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TRF1 protein depletion linked to leaner mice and altered metabolism

A new research paper was published in Volume 17, Issue 9 of Aging-US on September 17, 2025, titled "Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles."

27 Oct 2025

Pigments extracted from the henna dye could be used to treat liver disease

Lawsonia inermis is best known for making henna, a versatile dye that is used to change the color of skin and clothes. Now, researchers from Osaka Metropolitan University have found another use for the pigments extracted from the dye: treating liver disease.

27 Oct 2025

Doctors muffled as Florida moves to end decades of childhood vaccination mandates

Florida plans to end nearly a half-century of required childhood immunizations against diseases that have killed and maimed millions of children. Many critics of the decision, including doctors, are afraid to speak up against it.

27 Oct 2025

Mitochondria and lysosomes work together to control regulatory T cell activation

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system.

24 Oct 2025

Researchers map the complex sugar chains attached to rat serum proteins

A comprehensive study mapped the dynamic glycosylation landscape of rat serum proteins, uncovering sex- and time-dependent variations with clear cell-type specificity.

24 Oct 2025

New York Regional Diabetes Research Center established with $10.8 million NIH grant

Albert Einstein College of Medicine has received a five-year, $10.8 million grant from the National Institutes of Health (NIH) to create the New York Regional Diabetes Research Center (NYR-DRC), a newly expanded multi-institutional center co-led with the Icahn School of Medicine at Mount Sinai and Weill Cornell Medicine.

23 Oct 2025

Common chemical tetrachloroethylene may be harmful to the liver

Liver disease is usually caused by one of three factors: alcohol consumption, fat buildup in the liver linked to obesity, diabetes and high cholesterol, or hepatitis B and C.

23 Oct 2025

Analysis highlights the differing physical side effects of antidepressants

Antidepressants can differ widely in how they physically affect the body, including around a 4 kg difference in weight change between certain drugs (approximately 2.5 kg weight loss from agomelatine and 2kg weight gain from maprotiline), confirms a systematic review and meta-analysis published in The Lancet.

22 Oct 2025

E2F2 protein identified as potential therapeutic target to prevent metabolic fatty liver disease progression

An international collaborative study has identified the E2F2 protein as a potential new therapeutic target to prevent metabolic fatty liver disease from progressing towards more serious conditions, such as cirrhosis or liver cancer.

22 Oct 2025

Groundbreaking 3D dynamic cell co-culture models simulate MASLD progression

In a recent work published in BME Frontiers, a collaborative study by researchers from Griffith University, Queensland University of Technology, University of Queensland, and Nanjing Stomatological Hospital has introduced groundbreaking three-dimensional (3D) dynamic cell co-culture models to simulate metabolic dysfunction-associated steatotic liver disease (MASLD) progression stages.

22 Oct 2025

New drug combination shows promise in treating colorectal cancer

Colorectal cancer is one of the most common tumors among people over the age of 50. Although it is known to develop from small lesions or polyps, its exact causes are unknown — only a few risk factors are known — and it is usually treated with surgery, chemotherapy and radiotherapy, or biological therapies.

22 Oct 2025

Scientists question the safety and efficacy of the diet for metabolic health

A study published in Science Advances by University of Utah Health researchers sheds light on the long-term effects of the ketogenic diet, raising important questions about its safety and efficacy for improving metabolic health.

22 Oct 2025

Baby's birthweight increases risk of cardiovascular disease in preeclamptic and hypertensive women

A new study shows that preeclamptic and hypertensive pregnant women's risk of getting cardiovascular disease is linked to their baby's birthweight.

21 Oct 2025

AGA updates guidelines for Barrett's Esophagus to catch cancer early

The American Gastroenterological Association (AGA) released a new clinical practice guideline on the surveillance of Barrett's esophagus, the only known precursor to esophageal cancer (adenocarcinoma), a highly lethal cancer whose incidence has risen substantially over recent decades.

21 Oct 2025

Transdermal hormone therapy offers potential reduction in anxiety and depression

Hormone therapy–oral and transdermal–remains the most effective treatment for such bothersome menopause symptoms as hot flashes and is generally considered safe for most patients. A new study shows that risk profiles are different based on how the hormones are administered.

21 Oct 2025

Largest trial of adjuvant pembrolizumab in Merkel cell carcinoma reports key benefit

A new cancer clinical trial by the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) shows that a drug that utilizes the body's immune system to target and eliminate cancer cells appeared to reduce the risk of distant metastases for an aggressive form of skin cancer when given immediately after surgery, but did not significantly reduce the overall risk of recurrence, which was a co-primary endpoint of the trial.

21 Oct 2025

MRI age clocks reveal how each organ ages differently and predict who develops disease or lives longer

Researchers developed seven MRI-based biological age clocks across major organs using UK Biobank imaging, linking each to proteins, metabolites, genetics, disease risks, mortality, and cognitive decline. These organ-specific age gaps reveal how uneven aging shapes vulnerability to conditions such as diabetes, hypertension, and dementia, opening new paths for precision prevention and clinical trial stratification

19 Oct 2025

Nanoparticles offer new hope for treating alcohol-related liver disease

Across the world, more than 1.5 billion people suffer from chronic liver disease. The U.S. Centers for Disease Control and Prevention reports that it kills more than 52,000 people a year in the United States alone - the ninth most common cause of death in the nation.

17 Oct 2025

People's heart health unlikely to be affected by some industrially processed hard fats

Two types of industrially processed hard fats, widely used in everyday foods such as bakery products, margarines and spreads, are unlikely to affect heart health when consumed in levels achievable in most people's diets.

17 Oct 2025

Study: Hidden fat inside the abdomen and liver may damage arteries

A new study led by researchers at McMaster University reveals that hidden fat deep inside the abdomen and liver may quietly damage arteries, even in people who appear healthy.

17 Oct 2025

Liver News and Research

TRF1 protein depletion linked to leaner mice and altered metabolism

Pigments extracted from the henna dye could be used to treat liver disease

Doctors muffled as Florida moves to end decades of childhood vaccination mandates

Mitochondria and lysosomes work together to control regulatory T cell activation

Researchers map the complex sugar chains attached to rat serum proteins

New York Regional Diabetes Research Center established with $10.8 million NIH grant

Common chemical tetrachloroethylene may be harmful to the liver

Analysis highlights the differing physical side effects of antidepressants

E2F2 protein identified as potential therapeutic target to prevent metabolic fatty liver disease progression

Groundbreaking 3D dynamic cell co-culture models simulate MASLD progression

New drug combination shows promise in treating colorectal cancer

Scientists question the safety and efficacy of the diet for metabolic health

Baby's birthweight increases risk of cardiovascular disease in preeclamptic and hypertensive women

AGA updates guidelines for Barrett's Esophagus to catch cancer early

Transdermal hormone therapy offers potential reduction in anxiety and depression

Largest trial of adjuvant pembrolizumab in Merkel cell carcinoma reports key benefit

MRI age clocks reveal how each organ ages differently and predict who develops disease or lives longer

Nanoparticles offer new hope for treating alcohol-related liver disease

People's heart health unlikely to be affected by some industrially processed hard fats

Study: Hidden fat inside the abdomen and liver may damage arteries

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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