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Pfizer terminates clinical studies evaluating domagrozumab for treatment of Duchenne muscular dystrophy

Pfizer Inc. announced today that it is terminating two ongoing clinical studies evaluating domagrozumab (PF-06252616) for the treatment of Duchenne muscular dystrophy (DMD): a Phase 2 safety and efficacy study (B5161002) and an open-label extension study (B5161004).

30 Aug 2018

Celmatix and Ferring announce genomics collaboration aimed at uncovering new insights into ovarian biology

Ferring Pharmaceuticals and Celmatix today announced an ambitious genomics collaboration aimed at uncovering new insights into ovarian biology and accelerating the development of personalized interventions in reproductive medicine and women's health.

30 Aug 2018

Vertex, Genomics team up to improve discovery of precision medicines

Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) and Genomics plc today announced a three-year collaboration, extendable to five years, to use human genetics and machine learning to improve discovery of targets for precision medicines, and to advance understanding of the clinical impact of human genetic variation and patient stratification in diseases with significant unmet need.

30 Aug 2018

$Genetics study uncovers key factors for fracture risk in osteoporosis$

Genetics study uncovers key factors for fracture risk in osteoporosis

The largest study ever to investigate the genetics of osteoporosis and fracture risk determined that only two examined factors - bone mineral density and muscle strength - play a potentially causal role in the risk of suffering osteoporotic fracture, a major health problem affecting more than 9 million people worldwide very year.

30 Aug 2018

Scientists explore DNA replication errors that can lead to cancer

Scientists at Hollings Cancer Center at the Medical University of South Carolina have found that some cells can divide without a molecule that was previously thought necessary.

30 Aug 2018

$Genome-wide association study provides insight into biologic mechanisms leading to fractures$

Genome-wide association study provides insight into biologic mechanisms leading to fractures

A paper titled "Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomization study" appeared today in the British Medical Journal.

30 Aug 2018

Study yields therapeutic clues to combat drug resistance in rare aggressive cancer

Stephen Elledge, PhD, and his team did not set out to find therapies that could render tumors less resistant to therapy or make existing drugs more potent against a rare form of cancer. But these are precisely the clinical insights that their most recent study has yielded.

29 Aug 2018

Using novel gene therapy to cure infants born with severe combined immunodeficiency

Out of every 60,000 births, a baby arrives to face the world without a fully functioning immune system leaving them unequipped to fight even the most common infections.

29 Aug 2018

Researchers discover reason why many bladder cancer patients do not respond to immunotherapy

Mount Sinai researchers have discovered that a particular type of cell present in bladder cancer may be the reason why so many patients do not respond to the groundbreaking class of drugs known as PD-1 and PD-L1 immune checkpoint inhibitors, which enable the immune system to attack tumors.

29 Aug 2018

British Heart Foundation launches unique £30 million global cardiovascular challenge

The British Heart Foundation is today launching the Big Beat Challenge, a unique research funding award that will bring together world-leading researchers and innovators to identify and solve any of the biggest problems in heart and circulatory disease.

29 Aug 2018

Researchers enlist genes that control production of cellular energy stored in ATP molecules

Everything the body does--your brain thinking, your heart beating, your cells growing--requires energy. Consequently, it comes as no surprise that disruptions in energy production can contribute to a wide range of diseases.

29 Aug 2018

Researchers report how Zika proteins hijack host cells

Most people infected with Zika never show symptoms. But the virus sometimes causes severe disability -- from microcephaly in babies to weakness or partial paralysis in adults -- and there is no treatment.

28 Aug 2018

Researchers develop 3D map of the human genome

Researchers have developed a way of mapping the positions of genes within cells to understand more about how the genome is organized.

28 Aug 2018

NRGene constructs comprehensive soy genome diversity-haplotype database

NRGene, the leading genomic big data company, has constructed a comprehensive soy genome diversity-haplotype database based on results from GenoMAGIC™, allowing commercial and academic researchers never-before-available insights into the genomic diversity within the soybean crop.

28 Aug 2018

Study reveals how gene variant affects chronic pain outcomes after trauma

The gene FKBP5 is a critical regulator of the stress response and affects how we respond to environmental stimuli. Previous studies have shown that certain variants of this gene play a role in the development of neuropsychiatric disorders such as posttraumatic stress disorder, depression, suicide risk, and aggressive behavior.

28 Aug 2018

Genome News and Research

Pfizer terminates clinical studies evaluating domagrozumab for treatment of Duchenne muscular dystrophy

Celmatix and Ferring announce genomics collaboration aimed at uncovering new insights into ovarian biology

Vertex, Genomics team up to improve discovery of precision medicines

Genetics study uncovers key factors for fracture risk in osteoporosis

Scientists explore DNA replication errors that can lead to cancer

Genome-wide association study provides insight into biologic mechanisms leading to fractures

Study yields therapeutic clues to combat drug resistance in rare aggressive cancer

Using novel gene therapy to cure infants born with severe combined immunodeficiency

Researchers discover reason why many bladder cancer patients do not respond to immunotherapy

British Heart Foundation launches unique £30 million global cardiovascular challenge

Researchers enlist genes that control production of cellular energy stored in ATP molecules

Researchers report how Zika proteins hijack host cells

Researchers develop 3D map of the human genome

NRGene constructs comprehensive soy genome diversity-haplotype database

Study reveals how gene variant affects chronic pain outcomes after trauma

New radiomic signature offers predictive score for efficacy of immunotherapy in patients

Changes in TRPV3 genes may have helped mammoths withstand lower temperatures

Comprehensive analysis reveals weaknesses to target in common pediatric solid tumor

Medical or surgical treatment for severe heartburn prevents esophageal cancer

Sleep loss can confer increased risk of adverse weight gain, shows study

The art of CRISPR: The power and promise of gene editing eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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