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UCLA announces participation in a phase 3 trial evaluating tecovirimat for the treatment of monkeypox

The UCLA Clinical AIDS Research and Education (CARE) Center today announced its participation in STOMP (Study of Tecovirimat for Human Monkeypox Virus), or A5418, a phase 3, randomized, placebo-controlled, double-blind trial evaluating the safety and efficacy of tecovirimat for the treatment of human monkeypox.

16 Sep 2022

Antibody drugs are not recommended for patients with covid-19, say WHO experts

The antibody drugs sotrovimab and casirivimab-imdevimab are not recommended for patients with covid-19, says a WHO Guideline Development Group of international experts in The BMJ today.

16 Sep 2022

JGU researchers seek to gain a better understanding of depression

Human beings and fruit flies have very little in common - at first sight. However, studying these flies it is in fact possible to find out more about human nature, particularly when it comes to depressive disorders.

16 Sep 2022

Engineers create a small, non-invasive device that measures changes in tumor size

Engineers at the Georgia Institute of Technology and Stanford University have created a small, autonomous device with a stretchable/flexible sensor that can be adhered to the skin to measure the changing size of tumors below.

16 Sep 2022

U of M researchers receive grant to map senescent cells in preclinical studies and human tissues

Researchers at the University of Minnesota Medical School and the Institute on the Biology of Aging and Metabolism were awarded a total of $19.3 million in grants from the National Institutes of Health Common Fund to map senescent cells in preclinical studies and human tissues as part of the SenNet Consortium.

16 Sep 2022

New abortion laws jeopardize cancer treatment for pregnant patients

As abortion bans go into effect across a contiguous swath of the South, cancer physicians are wrestling with how new state laws will influence their discussions with pregnant patients about what treatment options they can offer.

16 Sep 2022

Higher levels of microbiota engraftment linked to greater chances of transplantation success

From incurable intestinal infections to metabolic syndrome, from melanoma, to chronic inflammatory bowel disease, such as irritable bowel syndrome, to Tourette's syndrome: many diseases can potentially be cured by Fecal Microbiota Transplantation (FMT), and researchers from the Catholic University, Rome and the University of Trento have shown that the greater the level of engraftment of the transplanted microorganisms, the greater the chances of success of the therapy.

15 Sep 2022

Scientists develop and test a new model of traumatic brain injury in zebrafish

A group of scientists, which included researchers from the Ural Federal University (UrFU), have developed and successfully tested a new model of traumatic brain injury (TBI) in zebrafish.

15 Sep 2022

Court ruling may spur competitive health plans to bring back copays for preventive services

Tom and Mary Jo York are a health-conscious couple, going in for annual physicals and periodic colorectal cancer screening tests. Mary Jo, whose mother and aunts had breast cancer, also gets regular mammography tests.

15 Sep 2022

Exercise hormone irisin blocks Parkinson's-associated α-synuclein aggregation and related neuronal toxicity

A new paper discusses the hope held out by recent results on a compound called irisin, a short protein secreted by skeletal muscle that produces some exercise-related effects on the brain.

15 Sep 2022

Combined oral contraceptives associated with elevated risk of venous thromboembolism in obese women

Obese women who use oral contraceptives containing estrogen and progestin have a 24-fold increased risk of venous thromboembolism (VTE) compared with non-obese women not using the drugs, according to a review paper published today in ESC Heart Failure, a journal of the European Society of Cardiology (ESC).

14 Sep 2022

Tufts researchers use machine learning to identify new drug cocktails against tuberculosis

Imagine you have 20 new compounds that have shown some effectiveness in treating a disease like tuberculosis (TB), which affects 10 million people worldwide and kills 1.5 million each year.

14 Sep 2022

Microneedle technology for low-cost, painless, and bloodless tattoos

Instead of sitting in a tattoo chair for hours enduring painful punctures, imagine getting tattooed by a skin patch containing microscopic needles.

14 Sep 2022

STRATAGEM aims to provide new perspectives on multidrug-resistant solid tumors

Achieving a good efficacy of chemotherapy is one of the major challenges still unresolved in oncological patients. The main limitation to the efficacy of chemotherapy is the multidrug-resistant (MDR) phenotype, a multiple cross-resistance towards different anticancer drugs.

14 Sep 2022

What is the impact of COVID-19 treatments targeting intracellular Neu1?

In a new study, researchers assessed the impact of targeting intracellular Neu1 on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

14 Sep 2022

California and New York aim to curb diet pill sales to minors

California and New York are on the cusp of going further than the FDA in restricting the sale of non-prescription diet pills to minors as pediatricians and public health advocates try to protect kids from extreme weight-loss gimmicks online.

14 Sep 2022

Study estimates the cost-effectiveness of therapeutic alternatives

Giving standard chemotherapy drugs in a specific sequence for some types of metastatic breast cancer can help reduce overall costs and improve the value of care while preserving quality of life, according to a study led by UNC Lineberger Comprehensive Cancer Center and UNC Gillings School of Global Public Health researchers.

14 Sep 2022

SARS-CoV-2 viral infection is associated with an increased risk of Alzheimer’s disease

Older people who were infected with COVID-19 show a substantially higher risk - as much as 50% to 80% higher than a control group - of developing Alzheimer's disease within a year, according to a study of more than 6 million patients 65 and older.

14 Sep 2022

Signal transduction via the EGFR pathway likely to be involved in lenvatinib resistance

The multitargeted tyrosine kinase inhibitor (MKI), lenvatinib, is widely used to treat advanced and metastatic thyroid cancer. However, the molecular mechanisms by which thyroid cancer cells become resistant to lenvatinib remain poorly understood. In this study, we demonstrated, for the first time, that activation of the epidermal growth factor receptor (EGFR)-mediated signaling pathway is involved in lenvatinib resistance in thyroid cancer cells.

14 Sep 2022

Efficacy and safety of monoclonal antibodies against SARS-CoV-2 during pregnancy

In an article published in the journal Expert Opinion on Drug Safety, scientists have described the safety and efficacy profiles of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) monoclonal antibodies in pregnant women with coronavirus disease 2019 (COVID-19).

13 Sep 2022

Drugs News and Research

UCLA announces participation in a phase 3 trial evaluating tecovirimat for the treatment of monkeypox

Antibody drugs are not recommended for patients with covid-19, say WHO experts

JGU researchers seek to gain a better understanding of depression

Engineers create a small, non-invasive device that measures changes in tumor size

U of M researchers receive grant to map senescent cells in preclinical studies and human tissues

New abortion laws jeopardize cancer treatment for pregnant patients

Higher levels of microbiota engraftment linked to greater chances of transplantation success

Scientists develop and test a new model of traumatic brain injury in zebrafish

Court ruling may spur competitive health plans to bring back copays for preventive services

Exercise hormone irisin blocks Parkinson's-associated α-synuclein aggregation and related neuronal toxicity

Combined oral contraceptives associated with elevated risk of venous thromboembolism in obese women

Tufts researchers use machine learning to identify new drug cocktails against tuberculosis

Microneedle technology for low-cost, painless, and bloodless tattoos

STRATAGEM aims to provide new perspectives on multidrug-resistant solid tumors

What is the impact of COVID-19 treatments targeting intracellular Neu1?

California and New York aim to curb diet pill sales to minors

Study estimates the cost-effectiveness of therapeutic alternatives

SARS-CoV-2 viral infection is associated with an increased risk of Alzheimer’s disease

Signal transduction via the EGFR pathway likely to be involved in lenvatinib resistance

Efficacy and safety of monoclonal antibodies against SARS-CoV-2 during pregnancy

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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