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Research characterizes iPS87 cell line as cancer-inducing, stem cell-like cell line

Oncotarget Volume 11, Issue 12 reported outside its natural niche, the cultured prostate cancer stem cells lost their tumor-inducing capability and stem cell marker expression after approximately 8 transfers at a 1:3 split ratio.

27 Mar 2020

Size of tumor tissue area crucial for reliable cancer prognosis, study shows

The method of choice used for preparing tissue samples can lead to biased results in the analysis of cancer patient survival.

27 Mar 2020

New approach shows promise as a treatment for chemo-resistant ovarian cancer

Researchers have made a discovery about the behavior of ovarian cancer cells that could lead to a new treatment approach.

27 Mar 2020

A promising strategy to overcome drug resistance developed by blood cancer cells

In a collaborative study published in Blood Advances, a research group led by Beate Heissig at Juntendo University and Yousef Salama at An Najah University report a strategy to overcome drug resistance developed by blood cancer cells.

27 Mar 2020

Targeting specific histone deacetylase may be novel therapeutic strategy for NSCLC

The survival rates for patients with non-small cell lung cancer have improved greatly over the past decade thanks to several new targeted treatment options for patients.

26 Mar 2020

Highly focused radiation may slow disease progression in men with oligometastatic prostate cancer

Highly focused, intense doses of radiation called stereotactic ablative radiation (SABR) may slow progression of disease in a subset of men with hormone-sensitive prostate cancers that have spread to a few separate sites in the body, according to results of a phase II clinical trial of the therapy.

26 Mar 2020

New type of immunotherapy shows promise for future treatment of ovarian cancer

Malignant ovarian cancer is insidious: Known and feared for vague and uncharacteristic symptoms that often mean the disease is discovered so late that on average only four out of six patients are still alive after five years.

26 Mar 2020

Insights into diagnosis and treatment of rare pediatric brain cancer

Ependymoma is a rare form of brain cancer that implicates children and is often tricky to diagnose.

26 Mar 2020

Intense and targeted radiotherapy could slow progression of certain prostate cancers

Targeted and strong doses of stereotactic ablative radiation (SABR) radiotherapy could slow progression in prostate cancer.

26 Mar 2020

Why Primary Cells Are Important for In Vitro ADME-Tox Studies

Lonza is a large, multinational corporation serving the entire pharmaceutical product development and manufacturing pipeline, from non-clinical research products to final dosage and delivery solutions.

From Lonza 26 Mar 2020

Despite failures, chemotherapy still promising against fatal pediatric brain cancer

The pediatric brain cancer known as diffuse intrinsic pontine glioma is almost uniformly fatal. In part, this is due to where and how it grows, forming as a diffuse net of cells in a part of the brainstem called the pons, which controls essential functions like breathing and swallowing.

25 Mar 2020

Advancing CAR T-cell therapy for treatment of solid tumors

The full title of the research is "The study of the mechanisms of effectiveness of T-cells CAR-T towards solid tumors"; it was supported by nonprofit RakFond (Cancer Fund) and CyStoreLab (a resident of Skolkovo).

25 Mar 2020

Overexpression of hPCL3S could contribute to tumor progression in prostate cancer

The cover for issue 12 of Oncotarget features Figure 11, "Global analyses of the RNA-Seq data of LNCaP empty vector and LNCaP cells overexpressing hPCL3S (Clone 12)" by Abdelfettah, et al.

25 Mar 2020

A genetic toolkit to produce multifunctional magnetic nanoparticles

Magnetic bacteria might soon be used for the production of novel biomaterials. A team of microbiologists at the University of Bayreuth led by Prof. Dr. Dirk Schüler developed a modular system for the genetic reprogramming of bacteria, thereby turning the organisms into cell factories for multifunctional magnetic nanoparticles that combine various useful functions and properties.

25 Mar 2020

Combination produces more proliferative, enduring central memory T cells for cellular therapy

Treating T cells harvested from a patient with a combination of an epigenetic drug and a cytokine while expanding the cells in the lab re-programs them into a stronger T cell type that persists longer than its comrades, researchers at The University of Texas MD Anderson Cancer Center report in Cancer Immunology Research, a journal of the American Association for Cancer Research.

25 Mar 2020

Cancer could potentially be treated with new immunotherapy approach, say researchers

Researchers have made a discovery about EGR4 that could instigate a new immunotherapy approach to treating cancer.

25 Mar 2020

Researchers investigate how cellular protein shredders can be programmed to fight cancer

An international team of researchers led by the Universities of Bonn and Ulm has investigated how a cell's own "protein shredder" can be specifically programmed to fight cancer.

25 Mar 2020

Study identifies brake on immune activity raising new possibilities for anticancer therapy

The immune system is like a carefully regulated machine, complete with its own built-in "brakes" that prevent it from overreacting and causing excess inflammation in otherwise healthy tissues.

25 Mar 2020

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

Joint research between Kobe University and National Hospital Organization Kyushu Cancer Center has revealed that mice with mutations in the YAP signal pathway develop head-and-neck cancer over an extremely short period of time (world's fastest cancer onset mouse model), indicating that this pathway plays a crucial role in the onset of these cancers.

25 Mar 2020

Supercomputer helps benchmark new molecular docking tool

With the American Cancer Society estimating 1.76 million new cases and more than 600,000 deaths during 2019 in the U.S. alone, cancer remains a critical healthcare challenge.

25 Mar 2020

Tumor News and Research

Research characterizes iPS87 cell line as cancer-inducing, stem cell-like cell line

Size of tumor tissue area crucial for reliable cancer prognosis, study shows

New approach shows promise as a treatment for chemo-resistant ovarian cancer

A promising strategy to overcome drug resistance developed by blood cancer cells

Targeting specific histone deacetylase may be novel therapeutic strategy for NSCLC

Highly focused radiation may slow disease progression in men with oligometastatic prostate cancer

New type of immunotherapy shows promise for future treatment of ovarian cancer

Insights into diagnosis and treatment of rare pediatric brain cancer

Intense and targeted radiotherapy could slow progression of certain prostate cancers

Why Primary Cells Are Important for In Vitro ADME-Tox Studies

Despite failures, chemotherapy still promising against fatal pediatric brain cancer

Advancing CAR T-cell therapy for treatment of solid tumors

Overexpression of hPCL3S could contribute to tumor progression in prostate cancer

A genetic toolkit to produce multifunctional magnetic nanoparticles

Combination produces more proliferative, enduring central memory T cells for cellular therapy

Cancer could potentially be treated with new immunotherapy approach, say researchers

Researchers investigate how cellular protein shredders can be programmed to fight cancer

Study identifies brake on immune activity raising new possibilities for anticancer therapy

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

Supercomputer helps benchmark new molecular docking tool

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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