Clinical Trial News and Research

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Study using i2b2 could help standardize artificial coma treatment for RSE patients

Status epilepticus, a dangerous condition in which epileptic seizures follow one another for a duration of five or more minutes without the victim's regaining consciousness between them, is the second most common neurological emergency in the United States, with a recorded maximum of around 150,000-plus cases per year.

30 Jun 2018

KU Cancer Center launches clinical trial to eliminate radiation therapy for HER2-positive breast cancer

Researchers at The University of Kansas Cancer Center have launched a clinical trial that eliminates radiation from the treatment protocol for an invasive type of breast cancer that accounts for one-fifth of all breast cancer patients.

30 Jun 2018

City of Hope receives $3.7 million from CIRM to develop phase 1 glioblastoma trial

The California Institute for Regenerative Medicine board has awarded City of Hope $3.7 million to develop a phase 1 clinical trial for glioblastoma patients that will genetically engineer their stem cells to better tolerate chemotherapy's side effects, allowing them to receive higher doses of the therapy.

30 Jun 2018

DBS may slow progression of tremor for early-stage Parkinson's disease

Deep brain stimulation may slow the progression of tremor for early-stage Parkinson's disease patients, according to a Vanderbilt University Medical Center study released in the June 29 online issue of Neurology, the medical journal of the American Academy of Neurology.

30 Jun 2018

URI researchers working to develop novel medication to treat alcohol use disorder

Alcohol abuse is among the leading causes of preventable death in the United States, killing more than 88,000 people a year, according to the Centers for Disease Control.

28 Jun 2018

Genetic biomarker can help predict survival outcomes in patients with certain gliomas

A DNA-level biomarker (MGMT promoter methylation) can be used to help predict survival outcomes in patients with high-risk, low-grade gliomas, according to a new study conducted through the NRG Oncology/RTOG collaborative clinical trials group and led by scientists at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

28 Jun 2018

Worldwide study to examine new treatments for IgA nephropathy

A patient from Birmingham is the first person to be recruited into a new worldwide study to test new treatments for a potentially life-threatening kidney condition called IgA nephropathy.

28 Jun 2018

Researchers examine whether taking a hallucinogen can curb cocaine use

Unlike with alcohol or nicotine, there is not a pharmacological option available to individuals addicted to cocaine to help them stop using the drug. However, researchers at the University of Alabama at Birmingham believe the tool to help individuals treat their addiction may very well exist.

28 Jun 2018

New heat stable version of Carbetocin to prevent hemorrhage after birth

The World Health Organization (WHO) has said that a new heat stable version of a drug Carbetocin can save lives of new mothers could “revolutionize” therapy. The results of the study looking at the effectiveness of the new version of the drug were published in the latest issue of the New England Journal of Medicine.

28 Jun 2018

Even mild sleep disturbances can increase blood pressure in women

It is well known that chronic sleep deprivation can affect cardiovascular health. But according to a new study from Columbia University Irving Medical Center, even mild sleep problems, such as having trouble falling asleep, can raise blood pressure in women.

27 Jun 2018

New avenue for cancer treatment opens when one drug fails

A new class of cancer drugs – called CDK4/6 inhibitors -- recently approved to treat breast cancer can stunt the cancer's growth and replication.

27 Jun 2018

Phase 1 clinical trial of poliovirus therapy shows long-term survival benefit for recurrent glioblastoma

A genetically modified poliovirus therapy developed at Duke Cancer Institute shows significantly improved long-term survival for patients with recurrent glioblastoma, with a three-year survival rate of 21 percent in a phase 1 clinical trial.

26 Jun 2018

Patients receiving leadless pacemakers experience fewer complications, study finds

Patients receiving leadless pacemakers experience overall fewer short-term and mid-term complications than those receiving traditional transvenous pacemakers, a Cleveland Clinic-led research study found. The study was published today in the journal Heart Rhythm.

26 Jun 2018

Unbiased approach reveals how to restore breast cancer drugs’ tumor-killing potential

More than 60 percent of breast cancer cases involve defects in the same biochemical chain of events within cancer cells-- known as the PI3 kinase (PI3K) pathway--but efforts to develop therapies targeting this pathway have met with little success after hundreds of mostly failed clinical trials. And researchers still don't understand why.

26 Jun 2018

Genetic subset of prostate cancer may benefit from combination checkpoint immunotherapy

Researchers at the Johns Hopkins Kimmel Cancer Center and the Bloomberg~Kimmel Institute for Cancer Immunotherapy released a study investigating the use of combination checkpoint immunotherapy in the treatment of a lethal form of advanced prostate cancer.

25 Jun 2018

AAA doses first patients in two clinical studies with PSMA-R2 for prostate cancer

Advanced Accelerator Applications S.A., a Novartis company and leader in nuclear medicine theragnostics, today announced that the first patients have been dosed in two Phase I/II clinical studies of radiolabeled PSMA-R2, a urea-based ligand of Prostate-Specific Membrane Antigen, which is commonly expressed on prostate cancer cells.

22 Jun 2018

Researchers discover drug compound that inhibits movement of cancer cells

Fighting cancer means killing cancer cells. However, oncologists know that it's also important to halt the movement of cancer cells before they spread throughout the body.

22 Jun 2018

UC San Diego launches new bacteriophage therapy center

With microbial resistance to antibiotics growing into a major global health crisis, researchers at University of California San Diego School of Medicine, in collaboration with national research institutions and private industry, are leveraging hard-won expertise to exploit a natural viral enemy of pathogenic bacteria, creating North America's first Center for Innovative Phage Applications and Therapeutics

22 Jun 2018

Osteopathic manual therapy affecting the diaphragm improves chronic low back pain

Researchers have verified the effectiveness of a treatment with osteopathic manual therapy including specific techniques on the diaphragm.

22 Jun 2018

Novel cellular pathway may clarify how arterial inflammation develops into atherosclerosis

Investigators have identified a new cellular pathway that may help explain how arterial inflammation develops into atherosclerosis - deposits of cholesterol, fats and other substances that create plaque, clog arteries and promote heart attacks and stroke. The findings could lead to improved therapies for atherosclerosis, a leading cause of death worldwide.

22 Jun 2018

Clinical Trial News and Research

Study using i2b2 could help standardize artificial coma treatment for RSE patients

KU Cancer Center launches clinical trial to eliminate radiation therapy for HER2-positive breast cancer

City of Hope receives $3.7 million from CIRM to develop phase 1 glioblastoma trial

DBS may slow progression of tremor for early-stage Parkinson's disease

URI researchers working to develop novel medication to treat alcohol use disorder

Genetic biomarker can help predict survival outcomes in patients with certain gliomas

Worldwide study to examine new treatments for IgA nephropathy

Researchers examine whether taking a hallucinogen can curb cocaine use

New heat stable version of Carbetocin to prevent hemorrhage after birth

Even mild sleep disturbances can increase blood pressure in women

New avenue for cancer treatment opens when one drug fails

Phase 1 clinical trial of poliovirus therapy shows long-term survival benefit for recurrent glioblastoma

Patients receiving leadless pacemakers experience fewer complications, study finds

Unbiased approach reveals how to restore breast cancer drugs’ tumor-killing potential

Genetic subset of prostate cancer may benefit from combination checkpoint immunotherapy

AAA doses first patients in two clinical studies with PSMA-R2 for prostate cancer

Researchers discover drug compound that inhibits movement of cancer cells

UC San Diego launches new bacteriophage therapy center

Osteopathic manual therapy affecting the diaphragm improves chronic low back pain

Novel cellular pathway may clarify how arterial inflammation develops into atherosclerosis

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