, (B) TCGA, and (C) SNU resected cohorts," by Wolfe, et al.

13 Mar 2020

MicroRNA dysregulation has critical impacts on development, inflammation and cancer development

Oncotarget Volume 11, Issue 10 reported that dysregulation of noncoding micro RNA molecules has been associated with immune cell activation in the context of Helicobacter pylori-induced gastric inflammation as well as carcinogenesis, but also with downregulation of mismatch repair genes, and may interfere with immune checkpoint proteins that lead to the overexpression of antigens on gastric tumor cells.

13 Mar 2020

Characterization of DNAm status of MMPs and TIMPs in atheromatous plaques

Oncotarget Volume 11, Issue 10 reported that the statistically associated Cp G sites were analyzed in blood samples from two separate atherothrombotic stroke cohorts, ischemic stroke-cohort 1: 37 atherothrombotic patients and 6 controls, ischemic stroke-cohort 2: 80 atherothrombotic patients and 184 controls.

13 Mar 2020

Nanoscale particles of common plastics tend to move through the water supply

A Washington State University research team has found that nanoscale particles of the most commonly used plastics tend to move through the water supply, especially in fresh water, or settle out in wastewater treatment plants, where they end up as sludge, in landfills, and often as fertilizer.

13 Mar 2020

SPRK1 enzyme plays role in reorganizing the paternal genome during fertilization

A sperm enters an egg, an embryo develops and eventually a baby is born. But back up a second -- how does the mother's half-genome actually merge with the father's half-genome to form one new human genome?

13 Mar 2020

UC Riverside biochemist and Atomwise form new joint venture

Over the past few years, biochemist John Jefferson Perry at the University of California, Riverside, has collaborated on a number of projects with Atomwise Inc., a company that uses artificial intelligence, or AI, for drug discovery.

13 Mar 2020

Disease -related Wikipedia page view counts show impact of news media on public attention

During the 2016 Zika outbreak, news exposure appears to have had a far bigger impact than local disease risk on the number of times people visited Zika-related Wikipedia pages in the U.S. Michele Tizzoni and colleagues at the ISI Foundation in Turin, Italy, present these findings in PLOS Computational Biology.

13 Mar 2020

Tooth-enamel protein discovered in the eyes of people with dry AMD

A protein that normally deposits mineralized calcium in tooth enamel may also be responsible for calcium deposits in the back of the eye in people with dry age-related macular degeneration, according to a study from researchers at the National Eye Institute.

13 Mar 2020

Study estimates the asymptomatic transmission rate of novel coronavirus

Infectious disease researchers at The University of Texas at Austin studying the novel coronavirus were able to identify how quickly the virus can spread, a factor that may help public health officials in their efforts at containment.

13 Mar 2020

Researchers find strong behavioral signal to indicate autism risk in infants

In the first study of its kind, University of Miami researchers have found a strong behavioral signal to indicate which infants who have an older sibling with an autism spectrum disorder will themselves be diagnosed with ASD as they grow older.

13 Mar 2020

Research News and Research

Administering specialized lipids prevents memory loss, inflammation in Down syndrome mouse model

Bacteria multiply and grow into biofilms like settlers form cities

Study provides insights on evaluating hypertension in children

Testing shortages force extreme shift in strategy by local health officials

Researchers engineer microparticles that show promise against transplant rejection

Looking for answers after coronavirus contact? Welcome to the gray zone

Experts call for older people to be considered in global responses to coronavirus

Overview of prognostic and predictive factors in pancreatic cancer

Research reveals how skin cells embark on a swift yet elaborate death

Max Planck researchers identify mechanistic basis of antigen receptor gene assembly

A miRNA signature linked to local-regional failure and overall survival after pancreatic cancer resection

MicroRNA dysregulation has critical impacts on development, inflammation and cancer development

Characterization of DNAm status of MMPs and TIMPs in atheromatous plaques

Nanoscale particles of common plastics tend to move through the water supply

SPRK1 enzyme plays role in reorganizing the paternal genome during fertilization

UC Riverside biochemist and Atomwise form new joint venture

Disease -related Wikipedia page view counts show impact of news media on public attention

Tooth-enamel protein discovered in the eyes of people with dry AMD

Study estimates the asymptomatic transmission rate of novel coronavirus

Researchers find strong behavioral signal to indicate autism risk in infants

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