Clinical Trial News and Research

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Study yields therapeutic clues to combat drug resistance in rare aggressive cancer

Stephen Elledge, PhD, and his team did not set out to find therapies that could render tumors less resistant to therapy or make existing drugs more potent against a rare form of cancer. But these are precisely the clinical insights that their most recent study has yielded.

29 Aug 2018

New study reports key steps towards development of acne vaccine

A new study published in the Journal of Investigative Dermatology reports important steps that have been taken towards the development of an acne vaccine.

29 Aug 2018

Novel tests to better assess earlier stages of AMD

The European MACUSTAR consortium is conducting a multi-country clinical study on age-related macular degeneration coordinated by the University of Bonn.

29 Aug 2018

Using novel gene therapy to cure infants born with severe combined immunodeficiency

Out of every 60,000 births, a baby arrives to face the world without a fully functioning immune system leaving them unequipped to fight even the most common infections.

29 Aug 2018

Researchers receive $6 million NIH grant to improve treatment for Chagas disease

Scientists at The University of Texas at El Paso have received nearly $6 million from the National Institutes of Health to improve treatment and develop new diagnostic tools to assess post-therapeutic outcomes for patients with Chagas disease.

29 Aug 2018

Hesperos receives SBIR grant to create ‘human-on-a-chip’ model to mimic Alzheimer's disease

Hesperos, Inc., announced today the receipt of a NIH Phase I Small Business Innovation Research grant from the National Institutes of Health National Institute on Aging to help create a new multi-organ "human-on-a-chip" model that can realistically mimic the biology of Alzheimer's Disease and the effects of potential new therapies under realistic human physiological conditions.

29 Aug 2018

Researchers discover reason why many bladder cancer patients do not respond to immunotherapy

Mount Sinai researchers have discovered that a particular type of cell present in bladder cancer may be the reason why so many patients do not respond to the groundbreaking class of drugs known as PD-1 and PD-L1 immune checkpoint inhibitors, which enable the immune system to attack tumors.

29 Aug 2018

Research shows proteomics can be used to predict evolution of triple negative breast cancer

The rarest, but also the most aggressive and hard to treat form of breast cancer, is known as triple negative. For this type of cancer, researchers have so far been unable to identify markers that can classify patients by prognosis or probability of responding to different treatments.

29 Aug 2018

Change in type of breathing tube used for resuscitation can improve odds of survival

A new study showed that a change in the type of breathing tube paramedics use to resuscitate patients with sudden cardiac arrest can significantly improve the odds of survival and save thousands of lives.

29 Aug 2018

Drug used for chest pain does not decrease chance of first occurrence of ventricular arrhythmias

A clinical trial of more than 1,000 patients with implantable cardioverter defibrillators found that the drug ranolazine was safe but didn't significantly decrease the likelihood of the first occurrence of ventricular tachycardia, ventricular fibrillation or death in this high-risk population.

29 Aug 2018

Major bleeding associated with subsequent cancer diagnoses

Bleeding in patients treated with anticoagulants should stimulate a search for cancer, according to late breaking results from the COMPASS trial presented today at ESC Congress 2018.

28 Aug 2018

Blood pressure lowering therapy and statins continue to improve survival in patients with hypertension

Blood pressure and cholesterol lowering drugs continue to improve survival in patients with hypertension after more than a decade, according to late breaking results from the ASCOT Legacy study presented at ESC Congress 2018 and published in The Lancet.

28 Aug 2018

New system that uses AI accurately detects patients with diabetic retinopathy

A system designed by a University of Iowa ophthalmologist that uses artificial intelligence to detect diabetic retinopathy without a person interpreting the results earned Food and Drug Administration authorization in April, following a clinical trial in primary care offices.

28 Aug 2018

TB Alliance initiates SimpliciTB to test if new four-drug regimen can treat most types of tuberculosis

TB Alliance has initiated a pivotal clinical trial, SimpliciTB, that will evaluate whether a new four-drug regimen can treat most types of tuberculosis including multidrug-resistant TB more quickly and effectively than currently-available treatments.

28 Aug 2018

New minimally-invasive surgical technique may be most significant development in dialysis

A new minimally-invasive surgical technique for dialysis patients may be the most significant development in dialysis access in the last 50 years, according to the surgeon who performed the first two cases in the United States.

28 Aug 2018

Researchers launch clinical trial to assess new drug combination against metastatic breast cancers

Researchers at University of California San Diego School of Medicine have launched a phase Ib clinical trial to assess the safety and tolerability of cirmtuzumab, in combination with standard chemotherapy, to treat metastatic or locally advanced breast cancer that cannot be surgically removed.

28 Aug 2018

Daily use of aspirin does not reduce occurrence of major cardiovascular events, finds ARRIVE trial

The role of aspirin in preventing a first heart attack or stroke among people at moderate risk of heart disease remains unclear.

28 Aug 2018

Researchers reveal an unlikely protector against growth of metastatic breast cancer

At the time of initial diagnosis, most patients with breast cancer show no signs that their cancer has spread elsewhere in the body. Yet, up to 30 percent of patients will ultimately experience metastasis, with breast cancer taking root and growing at other sites in the body, sometimes months, years or even decades later.

27 Aug 2018

UIC receives $7 million for developing programs to prevent adolescent depression

The University of Illinois at Chicago has been awarded $7 million in funding from the Patient-Centered Outcomes Research Institute to develop programs to prevent depression among teens.

27 Aug 2018

Amphetamine regimen does not improve post-stroke motor recovery

A pilot clinical trial exploring the benefit of d-amphetamine combined with physical therapy for stroke patients found no evidence that the regimen improved post-stroke motor recovery.

27 Aug 2018

Clinical Trial News and Research

Study yields therapeutic clues to combat drug resistance in rare aggressive cancer

New study reports key steps towards development of acne vaccine

Novel tests to better assess earlier stages of AMD

Using novel gene therapy to cure infants born with severe combined immunodeficiency

Researchers receive $6 million NIH grant to improve treatment for Chagas disease

Hesperos receives SBIR grant to create ‘human-on-a-chip’ model to mimic Alzheimer's disease

Researchers discover reason why many bladder cancer patients do not respond to immunotherapy

Research shows proteomics can be used to predict evolution of triple negative breast cancer

Change in type of breathing tube used for resuscitation can improve odds of survival

Drug used for chest pain does not decrease chance of first occurrence of ventricular arrhythmias

Major bleeding associated with subsequent cancer diagnoses

Blood pressure lowering therapy and statins continue to improve survival in patients with hypertension

New system that uses AI accurately detects patients with diabetic retinopathy

TB Alliance initiates SimpliciTB to test if new four-drug regimen can treat most types of tuberculosis

New minimally-invasive surgical technique may be most significant development in dialysis

Researchers launch clinical trial to assess new drug combination against metastatic breast cancers

Daily use of aspirin does not reduce occurrence of major cardiovascular events, finds ARRIVE trial

Researchers reveal an unlikely protector against growth of metastatic breast cancer

UIC receives $7 million for developing programs to prevent adolescent depression

Amphetamine regimen does not improve post-stroke motor recovery

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