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Specific mutations in the monkeypox virus contribute to its continued infectiousness

Monkeypox has infected more than 77,000 people in more than 100 countries worldwide, and - similar to COVID-19 - mutations have enabled the virus to grow stronger and smarter, evading antiviral drugs and vaccines in its mission to infect more people.

4 Nov 2022

Green tea catechins and resveratrol display neuroprotective properties in Alzheimer's models

In a recent study published in the journal Free Radical Biology and Medicine, researchers screened for neuroprotective compounds against Alzheimer’s disease (AD).

3 Nov 2022

UQ spin-off company to develop precision painkillers for treating debilitating conditions

Precision painkillers that are more accurate and less harmful to the liver are set to be developed by a University of Queensland spin-off company - potentially changing the lives of millions of people.

3 Nov 2022

Scientists uncover a key property needed for CELMoD drugs to be effective

Scientists at Scripps Research have uncovered a critical feature that a promising new class of cancer drugs, known as CELMoDs, needs to be effective.

3 Nov 2022

Researchers provide insights on how to overcome resistance in cancer therapy

The latest developmental drugs, particularly for the use in oncology, rely on the targeted degradation of harmful pathogenic proteins.

3 Nov 2022

New test detects low levels of pathogenic amphiphilic endotoxins

Researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed a fast and cost-effective method to test liquids for a ubiquitous family of chemical compounds known as amphiphiles, which are used to detect diseases such as early-stage tuberculosis and cancer as well as to detect toxins in drugs, food, medical devices and water supplies.

3 Nov 2022

Researchers develop point-of-care device to facilitate monitoring of hereditary and hepatic metabolic disorders

Ammonium is a biomarker used to diagnose a series of rare hereditary metabolic disorders, such as the primary disorders of the urea cycle and different organic acidemias, as well as other metabolic and environmental conditions affecting the liver's function, which can cause a secondary dysfunction of the urea cycle.

3 Nov 2022

Investigating the role of the gut-to-brain axis in defensive responses

In a new study, researchers investigated the function of the gut-to-brain axis in defensive responses induced by toxins.

3 Nov 2022

Study determines the diagnostic utility of liver stiffness measurement

Even after chronic hepatitis C has been cured, portal hypertension remains the major factor driving the development of complications in advanced liver disease. In cooperation with researchers from Spain, a research team led by Georg Semmler and Mattias Mandorfer from the Division of Gastroenterology and Hepatology at MedUni Vienna's Department of Medicine III showed that the non-invasive tests explored in their earlier studies accurately estimate the probability of sequelae.

3 Nov 2022

New insights into the dynamic inner world of the human immune system

As researchers glean new insights into the dynamic inner world of the human immune system, it has become increasingly clear that mitochondria are critical regulators of how our bodies respond to disease.

3 Nov 2022

Many middle-aged adults unlikely to participate in dementia prevention clinical trials

Right now, drug companies and university-based teams are working urgently to find and test new medications that could prevent or slow the decline of brain function in older adults.

2 Nov 2022

RSV and kids: What you need to know

An overview on the prevalence, symptoms, and management of RSV in children.

2 Nov 2022

First-of-its-kind computer model simulates a clinical trial evaluating two Alzheimer’s drugs

An estimated 6.2 million Americans ages 65 and older are living with Alzheimer's disease. The national Alzheimer's Association predicts that number to grow to 13.8 million by 2060, barring the development of medical breakthroughs that would prevent, slow or cure the debilitating disease.

2 Nov 2022

Molecular drug transporters could improve treatment of cancers and other diseases

A team of Canadian researchers from Université de Montréal has designed and validated a new class of drug transporters made of DNA that are 20,000 times smaller than a human hair and that could improve how cancers and other diseases are treated.

2 Nov 2022

What is the role of cyclophilin-A in alleviating SARS-CoV-2 infections?

A new study aimed to analyze the molecular interactions between the hCypA protein and the SARS-CoV-2 variants to determine the impact of variants on the blocking and binding potential of the hCypA–S protein complex with the ACE2 receptor.

2 Nov 2022

How does imprinted SARS-CoV-2 humoral immunity drive convergent Omicron evolution?

Researchers examined how imprinted SARS-CoV-2 humoral immunity drives convergent evolution in continuously emerging Omicron subvariants.

2 Nov 2022

New research lays the foundation for more effectively treating pediatric brain tumor

In a ground-breaking new study, scientists have uncovered the mechanics of the blood-tumor barrier, one of the most significant obstacles to improving treatment efficacy and preventing the return of cancerous cells.

1 Nov 2022

New method helps gain fundamental insights into ribosome function

Inside tiny cellular machines called ribosomes, chains of genetic material called messenger RNAs (mRNAs) are matched with the corresponding transfer RNAs (tRNAs) to create sequences of amino acids that exit the ribosome as proteins.

1 Nov 2022

New review elucidates current treatment approaches for myelodysplastic syndromes

Physician scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have published a review in the Journal of the American Medical Association that clarifies current treatment approaches for myelodysplastic syndromes (MDS), which are rare and often deadly bone marrow cancers.

1 Nov 2022

First preclinical model to study the pathobiology of appendiceal cancer

Appendiceal cancer (malignancies of the appendix, a small tissue pouch that is part of the gastrointestinal tract) is very rare, occurring in perhaps one or two people per 1 million per year.

1 Nov 2022

Drugs News and Research

Specific mutations in the monkeypox virus contribute to its continued infectiousness

Green tea catechins and resveratrol display neuroprotective properties in Alzheimer's models

UQ spin-off company to develop precision painkillers for treating debilitating conditions

Scientists uncover a key property needed for CELMoD drugs to be effective

Researchers provide insights on how to overcome resistance in cancer therapy

New test detects low levels of pathogenic amphiphilic endotoxins

Researchers develop point-of-care device to facilitate monitoring of hereditary and hepatic metabolic disorders

Investigating the role of the gut-to-brain axis in defensive responses

Study determines the diagnostic utility of liver stiffness measurement

New insights into the dynamic inner world of the human immune system

Many middle-aged adults unlikely to participate in dementia prevention clinical trials

RSV and kids: What you need to know

First-of-its-kind computer model simulates a clinical trial evaluating two Alzheimer’s drugs

Molecular drug transporters could improve treatment of cancers and other diseases

What is the role of cyclophilin-A in alleviating SARS-CoV-2 infections?

How does imprinted SARS-CoV-2 humoral immunity drive convergent Omicron evolution?

New research lays the foundation for more effectively treating pediatric brain tumor

New method helps gain fundamental insights into ribosome function

New review elucidates current treatment approaches for myelodysplastic syndromes

First preclinical model to study the pathobiology of appendiceal cancer

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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