Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Gene editing shows promise for treating trisomy at cellular level

Gene editing techniques may eventually allow trisomy to be treated at the cellular level, according to an in vitro proof-of-concept study.

18 Feb 2025

Human-specific gene variant may hold key to evolution of language

The origins of human language remain mysterious. Are we the only animals truly capable of complex speech? Are Homo sapiens the only hominids who could give detailed directions to a far-off freshwater source or describe the nuanced purples and reds of a dramatic sunset?

18 Feb 2025

How does intermittent fasting affect β cell function and diabetes risk

Research shows short-term fasting improves glucose regulation, while long-term fasting in young mice impairs β cell function, potentially increasing T1D risk.

18 Feb 2025

Scientists pinpoint metabolic failure as the cause of muscle loss in aging

A multi-omics study reveals that impaired branched-chain amino acid (BCAA) catabolism is a key driver of sarcopenia, suggesting it as a potential therapeutic target.

17 Feb 2025

Stanford researchers identify key variants linked to inherited cancer risk

Thousands of single changes in the nucleotides that make up the human genome have been associated with an increased risk of developing cancer.

17 Feb 2025

Gene therapy shows promise in treating SCN1B-linked epileptic encephalopathies

Dravet syndrome and other developmental epileptic encephalopathies are rare but devastating conditions that cause a host of symptoms in children, including seizures, intellectual disability, and even sudden death.

14 Feb 2025

New discovery on mitochondrial protein could transform Charcot-Marie-Tooth treatment

Researchers from Cologne, Bochum, Padova and Angers have discovered a novel connection between mitochondrial function, protein quality control and cellular health, whose failure could be the leading cause in the currently incurable neurological disease Charcot-Marie-Tooth (CMT).

14 Feb 2025

Interferon pathway activation identified as key driver in OPLL pathogenesis

Ossification of the posterior longitudinal ligament (OPLL) is a progressive spinal disease characterized by ectopic bone formation in the spine, leading to severe neurological symptoms due to spinal cord compression. This condition is more prevalent in Asian countries and has been associated with various genetic and hormonal factors.

14 Feb 2025

Engineering safe and effective vaccinia virus vectors for next-generation vaccines

Announcing a new article publication for Zoonoses journal. Vaccinia virus (VACV) confers cross-protective immunity against the variola virus, the causative agent of smallpox, and has therefore been extensively exploited as a preventive vaccine. Despite the global eradication of smallpox in the 1980s, research efforts involving VACV have continued due to the potential threat of the variola virus being used as a bioweapon, which poses grave risks to human health.

14 Feb 2025

New insight into gut stem cell aging

A recent study led by Associate Professor Takuya Yamamoto and Researcher May Nakajima-Koyama has revealed that maintaining a delicate balance between interferon-gamma (IFN-γ) and extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signaling is essential for preserving the intestinal stem cell population during aging.

13 Feb 2025

New biomarker can accurately predict outcomes in meningiomas and breast cancers

Using a new technology and computational method, researchers from Fred Hutch Cancer Center and The University of Texas MD Anderson Cancer Center have uncovered a biomarker capable of accurately predicting outcomes in meningioma brain tumors and breast cancers.

13 Feb 2025

New atlas reveals aging’s impact on breast tissue and cancer risk

Aging is a privilege, but it also brings risks-including an increased likelihood of developing age-related diseases including cancer.

13 Feb 2025

Enzyme found in lymphatic cells enhances immune activity against tumors

When a tumor develops, it creates a structure around itself called the tumor stroma, within which blood and lymphatic vessels ensure nutritional and respiratory biological exchanges.

13 Feb 2025

Breakthrough discovery reveals key role of ovoid cells in object recognition memory

Take a look around your home and you'll find yourself surrounded by familiar comforts-photos of family and friends on the wall, well-worn sneakers by the door, a shelf adorned with travel mementos.

13 Feb 2025

Study identifies novel enhancers linked to neuropsychiatric disorders

Neuropsychiatric disorders are becoming increasingly prevalent. Given their complex and multifactorial pathogenesis, there is an urgent need for effective and targeted therapies that can improve patients' quality of life.

13 Feb 2025

Oral vancomycin induces PSC-IBD remission, driving gut microbiome and metabolic shifts

Findings indicate oral vancomycin induces remission in PSC-IBD, with notable microbiota changes and inflammation reduction, reversing after treatment ends.

13 Feb 2025

Study identifies vitamin E succinate as key to tumor growth control

High levels of fat mass and obesity-associated protein (FTO) have been linked to increased tumor growth and resistance to immunotherapy.

12 Feb 2025

Electrical activity drives aggression in small cell lung cancer

Researchers from the Francis Crick Institute have found that some particularly aggressive lung cancer cells can develop their own electric network, like that seen in the body's nervous system.

12 Feb 2025

UCLA study reveals key role of mismatch repair genes in Huntington’s disease

A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and triggering downstream pathologies and motor impairment, shedding light on disease mechanisms and potential new ways to develop therapies.

11 Feb 2025

Scientists discover functional role of introns in cells

Scientists have discovered that some tiny segments of RNA thought to be junk instead have a functional role in suppressing production of certain messenger RNAs and appear to help cells respond to oxidative stress.

11 Feb 2025