Bioinformatics News and Research

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Bioinformatics is the application of information techniques for the storage, retrieval, and analysis of large quantities of biological data.

Novel targets for treating sorafenib-resistant hepatocellular carcinoma found using CRISPR-Cas9 screening

This study is led by Xiujun Cai (Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine). Professor Xiujun Cai's research team screened the whole genome of hepatocellular carcinoma cells (HepG2) through CRISPR / cas9 system under sorafenib treatment, and screened the dominant gene in sorafenib resistance.

20 Apr 2022

Report provides recommendations to help prevent or mitigate economic challenges during future public health emergencies

The Association for Molecular Pathology, the premier global, molecular diagnostic professional society, today released a report entitled "Economics of Clinical Testing during a Public Health Emergency: Lessons Learned from Two Years of COVID-19."

19 Apr 2022

Wearables can identify changes in physiological systems during COVID-19 disease progression

If you become ill with COVID-19, your smartwatch can track the progression of your symptoms, and could even show how sick you become.

19 Apr 2022

Researchers investigate COVID-19 data with logistic regression model training

A new study investigated how logistic regression model training affects performance, and which features are best to include when examining datasets from individuals suffering from COVID-19.

19 Apr 2022

New bioinformatics platform predicts optimal treatment combinations for cancer patients

Researchers at The University of Texas MD Anderson Cancer Center have developed a new bioinformatics platform that predicts optimal treatment combinations for a given group of patients based on co-occurring tumor alterations.

12 Apr 2022

Certain antirheumatic drugs may lower incidence of Alzheimer's and related dementias in people with cardiovascular disease

New findings from the ongoing Drug Repurposing for Effective Alzheimer's Medicines (DREAM) study suggest that certain rheumatoid arthritis drugs may lower incidence of Alzheimer's disease and related dementias in people with cardiovascular disease.

8 Apr 2022

Researchers develop universal AI algorithm to "clean" noisy single-cell RNA sequencing data

Just as asking a single person about their health will provide tailored, personalized information impossible to glean from a large poll, an individual cell's genome or transcriptome can provide much more information about their place in living systems than sequencing a whole batch of cells.

7 Apr 2022

Researchers obtain a treasure trove of new data about RNA viruses from ocean water samples

Ocean water samples collected around the world have yielded a treasure trove of new data about RNA viruses, expanding ecological research possibilities and reshaping our understanding of how these small but significant submicroscopic particles evolved.

7 Apr 2022

Evidence SARS-CoV-2 undergoes ADAR-mediated A-to-I RNA editing in human cells

In a recent study published in the journal PLOS Genetics, researchers explored severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) ribonucleic acid (RNA) editing in host cells.

4 Apr 2022

Groundbreaking collaborative work defines the risk of SARS-CoV-2 variants on immune protection

In a paper in the journal Nature, Los Alamos National Laboratory scientists Bette Korber, Hyejin Yoon, Will Fischer and James Theiler, among nearly 130 authors from institutions around the world, describe their groundbreaking collaborative work, "Defining the risk of SARS-CoV-2 variants on immune protection."

1 Apr 2022

NIH program provides a real-time risk assessment of variants of SARS-CoV-2

Faculty from the Departments of Microbiology, Medicine Genetics and Genomic Sciences, and Pathology and Molecular Cell-Based Medicine at the Icahn School of Medicine at Mount Sinai play key roles in a National Institutes of Health (NIH) program set up to provide a real-time risk assessment of variants of SARS-CoV-2, the virus that causes COVID-19. The program, called SARS-CoV-2 Assessment of Viral Evolution (SAVE) and described in a paper published March 31 in Nature, assesses how the variants might affect transmission, virulence, and resistance to both disease-induced (convalescent) and vaccine-induced immunity.

31 Mar 2022

New project launched to explore how GI microbiota may contribute to neurodegeneration

Alzheimer's disease (AD) is a type of dementia that affects memory, thinking and behavior. According to the Alzheimer's Association, an estimated 6.2 million Americans are living with this progressive neurologic disorder, and it is the sixth-leading cause of death in the U.S.

31 Mar 2022

A bioinformatics approach for detecting SARS-CoV-2 co-infections

Researchers discuss a novel bioinformatics-based method for the detection of SARS-CoV-2 co-infections with the Delta and Omicron variants.

29 Mar 2022

Researchers report progress en route to developing a hypoallergenic cat

Researchers at InBio (formerly Indoor Biotechnologies), a biotech company in Virginia, report progress en route to developing a hypoallergenic cat – or at least treating patients with allergies to the domestic cat – in a new article published online in The CRISPR Journal.

29 Mar 2022

Impact of truncated open reading frame 8 protein variants of SARS-CoV-2

A new study identified unique truncated open reading frame 8 proteins among SARS-CoV-2 sequences.

25 Mar 2022

New SARS-CoV-2 Omicron-Delta recombinant virus identified in the US

Researchers reported a novel SARS-CoV-2 Omicron and Delta recombinant virus in the United States.

24 Mar 2022

Study uncovers a gene that strongly associates with breast cancer patient's treatment outcomes

A multidisciplinary team of researchers from Roswell Park Comprehensive Cancer Center and Kaiser Permanente Northern California have identified the first pharmacogenomic marker for anthracyclines and HER2-targeting drugs, two commonly used breast cancer chemotherapies.

23 Mar 2022

Researchers aim to study the underlying pathophysiology of diastolic heart failure

Of the estimated five million patients in the U.S. diagnosed with heart failure annually, nearly half will have heart failure with preserved ejection fraction (HFpEF). Also known as diastolic heart failure, HFpEF occurs when the heart's lower left chamber loses its ability to relax and fill up with enough blood in between in each heartbeat.

23 Mar 2022

Using a new data-driven approach to understand more about people with Type 1 diabetes

An interdisciplinary team of researchers from the University of Missouri, Children's Mercy Kansas City and Texas Children's Hospital has used a new data-driven approach to learn more about persons with Type 1 diabetes, who account for about 5-10% of all diabetes diagnoses.

21 Mar 2022

New computational approach creates spatial maps of single-cell data within tissues

A new computational approach developed by researchers at The University of Texas MD Anderson Cancer Center successfully combines data from parallel gene-expression profiling methods to create spatial maps of a given tissue at single-cell resolution.

21 Mar 2022

Bioinformatics News and Research

Further Reading

Novel targets for treating sorafenib-resistant hepatocellular carcinoma found using CRISPR-Cas9 screening

Report provides recommendations to help prevent or mitigate economic challenges during future public health emergencies

Wearables can identify changes in physiological systems during COVID-19 disease progression

Researchers investigate COVID-19 data with logistic regression model training

New bioinformatics platform predicts optimal treatment combinations for cancer patients

Certain antirheumatic drugs may lower incidence of Alzheimer's and related dementias in people with cardiovascular disease

Researchers develop universal AI algorithm to "clean" noisy single-cell RNA sequencing data

Researchers obtain a treasure trove of new data about RNA viruses from ocean water samples

Evidence SARS-CoV-2 undergoes ADAR-mediated A-to-I RNA editing in human cells

Groundbreaking collaborative work defines the risk of SARS-CoV-2 variants on immune protection

NIH program provides a real-time risk assessment of variants of SARS-CoV-2

New project launched to explore how GI microbiota may contribute to neurodegeneration

A bioinformatics approach for detecting SARS-CoV-2 co-infections

Researchers report progress en route to developing a hypoallergenic cat

Impact of truncated open reading frame 8 protein variants of SARS-CoV-2

New SARS-CoV-2 Omicron-Delta recombinant virus identified in the US

Study uncovers a gene that strongly associates with breast cancer patient's treatment outcomes

Researchers aim to study the underlying pathophysiology of diastolic heart failure

Using a new data-driven approach to understand more about people with Type 1 diabetes

New computational approach creates spatial maps of single-cell data within tissues

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