Membrane News and Research

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Drug shows new promise in treating breast cancer with brain metastases or recurrent glioblastoma

A drug effective in treating breast cancer shows new promise in addressing breast cancer with brain metastases or recurrent glioblastoma, as reported by results of a prospective window-of-opportunity trial at the University of Texas Health Science Center at San Antonio (UT Health San Antonio).

8 Aug 2024

Breakthrough discovery could boost stem-cell transplants by improving cell mobilization

A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body's different blood cells.

8 Aug 2024

ProDOL revolutionizes protein quantification in living cells

Scientists have developed a new way of counting labeled proteins in living cells that could become a standard and valuable tool in the field of biomedical research.

8 Aug 2024

Cordyceps sinensis shows promise in treating sepsis-associated acute kidney injury

Announcing a new publication for Acta Materia Medica journal. Cordyceps sinensis (CS) has been widely used as a dietary supplement or traditional medicine for the prevention, treatment, and prognostication of various diseases, because of its pleiotropic pharmacological properties.

7 Aug 2024

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

In this interview conducted at Pittcon 2024, we spoke to Professor John Yates about capturing cardiomyocyte cell-to-cell heterogeneity via shotgun top-down proteomics.

From Pittcon 6 Aug 2024

Cholesterol imbalance linked to neurodegeneration, study suggests potential strategies for intervention

Research highlights how cholesterol imbalances in the brain contribute to neurodegenerative diseases like Alzheimer's, Huntington's, and Parkinson's, suggesting targeted therapeutic interventions.

5 Aug 2024

Novel antibiotic compound shows promise against drug-resistant bacteria and flesh-eating infections

Researchers at Washington University School of Medicine in St. Louis have developed a novel compound that effectively clears bacterial infections in mice, including those that can result in rare but potentially fatal "flesh-eating" illnesses.

2 Aug 2024

New optical neural chip technology reveals unexpected dopamine dynamics

DGIST (President Lee Kunwoo) Department of Brain Sciences Professor Lee Kwang and his team have discovered a new correlation between neural signaling in the brain and dopamine signaling in the striatum.

2 Aug 2024

Study provides novel insights into the molecular mechanisms of melanoma progression

Cong Peng et al., at Department of Dermatology, Xiangya Hospital, Central South University, China, conducted a study titled "NETO2 promotes melanoma progression via activation of the Ca²⁺/CaMKII signaling pathway" that investigates the role of Neuropilin and tolloid-like 2 (NETO2) in melanoma, a deadly form of skin cancer.

2 Aug 2024

Groundbreaking method dmSLAY improves antimicrobial peptide effectiveness and safety

Researchers developed a high-throughput method, dmSLAY, to assess thousands of AMP variants, combining it with machine learning to enhance membrane selectivity and reduce toxicity.

1 Aug 2024

Study elucidates mechanisms behind G protein selectivity and efficacy in adenosine A2A receptor

In a groundbreaking study, a multinational research team led by Dr. Adnan Sljoka (RIKEN) and Prof. Akio Kitao (Tokyo Tech), in collaboration with Prof. Scott Prosser (University of Toronto), has carried out experimental and computational studies to elucidate the mechanisms behind G protein selectivity and efficacy in the human adenosine A2A receptor (A2AR).

1 Aug 2024

Novel electrical impedance technique enhances drug testing for cardiac safety

When developing new drugs, understanding their effects on ion channels in the body, such as the human ether-a-go-go-related gene (hERG) ion channel found in neurons and heart muscle cells, is critical.

1 Aug 2024

Novel anti-tuberculosis compound targets bacterial membrane protein

Researchers from Heinrich Heine University Düsseldorf (HHU) and the University of Duisburg-Essen (UDE) have together succeeded in identifying and synthesizing a group of molecules that can act against the cause of tuberculosis in a new way. In the scientific journal Cell Chemical Biology, they describe that the so-called callyaerins act against the infectious disease by employing a fundamentally different mechanism compared to antibiotic agents used to date.

1 Aug 2024

Membrane News and Research

Drug shows new promise in treating breast cancer with brain metastases or recurrent glioblastoma

Breakthrough discovery could boost stem-cell transplants by improving cell mobilization

ProDOL revolutionizes protein quantification in living cells

Cordyceps sinensis shows promise in treating sepsis-associated acute kidney injury

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

Cholesterol imbalance linked to neurodegeneration, study suggests potential strategies for intervention

Novel antibiotic compound shows promise against drug-resistant bacteria and flesh-eating infections

New optical neural chip technology reveals unexpected dopamine dynamics

Study provides novel insights into the molecular mechanisms of melanoma progression

Groundbreaking method dmSLAY improves antimicrobial peptide effectiveness and safety

Study elucidates mechanisms behind G protein selectivity and efficacy in adenosine A2A receptor

Novel electrical impedance technique enhances drug testing for cardiac safety

Novel anti-tuberculosis compound targets bacterial membrane protein

AI unlocks potential of antimicrobial peptides for new antibiotics

Powerful visualization technologies offer new insight into understanding muscle contraction in humans

Commonly used anesthetic drug can restore the function of ion channel linked to epilepsy

Propofol shows potential for treating epilepsy and neurological disorders

2024 is shaping up to be “the year of iPSCs"

Xanthones show promise in diabetes with antioxidant and anti-inflammatory properties

Understanding iron overload in β-thalassemia: Mechanisms, diagnosis, and treatments

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