Clinical Trial News and Research

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Aeras announces publication of Phase 2 results of two TB vaccines

Aeras, a nonprofit organization dedicated to developing vaccines against tuberculosis (TB), today announced the publication of the full results from a Phase 2, randomized, controlled clinical trial of two TB vaccines-- the currently available BCG vaccine and an investigational vaccine, H4:IC31--in the New England Journal of Medicine (NEJM).

12 Jul 2018

Captozyme begins cross-over study of Nephure oxalate reducing enzyme

Captozyme, Inc. announced today that it is initiating a prospective double-blind, randomized, placebo controlled, cross-over study, with Nephure, an oxalate reducing enzyme, to determine the extent to which Nephure vs. placebo reduces urinary oxalate excretion (mg/24 hour) in healthy subjects who are provided a controlled diet.

12 Jul 2018

Clinical trial examines impact of high-dose omega-3 and vitamin D on halting type 1 diabetes

Scientists from the Diabetes Research Institute at the University of Miami Miller School of Medicine today announced the launch of a new clinical trial that will assess the impact of high-dose omega-3 fatty acids and vitamin D supplementation on halting the progression of type 1 diabetes.

12 Jul 2018

New clinical trial to evaluate virotherapy and immunotherapy combination for ovarian, colorectal cancers

Ludwig Cancer Research and the Cancer Research Institute announce the initiation of a clinical trial to evaluate the combination of ONCOS-102, an experimental anti-tumor virotherapy, with the checkpoint blockade antibody IMFINZI (durvalumab) for advanced ovarian and colorectal cancers.

12 Jul 2018

Study: Hepatitis C vaccine could drastically reduce transmission among injecting drug users

Among the most serious consequences of the opioid epidemic is the spread of hepatitis C among injecting drug users.

12 Jul 2018

Researchers elucidate role of mutations in deadly brain cancer

Researchers from the University of North Carolina Lineberger Comprehensive Cancer Center have discovered how different mutations in a specific gene help drive glioblastoma, the most lethal form of brain cancer.

11 Jul 2018

Clinical trial results of tucatinib with T-DM1 shows promise in treating HER2+ breast cancer

Phase 1b clinical trial results published in JAMA Oncology show promise for the combination of tucatinib with T-DM1 against heavily pretreated HER2-positive breast cancer.

11 Jul 2018

Researchers develop biofilm formulations that protect from necrotizing enterocolitis

Most of the time, we think biofilms are bad news. And when pathogenic microbes form biofilms, they are.

11 Jul 2018

Inhibiting immune-regulating molecule could prevent or reverse renal injury, research shows

Special cells called podocytes aid the kidneys as they clean the blood and balance the body's fluid levels. Podocytes filter blood as it passes through the cells' foot-like projections they are named for, interwoven like the fingers of clasped hands.

11 Jul 2018

Study: Eating Mediterranean-type diet could reduce bone loss in osteoporosis patients

Eating a Mediterranean-type diet could reduce bone loss in people with osteoporosis - according to new research from the University of East Anglia.

11 Jul 2018

Altitude sickness drug may offer significant gains for patients with glioblastoma

A drug used to treat altitude sickness -- as well as glaucoma, epilepsy, heart failure and seizures -- may also offer significant gains for patients with a fast-growing brain tumor known as glioblastoma, according to a study published July 4, 2018, in the journal Science Translational Medicine.

10 Jul 2018

UC San Diego Health now offers new treatment option for men with enlarged prostate

Physicians at UC San Diego Health are now offering prostate artery embolization as a new treatment option for men with benign prostatic hyperplasia, or an enlarged prostate.

10 Jul 2018

Human trial identifies common blood pressure medication as safe, effective therapy for diabetes

Researchers at the University of Alabama at Birmingham Comprehensive Diabetes Center have discovered a safe and effective novel therapy to reduce insulin requirements and hypoglycemic episodes in adult subjects with recent onset Type 1 diabetes by promoting the patient's own beta cell function and insulin production -- the first such discovery to target diabetes in this manner.

9 Jul 2018

HPV test better than Pap when screening for cervical cancer

The Pap smear test has been used widely for the past five decades to understand and screen for early signs of cervical cancer. The conventional test has been largely replaced by a liquid-based Pap cytology test. Soon it may be replaced by another test – the Human papilloma virus test or the HPV test finds new research.

4 Jul 2018

Antioxidants do not improve sperm quality

Researchers have found that despite studies that claim that antioxidants are good for sperm production, a new study has shown that there is no such benefit.

4 Jul 2018

Viral immunotherapy shows promise to treat pediatric brain tumors

A viral immunotherapy using a herpes virus to treat brain tumors has been shown to be safe and well-tolerated in a pediatric study from the University of Alabama at Birmingham and Children's of Alabama.

4 Jul 2018

New algorithm predicts patients who will benefit from high blood pressure treatment

Using data from large clinical trials, UT Southwestern researchers developed a way to predict which patients will benefit most from aggressive high blood pressure treatment.

3 Jul 2018

Antioxidants do not improve sperm quality in infertile men, finds study

A large clinical trial has shown that daily antioxidant supplementation among men with infertility does not make a difference to the quality of their sperm.

2 Jul 2018

PMDA approves use of LYNPARZA in patients with BRCA-mutated breast cancer

AstraZeneca and Merck, known as MSD outside the United States and Canada, today announced that Japan's Pharmaceuticals and Medical Devices Agency has approved LYNPARZA tablets for use in patients with unresectable or recurrent BRCA-mutated, human epidermal growth factor receptor 2 -negative breast cancer who have received prior chemotherapy.

2 Jul 2018

Streamlining and translating basic science discoveries into the clinic

To make sure that good ideas to enhance healthcare are not lost due to a lack of resources, a growing number of centers at Penn Medicine organize forums to pitch ideas to improve medical devices and technology, hold annual competitions to fund studies to improve patient care while keeping costs down, and sponsor seed grants for programs focused on patients who need individualized tailoring of their treatment.

2 Jul 2018

Clinical Trial News and Research

Aeras announces publication of Phase 2 results of two TB vaccines

Captozyme begins cross-over study of Nephure oxalate reducing enzyme

Clinical trial examines impact of high-dose omega-3 and vitamin D on halting type 1 diabetes

New clinical trial to evaluate virotherapy and immunotherapy combination for ovarian, colorectal cancers

Study: Hepatitis C vaccine could drastically reduce transmission among injecting drug users

Researchers elucidate role of mutations in deadly brain cancer

Clinical trial results of tucatinib with T-DM1 shows promise in treating HER2+ breast cancer

Researchers develop biofilm formulations that protect from necrotizing enterocolitis

Inhibiting immune-regulating molecule could prevent or reverse renal injury, research shows

Study: Eating Mediterranean-type diet could reduce bone loss in osteoporosis patients

Altitude sickness drug may offer significant gains for patients with glioblastoma

UC San Diego Health now offers new treatment option for men with enlarged prostate

Human trial identifies common blood pressure medication as safe, effective therapy for diabetes

HPV test better than Pap when screening for cervical cancer

Antioxidants do not improve sperm quality

Viral immunotherapy shows promise to treat pediatric brain tumors

New algorithm predicts patients who will benefit from high blood pressure treatment

Antioxidants do not improve sperm quality in infertile men, finds study

PMDA approves use of LYNPARZA in patients with BRCA-mutated breast cancer

Streamlining and translating basic science discoveries into the clinic

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