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Durvalumab plus chemotherapy improved overall survival rate for mesothelioma patients

PrECOG, LLC is reporting clinical efficacy and biomarker analyses from its single-arm phase two study PrE0505 for the initial treatment of patients with malignant pleural mesothelioma.

20 May 2020

Molecular testing rates in most countries less than 50%, IASLC survey finds

Access to targeted therapies for lung cancer depends on accurate identification of patients' biomarkers through molecular testing, but survey results published today in the Journal of Thoracic Oncology suggest that many international clinicians are unaware of evidence-based guidelines that support the use of molecular testing.

20 May 2020

New technique reveals potentially treatable mutations in subset of prostate cancer patients

Prostate cancer patients who do not respond well to PSMA-targeted therapy often have potentially treatable mutations in their DNA damage-repair genes, according to research published in the May issue of The Journal of Nuclear Medicine.

20 May 2020

Scientists develop novel flow cytometry technique to quantify protein production in T-cells

A team of scientists from Hollings Cancer Center at the Medical University of South Carolina (MUSC) has developed a novel flow cytometry technique that can, for the first-time, quantify protein production in T-cells.

20 May 2020

'Senolytic' therapy blunts liver tumor progression in animal models

"Senotherapy," a treatment that uses small molecule drugs to target "senescent" cells, or those cells that no longer undergo cell division, blunts liver tumor progression in animal models according to new research from a team led by Celeste Simon, Ph.D., a professor of Cell and Developmental Biology in the Perelman School of Medicine at the University of Pennsylvania and scientific director of the Abramson Family Cancer Research Institute.

20 May 2020

Researchers report a new way to stabilize liposomes

For decades, scientists have explored the use of liposomes –– hollow spheres made of lipid bilayers –– to deliver chemotherapy drugs to tumor cells.

20 May 2020

USC-Olympus partnership in multiscale bioimaging furthers precision medicine

As a global leader in endoscopy and life science solutions, Olympus has long been committed to promoting awareness of cancer screening, prevention and testing. In this spirit, the company recently forged a partnership with the Lawrence J. Ellison Institute for Transformative Medicine at the University of Southern California (USC).

From Evident Corporation - Life Sciences 20 May 2020

Study examines 5-aminolevulinic acid induced fluorescence in surgery of brain metastases

Two-thirds of brain metastases give off fluorescence following administration of 5-aminolevulinic acid, which could potentially assist surgeons in identifying such tumors.

20 May 2020

Study could help identify more targeted treatments for ovarian cancer

The rogue cellular engine that drives a majority of ovarian cancers remains frustratingly difficult to disable. A new study comparing cancerous tissue with normal fallopian tube samples advances important insights about this machinery and confirms biological hallmarks of survival.

20 May 2020

Understanding why pancreatic ductal adenocarcinoma is so aggressive

Pancreatic ductal adenocarcinoma (PDA) is a deadly cancer, killing patients within a year. CSHL Professor Christopher Vakoc and his former postdoc Timothy Somerville discovered how pancreatic cells lose their identity, acquire a deadly new identity, and recruit nearby cells to help them grow, promote inflammation, and invade nearby tissues.

19 May 2020

Phase IIB clinical trial initiated for treating hepatitis B-associated liver cancer

The first patients have been dosed in a multi-regional Phase IIB randomized, placebo-controlled clinical trial for the treatment of hepatitis B-associated liver cancer.

19 May 2020

Innovent Biologics and MD Anderson to develop sintilimab injection for rare cancers

The University of Texas MD Anderson Cancer Center and Innovent Biologics, Inc. today announced a strategic collaboration agreement to co-develop TYVYT® (sintilimab injection), Innovent's anti-PD-1 monoclonal antibody, in rare cancers in the U. S...

19 May 2020

Study shows how normal RAS interacts with mutated RAS in living cells

Many cancer medications fail to effectively target the most commonly mutated cancer genes in humans, called RAS.

19 May 2020

Multi-institutional clinical trial sheds new light on non-responsive tumors

Over the last decade, enzalutamide and similar drugs have led to significant tumor control and increased survival time for men who have metastatic prostate cancer that continues to grow despite treatments to reduce male hormone levels.

19 May 2020

Study shows how cancer protein changes may accelerate tumorigenesis and metastasis

Understanding the genetic mutations and protein changes that take place in the progression of cancer is key to its treatment. Mutations in the gene TP53 and concomitant mutant p53 proteins in cancer cells have become notorious over the course of multiple studies of several different types of cancers.

18 May 2020

New analysis links DNA variations to risks of specific breast cancer subtypes

An analysis of genetic studies covering 266,000 women has revealed 32 new sites on the human genome where variations in DNA appear to alter the risks of getting breast cancer.

18 May 2020

Novel microRNA biomarker could help detect lymph node metastases in pancreatic cancer patients

For years, surgeons have operated on pancreatic cancer patients to remove what they thought was a localized tumor only to discover that the disease had spread to other, inoperable parts of the body. Now, a City of Hope molecular scientist thinks he may have found a way to prevent ineffective surgeries and prolong the lives of these patients.

18 May 2020

Potential new treatment approach to fatal COVID-19

Researchers from the University of Colorado Anschutz Medical Campus and Pathways Bioscience in the United States have found that activating a transcription factor involved in oxidative stress regulation, antiviral activity, and inflammation may serve as a new treatment approach to coronavirus disease 2019 (COVID-19).

18 May 2020

A new tool to study and map the intricacies of intercellular signaling

How do cells move? Why do they move? Why do some cancer cells move slowly while others move quickly, causing a cancerous tumor to metastasize and become much more difficult to treat effectively?

18 May 2020

Cancer biologists identify important drivers of tumor resistance

Cancer biologists at the Mays Cancer Center, home to UT Health San Antonio MD Anderson, have identified important drivers that enable tumors to change their behavior and evade anticancer therapies.

18 May 2020

Tumor News and Research

Durvalumab plus chemotherapy improved overall survival rate for mesothelioma patients

Molecular testing rates in most countries less than 50%, IASLC survey finds

New technique reveals potentially treatable mutations in subset of prostate cancer patients

Scientists develop novel flow cytometry technique to quantify protein production in T-cells

'Senolytic' therapy blunts liver tumor progression in animal models

Researchers report a new way to stabilize liposomes

USC-Olympus partnership in multiscale bioimaging furthers precision medicine

Study examines 5-aminolevulinic acid induced fluorescence in surgery of brain metastases

Study could help identify more targeted treatments for ovarian cancer

Understanding why pancreatic ductal adenocarcinoma is so aggressive

Phase IIB clinical trial initiated for treating hepatitis B-associated liver cancer

Innovent Biologics and MD Anderson to develop sintilimab injection for rare cancers

Study shows how normal RAS interacts with mutated RAS in living cells

Multi-institutional clinical trial sheds new light on non-responsive tumors

Study shows how cancer protein changes may accelerate tumorigenesis and metastasis

New analysis links DNA variations to risks of specific breast cancer subtypes

Novel microRNA biomarker could help detect lymph node metastases in pancreatic cancer patients

Potential new treatment approach to fatal COVID-19

A new tool to study and map the intricacies of intercellular signaling

Cancer biologists identify important drivers of tumor resistance

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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