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Mast cells play a crucial role in the development of chronic myeloid leukemia

Chronic myeloid leukemia (CML) is a type of blood cancer that arises from malignant changes in blood-forming cells of the bone marrow.

16 May 2023

UArizona Health Sciences researchers seek to improve opioid therapy while decreasing its side effects

University of Arizona Health Sciences researchers are taking the foot off the brake in their quest to improve opioid therapy while decreasing its side effects.

15 May 2023

Carotenoids' potential in reducing chronic disease risk

Researchers explore the association between the gastrointestinal delivery system and carotenoids.

15 May 2023

Leveraging proteomics datasets to discover potential therapeutic targets for cancer patients

A new research perspective was published in Oncotarget's Volume 14 on May 4, 2023, entitled, "Using cancer proteomics data to identify gene candidates for therapeutic targeting."

10 May 2023

Boosting gut health with short-chain fatty acids

Research paper provides an overview of short-chain fatty acids (SCFAs) and their role in regulating gut homeostasis. It also discusses SCFA-producing bacteria and potential therapeutic approaches to boost SCFA levels in the gut to treat related diseases.

9 May 2023

Anticoronavirals: the development of COVID-19 therapies and the challenges that remain

Researchers highlighted the pace of development of COVID-19 therapies during the pandemic and the challenges that hinder the widespread availability of anticoronavirals.

8 May 2023

Organoid models provide new scientific insights into a rare childhood liver cancer

Scientists of the Princess Máxima Center for pediatric oncology and Hubrecht Institute in the Netherlands have revealed new scientific insights into the features of fibrolamellar carcinoma (FLC), a rare type of childhood liver cancer

3 May 2023

Study sheds new light on the role of somatic mutations in temporal lobe epilepsy

Epilepsy affects approximately 1-in-26 people and the most common form, known as temporal lobe epilepsy (TLE), often cannot be adequately treated with anti-seizure medications.

2 May 2023

Researchers discover a key player in preventing 'insulin shock'

Just over a century has passed since the discovery of insulin, a time period during which the therapeutic powers of the hormone have broadened and refined. Insulin is an essential treatment for type 1 diabetes and often for type 2 diabetes, as well.

24 Apr 2023

Study reveals CMPK-2 protein-coding gene as a potent inhibitor of flaviviruses

CMPK2 identified as a potential pan-flavivirus inhibitor, restricting virus replication and providing a basis for developing new antiviral treatments.

23 Apr 2023

Study reveals DCAF1 protein's role in colon cancer development through EZH2 phosphorylation

A recent study reveals that DCAF1 is overexpressed and phosphorylates EZH2 in colon cancer cells.

18 Apr 2023

A review of the risk factors associated with cancer evolution

Researchers reviewed existing data on tumor-promotive risk factors and their underlying mechanisms.

17 Apr 2023

Antioxidant-rich phenolic compounds: A key to disease prevention, gut health, and brain homeostasis

Researchers report on the benefits of consuming dietary phenols and their relationship with the intestinal microbiome.

10 Apr 2023

Mediterranean diet and the modulation of mitochondrial function

Researchers reviewed the current knowledge related to the Mediterranean diet (MedDiet) and the role of mitochondria concerning health outcomes.

7 Apr 2023

Pathophysiology, comorbidities, and interventions related to childhood obesity

Researchers discuss the psychological and physiological impacts of obesity on children.

6 Apr 2023

How nanomedicine is revolutionizing care for cardiovascular disease

Researchers review recent advancements in nanomedicine treatment options for cardiovascular disease.

6 Apr 2023

Novel combination treatment for head and neck cancers leads to antitumor effects

Human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) and lung cancer can have disruptive mutations in TP53and/or CDKN2A tumor suppressor genes, which are associated with poor patient survival.

5 Apr 2023

Novel molecule may help overcome the devastating symptoms of Duchenne muscular dystrophy

In a new study published in The FASEB Journal, investigators demonstrated the potential of a molecule that may help overcome some of the devastating symptoms of Duchenne muscular dystrophy (DMD), the most common life-limiting congenital neuromuscular disorder.

5 Apr 2023

Clinical trial may change the paradigm of care for patients with ALK-driven high-risk neuroblastoma

In a significant step for the treatment of neuroblastoma, an international group of researchers led by Children's Hospital of Philadelphia (CHOP), Winship Cancer Institute of Emory University and the New Approaches to Neuroblastoma Therapy (NANT) Consortium has shown that the targeted therapy lorlatinib is safe and effective in treating high-risk neuroblastoma.

4 Apr 2023

What role do dietary lipids play in the gut-brain axis in type 2 diabetes mellitus?

Researchers examined the significance of dietary lipids in the gut-brain axis of individuals with T2DM.