Antidepressant News and Research

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Antidepressants are medicines that treat depression. Your doctor can prescribe them for you. They can improve your mood, sleep, appetite and concentration. It may take several weeks for them to help. There are several types of antidepressants. You and your doctor may have to try several before finding what works best for you.

Rapastinel demonstrates pro-cognitive benefits in animal model of cognitive impairment

Allergan plc, a leading global pharmaceutical company, announced today that new data on the investigational medication rapastinel (GLYX-13) and its lack of impairment on cognitive function were published in the peer-reviewed journal Behavioural Brain Research.

19 Jan 2016

Inflammation associated with elevated glutamate in the brain could guide depression treatments

Psychiatrists investigating depression have been energized in recent years by reports of rapid, successful treatment with drugs that interfere with the brain chemical glutamate, such as the anesthetic ketamine.

13 Jan 2016

CGP3466B compound may effectively treat depression

The compound CGP3466B, already proven nontoxic for people, may effectively and rapidly treat depression, according to results of a study in mice.

13 Jan 2016

Johns Hopkins researchers show that stroke may increase brain plasticity, recovery in some cases

Using mice whose front paws were still partly disabled after an initial induced stroke, Johns Hopkins researchers report that inducing a second stroke nearby in their brains let them “rehab” the animals to successfully grab food pellets with those paws at pre-stroke efficiency.

8 Jan 2016

Researchers find no evidence that prenatal exposure to antidepressants increases risk for autism, ADHD

An analysis of medical records data from three Massachusetts health care systems finds no evidence that prenatal exposure to antidepressants increases the risk for autism and related disorders or for attention-deficit hyperactivity disorder (ADHD).

6 Jan 2016

Using antidepressant drug during first trimester of pregnancy may increase risk of birth defects

Using paroxetine--a medication prescribed to treat conditions including depression, obsessive-compulsive disorder, anxiety and posttraumatic stress disorder--during the first trimester of pregnancy may increase newborns' risk of congenital malformations and cardiac malformations. That's the conclusion of a recent analysis published in the British Journal of Clinical Pharmacology.

6 Jan 2016

Yale researchers reveal why chronic overeating tied to increased risk of depression

Chronic overeating and stress are tied to an increased risk of depression and anxiety, and in a new study, Yale researchers explain why that happens and suggest a possible solution.

22 Dec 2015

Using antidepressants during pregnancy greatly increases autism risk

Using antidepressants during pregnancy greatly increases the risk of autism, Professor Anick Bérard of the University of Montreal and its affiliated CHU Sainte-Justine children's hospital revealed today. Prof. Bérard, an internationally renowned expert in the fields of pharmaceutical safety during pregnancy, came to her conclusions after reviewing data covering 145,456 pregnancies.

15 Dec 2015

Cognitive behavioral therapy can be equally effective as second generation antidepressant for depression

Major depressive disorder affects more than 32 million Americans, and their first stop for treatment is often their primary care provider. A recent evidence review of several alternatives to medication found that using cognitive behavioral therapy as the first treatment for depression can be equally effective as using a second generation antidepressant.

10 Dec 2015

Novel antidepressant appears to be safe, effective against depression in clinical trial

A small clinical trial of a novel antidepressant that stimulates neurogenesis - the production of new brain cells - shows that the compound appears to be safe and may be effective against depression.

9 Dec 2015

Women with moderate-to-severe PMS at increased risk of developing high blood pressure in later life

In the first prospective study to consider premenstrual syndrome (PMS) as a possible sentinel for future risk of hypertension, epidemiologist Elizabeth Bertone-Johnson and colleagues in the School of Public Health and Health Sciences at the University of Massachusetts Amherst and the Harvard School of Public Health report that women with moderate-to-severe PMS had a 40 percent higher risk of developing high blood pressure over the following 20 years compared to women experiencing few menstrual symptoms.

25 Nov 2015

Misleading symptoms confuse management of older patients with post-HSE relapse

Research shows that teenagers and adults with immune-mediated relapse after herpes simplex encephalitis rarely display the symptoms typically seen in children, delaying the initiation of vital immunotherapy.

3 Nov 2015

Radiocarbon method proves Cameroon’s environment is contaminated with synthetic opioid

Tramadol, a synthetic opioid component of the painkiller tramal, was surprisingly identified in 2013 as a natural product of Sarcocephalus latifolia, a tree found in Cameroon.

31 Oct 2015

Study finds no consistent evidence that antidepressants increase complications after plastic surgery

For patients undergoing plastic surgery procedures, there's no consistent evidence that taking antidepressants increases the risk of bleeding, breast cancer, or other adverse outcomes, concludes a research review in the November issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons.

31 Oct 2015

Risk of depression recurrence significantly lower for people with complete symptom resolution

People who have had an episode of major depression are at high risk for having another episode. Now, researchers at University of California, San Diego School of Medicine have found that the risk of recurrence is significantly lower for people with complete, rather than partial depressive symptom resolution.

28 Oct 2015

More research needed before recommending antidepressants, Alzheimer's disease drugs for stroke recovery: Study

Evidence is mounting that drugs used to treat depression and Alzheimer's disease also can help patients recover from strokes. But there are conflicting findings from studies of these and other drugs given to recovering stroke patients.

22 Oct 2015

Most drug residues discharged to wastewater come from private households

Most drug residues discharged to wastewater come from private households. As contributors of pollution by Active Pharmaceutical Ingredients (APIs), health establishments, such as hospitals, psychiatric and nursing facilities are hardly worth mentioning.

20 Oct 2015

Scientists reveal link between depression and paraventricular thalamus

Scientists from the RIKEN Brain Science Institute have shown that a mouse strain with a mutation that leads to dysfunction of mitochondria--the "powerhouses" that provide energy to cells--spontaneously undergo periodic episodes of depression-like behavior that resemble those in human. Through this research, published in Molecular Psychiatry, the scientists uncovered a link between depression and the paraventricular thalamus, a region of the brain not previously tied to depression.

20 Oct 2015

Consuming high-fat diet may lead to anxiety and depression, cause measurable changes in the brain

A new study in mice reveals that increased body weight and high blood sugar as a result of consuming a high-fat diet may cause anxiety and depressive symptoms and measurable changes in the brain.

20 Oct 2015

Two-drug combination relieves depression in older adults

More than half of older adults with clinical depression don't get better when treated with an antidepressant. But results from a multicenter clinical trial that included Washington University School of Medicine in St. Louis indicates that adding a second drug — an antipsychotic medication — to the treatment regimen helps many of those patients.

28 Sep 2015

Antidepressant News and Research

Further Reading

Rapastinel demonstrates pro-cognitive benefits in animal model of cognitive impairment

Inflammation associated with elevated glutamate in the brain could guide depression treatments

CGP3466B compound may effectively treat depression

Johns Hopkins researchers show that stroke may increase brain plasticity, recovery in some cases

Researchers find no evidence that prenatal exposure to antidepressants increases risk for autism, ADHD

Using antidepressant drug during first trimester of pregnancy may increase risk of birth defects

Yale researchers reveal why chronic overeating tied to increased risk of depression

Using antidepressants during pregnancy greatly increases autism risk

Cognitive behavioral therapy can be equally effective as second generation antidepressant for depression

Novel antidepressant appears to be safe, effective against depression in clinical trial

Women with moderate-to-severe PMS at increased risk of developing high blood pressure in later life

Misleading symptoms confuse management of older patients with post-HSE relapse

Radiocarbon method proves Cameroon’s environment is contaminated with synthetic opioid

Study finds no consistent evidence that antidepressants increase complications after plastic surgery

Risk of depression recurrence significantly lower for people with complete symptom resolution

More research needed before recommending antidepressants, Alzheimer's disease drugs for stroke recovery: Study

Most drug residues discharged to wastewater come from private households

Scientists reveal link between depression and paraventricular thalamus

Consuming high-fat diet may lead to anxiety and depression, cause measurable changes in the brain

Two-drug combination relieves depression in older adults

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