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Scientists map epigenetic changes across aging brain cells

Neurodegenerative diseases affect more than 57 million people globally. The incidence of these diseases, from Alzheimer's to Parkinson's to ALS and beyond, is expected to double every 20 years.

11 Mar 2026

The social and legal costs of ignoring AI diagnostics

Artificial intelligence (AI) is changing the field and practice of medicine, including legal liability and the perception of who is at fault when a patient experiences harm.

11 Mar 2026

New consensus defines oligometastatic stage in pancreatic cancer

Until now, the following has been true for metastatic pancreatic cancer: Once the tumor has spread, local treatment such as surgery is usually no longer an option.

10 Mar 2026

New review calls for biologically grounded approach to psychiatric diagnosis

A comprehensive invited review published today in Brain Medicine confronts one of the most persistent paradoxes in modern medicine: psychiatry remains the only major clinical discipline that diagnoses complex illness primarily through conversation and symptom checklists, while fields such as oncology and cardiology long ago embraced laboratory markers, imaging, and molecular profiling.

10 Mar 2026

New catalog identifies dozens of plasma membrane repair proteins

In the evolutionary history of life, the ability of a cell to separate its inner world from the external environment was an important turning point.

10 Mar 2026

Study links p-tau217 levels to long-term dementia risk in women

Researchers from the University of California San Diego have found that a novel blood-based biomarker can predict a woman's risk of developing dementia as many as 25 years before symptoms appear.

10 Mar 2026

Cellular energy changes may help detect early-stage major depression

Researchers may have discovered a new way to diagnose and treat major depression at the earliest stage of the condition, giving patients the best opportunity for recovery.

10 Mar 2026

Mapping the evolution of AI in organelle segmentation

In organelle imaging, segmentation aims to accurately delineate pixels or voxels corresponding to target organelles from background, noise, and other cellular structures in microscopy images, thereby generating masks suitable for quantitative analysis. Robust segmentation is foundational to downstream quantification, including morphological characterization, spatial distribution analysis, temporal trajectory tracking, and the detection of key biological events.

10 Mar 2026

Using engineered bacteria to breach tumor defenses

Baylor University researchers have published a novel approach to fight colorectal cancer, using modified bacteria as a courier to deliver potent cancer-killing proteins into tumor cells. Michael S. VanNieuwenhze, Ph.D., FRSC, University Distinguished Professor and chair of the Department of Biology, along with Baylor doctoral students and a colleague at Texas Tech University Health Sciences Center, published their promising research in Cell Chemical Biology.

10 Mar 2026

Brain connectivity differences found in infants with congenital heart disease

The prevalence of congenital heart disease points to the need for a better understanding of how it influences neurodevelopment. New in JNeurosci, Jung-Hoon Kim and Catherine Limperopoulos, from Children's National Hospital, led a study examining brain network disruptions that may be linked to congenital heart disease.

9 Mar 2026

Exercise triggers memory-related brain waves in the hippocampus

A single session of physical exercise can spawn a boost of neural activity in brain networks that underlie learning and memory, according to a new study led by the University of Iowa.

9 Mar 2026

AI model flags hidden breast cancers years before diagnosis in routine mammograms

Researchers evaluated four deep learning models using over 112,000 negative screening mammograms from the UK NHS to determine how well artificial intelligence could predict future breast cancers missed during routine screening. The MIT-developed Mirai model performed best, identifying about 27.5% of interval cancers within the top 4% of women flagged as highest risk.

9 Mar 2026

Preventing postoperative rebleeding in intracerebral hemorrhage surgery

Intracerebral hemorrhage (ICH) is the stroke subtype with the highest mortality and disability rates, and early hematoma evacuation is crucial for improving prognosis.

9 Mar 2026

Women face higher liver fibrosis risk from cardiometabolic factors than men

Women with certain cardiometabolic risk factors, including type 2 diabetes and high waist circumference, face a greater increase in risk for liver fibrosis than men with the same risk factors.

9 Mar 2026

Cellular roadmap offers new targets for improving rotator cuff surgical repair

Rotator cuff tears are among the most common and debilitating musculoskeletal injuries, frequently causing chronic pain, reduced shoulder mobility, and a high risk of re-injury even after surgical repair.

9 Mar 2026

Brain network predicts how quickly we adapt to social behavior

Humans often adapt their behavior to that of other people with lightning speed. A new study by the University of Zurich reveals what brain networks govern social mentalization and adaptation, making it possible to predict how flexibly one person reacts to others.

9 Mar 2026

FOXJ3 gene identified as the critical link between abnormal brain development and epilepsy

Researchers have discovered that mutations in the FOXJ3 gene act as a "master switch" failure, disrupting how the brain builds its layers and leading to FCD, a primary cause of drug-resistant epilepsy.

9 Mar 2026

Understanding PIEZO2 mutations and sensory disorders

Every time we feel a gentle tap on the skin, specialized nerve cells convert that physical force into an electrical signal that the brain can interpret as touch. While scientists have long known that a protein called PIEZO2 acts as a key sensor for touch, it remained unclear why PIEZO2 is specialized for the localized mechanical forces experienced by sensory neurons, whereas its close relative PIEZO1 responds to broader mechanical stresses such as those generated when cells stretch, as occurs in blood vessels.

9 Mar 2026

Can one AI analyze all medical scans? MedVersa shows promise across multiple imaging tasks

esearchers developed MedVersa, a generalist multimodal AI model trained on tens of millions of medical imaging instances to perform diverse radiology tasks within a single framework. The model matched or exceeded specialist AI systems across several benchmarks and produced radiology reports comparable to human reports in many cases while improving reporting efficiency.

8 Mar 2026

Case report describes treatment of rare calcified solid pseudopapillary pancreatic tumor

A new case report was published in Volume 13 of Oncoscienceon February 7, 2026, titled "Massive calcified solid pseudopapillary neoplasm of the pancreatic head."

6 Mar 2026