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Scientists use novel technology for opening blood-brain barrier with implantable ultrasound

One of most potent drugs for treatment of glioblastoma, the most deadly type of brain tumor, can't be used in patients because of two problems. First, it can't reach its target because it's blocked by the blood-brain barrier, a microscopic structure that protects the brain from toxins in the blood. And the conventional formulation for this drug is toxic to the brain.

12 Dec 2019

Depression and anxiety can have negative impact on outcomes following hip surgery

New research suggests that physicians evaluating young patients with hip pain should consider more than such patients' physical health. They also should consider screening those patients for clinical depression and anxiety -- impairments that researchers at Washington University School of Medicine in St. Louis have found can have a negative impact on outcomes following hip surgery, such as pain, slower recoveries and inadequate return to activity.

12 Dec 2019

Mount Sinai Kravis Children's Hospital receives new grant to support "Paws & Play" program

Mount Sinai Kravis Children's Hospital announced today that PetSmart Charities has offered a gift of $75,000 to extend the tenure of Professor Bunsen Honeydew the hospital's first of three facility dogs, through October 2020.

12 Dec 2019

Battling the bullets from the operating room to the community

Dr. Laurie Punch plunged her gloved hands into Sidney Taylor's open chest in a hospital’s operating room here, pushing on his heart to make it pump again after a bullet had torn through his flesh, collarbone and lung. His pulse had faded to nothing. She needed to get his heart beating.

12 Dec 2019

Radiation therapy alone found to be cost-effective for treatment of DCIS

Ductal carcinoma in-situ (DCIS) accounts for one-fifth of breast cancer cases in the United States, according to the American Cancer Society.

11 Dec 2019

NCCN Patient Advocacy Summit closes gaps in perspective of value in cancer care

The National Comprehensive Cancer Network (NCCN) hosted an annual NCCN Patient Advocacy Summit: Delivering Value for Patients across the Oncology Ecosystem in Washington, DC, today.

11 Dec 2019

Researchers develop new bio-platform to hear the beat of small clusters of cells

One of the tests that almost every patient must face before a surgery or other health intervention is an electrocardiogram.

11 Dec 2019

New drug combo promises help for triple negative breast cancer patients

A new preclinical study on triple negative breast cancer (TNBC) reports that an experimental polo-like kinase 1 (PLK1) inhibitor shrank tumor four times more powerfully when used along with standard drugs than alone. The study, reported in the journal PLOS ONE, opens up a new door of opportunity for patients with this disease.

11 Dec 2019

Scientists evaluate mouse models used for developing new treatments for Huntington's disease

Huntington's disease (HD) is an incurable and fatal hereditary disease. Developing disease-modifying drugs to treat patients with HD depends on studying them in animal models. Scientists evaluated the mouse models used for developing new treatments for mood disorders in HD and recommended which of these models are most relevant to their studies.

11 Dec 2019

Jefferson hotspotting program uses team-based model to addresses hospital 'super utilizers'

The United States faces a crisis in providing complex care for high-need, high-cost individuals--people who often suffer economic, mental and physical challenges.

11 Dec 2019

Blood test could be a better way of guiding treatment for advanced breast cancer patients

A blood test can help identify rare mutations in advanced breast cancer, which may enable patients to access effective treatments more quickly in the future, Cancer Research UK scientists have found.

11 Dec 2019

Genetic variant mainly found in individuals of African ancestry increases odds of heart failure

A genetic variant in the gene transthyretin (TTR)- which is found in about 3 percent of individuals of African ancestry- is a more significant cause of heart failure than previously believed, according to a multi-institution study led by researchers at Penn Medicine.

10 Dec 2019

Children in low resourced countries more likely to die after surgery

Children in low resourced countries are 100-200 times more likely to die after surgery than children in wealthy countries, according to a first-of-its-kind study published in Anesthesiology.

10 Dec 2019

Fresh red blood cell transfusions are no more beneficial than older ones to critically ill children

A new study led by the Sainte-Justine University Hospital Centre and the University of Montreal, along with the Washington University School of Medicine in St. Louis, has found that transfusions using fresh red blood cells--cells that have spent seven days or less in storage--are no more beneficial than older red blood cells in reducing the risk of organ failure or death in critically ill children.

10 Dec 2019

Combination regimen shows promising results in preclinical models of triple negative breast cancer

Tumor volume in a preclinical model of triple negative breast cancer (TNBC) was reduced four times more when an experimental polo-like kinase 1 (PLK1) inhibitor was combined with a standard-of-care chemotherapeutic agent than when the agent was used alone.

10 Dec 2019

Mitochondrial dysfunction may underlie prolonged muscle weakness after sepsis

Damage to energy-producing mitochondria may underlie prolonged muscle weakness following a sepsis-like condition in mice, according to a new study published today in eLife.

10 Dec 2019

Retrospective review: Proton therapy well tolerated in patients undergoing breast conserving surgery

While the assessment of proton therapy in breast cancer treatment continues through clinical trials, data relating to early toxicity and cosmetic outcomes for this population are limited.

9 Dec 2019

New nanoparticle innovation detects vascular calcification in atherosclerosis

Heart disease and stroke are the world's two most deadly diseases, causing over 15 million deaths in 2016 according to the World Health Organization.

9 Dec 2019

Innovative experimental therapy may stop growth of triple-negative breast cancer

Mount Sinai researchers have designed an innovative experimental therapy that may be able to stop the growth of triple-negative breast cancer, the deadliest type of breast cancer, which has few effective treatment options, according to a study published in Nature Chemical Biology in December.

9 Dec 2019

High HIV infection rates attributed to transgender community's social stigmatization and isolation

Although HIV infection rates are high among the transgender community in Russia, many transgender people know very little about the virus, as well as their own health status.

9 Dec 2019

Surgery News and Research

Scientists use novel technology for opening blood-brain barrier with implantable ultrasound

Depression and anxiety can have negative impact on outcomes following hip surgery

Mount Sinai Kravis Children's Hospital receives new grant to support "Paws & Play" program

Battling the bullets from the operating room to the community

Radiation therapy alone found to be cost-effective for treatment of DCIS

NCCN Patient Advocacy Summit closes gaps in perspective of value in cancer care

Researchers develop new bio-platform to hear the beat of small clusters of cells

New drug combo promises help for triple negative breast cancer patients

Scientists evaluate mouse models used for developing new treatments for Huntington's disease

Jefferson hotspotting program uses team-based model to addresses hospital 'super utilizers'

Blood test could be a better way of guiding treatment for advanced breast cancer patients

Genetic variant mainly found in individuals of African ancestry increases odds of heart failure

Children in low resourced countries more likely to die after surgery

Fresh red blood cell transfusions are no more beneficial than older ones to critically ill children

Combination regimen shows promising results in preclinical models of triple negative breast cancer

Mitochondrial dysfunction may underlie prolonged muscle weakness after sepsis

Retrospective review: Proton therapy well tolerated in patients undergoing breast conserving surgery

New nanoparticle innovation detects vascular calcification in atherosclerosis

Innovative experimental therapy may stop growth of triple-negative breast cancer

High HIV infection rates attributed to transgender community's social stigmatization and isolation

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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