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Researchers establish organoid culture models from prostate tumor biopsies

Scientists at Urology Research Laboratory of the Department for BioMedical Research, University of Bern and Urology Department of the Inselspital of Bern, have established organoid culture models from prostate tumor biopsies.

8 Mar 2021

Compounds in green and black tea relax blood vessels by activating ion channel proteins

A new study from the University of California, Irvine shows that compounds in both green and black tea relax blood vessels by activating ion channel proteins in the blood vessel wall.

8 Mar 2021

Continued vigilance needed as COVID lockdown is relaxed in England, warn researchers

Researchers have reported findings from round nine of the REal-time Assessment of Community Transmission Study (REACT-1) that estimates community prevalence of infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in England.

8 Mar 2021

New inhibitor makes drug-resistant tumor cells respond again to chemotherapy

A new substance could improve the treatment of persistent cancers. Researchers at Martin Luther University Halle-Wittenberg (MLU) and the University of Greifswald have developed a new inhibitor that makes drug-resistant tumour cells respond again to chemotherapy.

8 Mar 2021

Data from Israel’s vaccination program suggests Pizer-BioNTech COVID-19 vaccine induces strong host antibody response

A team of scientists from Israel has recently evaluated the efficacy of an mRNA-based coronavirus disease 2019 (COVID-19) vaccine, BNT162b2, in inducing host humoral immune response. The findings reveal that the vaccine is capable of inducing strong anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody response and that the response varies significantly with age. The study is currently available on the medRxiv* preprint server.

8 Mar 2021

FDA-approved drug has limited treatment efficacy for hypoactive sexual desire disorder

An independent analysis of the medical trials which formed the final basis of approval by the US Food and Drug Administration (FDA) strongly suggests the drug bremelanotide has very limited effectiveness as a treatment for hypoactive sexual desire disorder (HSDD) in women, and that trial participants preferred a placebo.

8 Mar 2021

Antidepressants provide no important benefits for managing low back pain

A new systematic review led by UNSW Sydney has found that treating low back pain with antidepressant medicines provides no important benefits and has the potential to cause harm.

8 Mar 2021

Monoclonal antibodies can be an effective tool in the global fight against malaria

Scientists at Walter Reed Army Institute of Research, in collaboration the Duke University, have confirmed that monoclonal antibodies can be an effective tool in the global fight against malaria.

8 Mar 2021

Despite modest progress, maternal and child undernutrition remains a key health concern

The Lancet today published the latest Series on Maternal and Child Undernutrition Progress, including three new papers that build upon findings from the previous 2008 and 2013 Series, which established an evidence-based global agenda for tackling undernutrition over the past decade.

8 Mar 2021

Study proposes a new, noninvasive way to detect kidney transplant rejection

Patients can spend up to six years waiting for a kidney transplant. Even when they do receive a transplant, up to 20 percent of patients will experience rejection.

5 Mar 2021

Researchers discover how adhesions form in the abdomen

Adhesions are scars in the abdomen, which can occur after surgery, often have serious consequences. Now, researchers from the University of Bern and Inselspital, University Hospital Bern, in collaboration with Canadian researchers, have discovered how such adhesions form.

5 Mar 2021

Social support for mothers of patients with eating disorders may help improve mothers' mental health

Although caregivers of patients with eating disorders usually experience a heavy caregiving burden, the effects of social support on caregivers of patients with eating disorders are unknown.

5 Mar 2021

ACTIV-3 clinical trial evaluating investigational COVID-19 therapies closes enrollment in two sub-studies

The ACTIV-3 clinical trial, which is evaluating the safety and efficacy of investigational therapeutics for COVID-19 in hospitalized patients, has closed enrollment in two sub-studies: one examining the investigational monoclonal antibody therapy VIR-7831, and another evaluating the investigational combination monoclonal antibody therapy containing BRII-196 and BRII-198.

5 Mar 2021

New approach using virtual clinical trials could revolutionize drug development

New cutting-edge research undertaken at the University of Leicester could revolutionize the way new drugs are developed and the way patients are cared for, through a pioneering new approach using virtual clinical trials

5 Mar 2021

One dose of SARS-CoV-2 vaccine candidate boosts neutralizing antibody response in COVID-19 convalescents

A new study details the results from a single dose of the FINLAY FR 1A recombinant dimeric receptor-binding domain (RBD) base vaccine during a phase I clinical trial with 30 COVID-19 convalescents to test its capacity for boosting natural immunity.

5 Mar 2021

A SARS-CoV-2 spike protein adjuvant vaccine candidate produces durable rapid protection in vivo

A recent study reports the safety and high efficacy of an adjuvanted vaccine candidate against SARS-CoV-2 and the complications of COVID-19.

5 Mar 2021

New COVID-19 variants can evade antibodies that work against original form of the virus

New research at Washington University School of Medicine in St. Louis indicates that three new, fast-spreading variants of the virus that cause COVID-19 can evade antibodies that work against the original form of the virus that sparked the pandemic.

5 Mar 2021

New evidence supports the use of antisense oligonucleotides as feasible therapeutic strategy for MDS

Many cognitive neurodevelopmental disorders are a result of too many or too few copies of certain genes or chromosomes.

5 Mar 2021

SARS-CoV-2-derived mutant peptides hamper T cells' ability to recognize and destroy infected cells

A deep sequencing study of 747 SARS-CoV-2 virus isolates has revealed mutant peptides derived from the virus that cannot effectively bind to critical proteins on the surface of infected cells and, in turn, hamper activation of CD8+ killer T cells that recognize and destroy these infected cells.

4 Mar 2021

Novavax COVID-19 vaccine shows efficacy against South African SARS-CoV-2 variant

Researchers in the United States and South Africa report that the NVX-CoV2373 vaccine from Novavax has proved effective at preventing coronavirus disease (COVID-19) caused by the B.1.351 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has recently emerged in South Africa.

4 Mar 2021

Efficacy News and Research

Researchers establish organoid culture models from prostate tumor biopsies

Compounds in green and black tea relax blood vessels by activating ion channel proteins

Continued vigilance needed as COVID lockdown is relaxed in England, warn researchers

New inhibitor makes drug-resistant tumor cells respond again to chemotherapy

Data from Israel’s vaccination program suggests Pizer-BioNTech COVID-19 vaccine induces strong host antibody response

FDA-approved drug has limited treatment efficacy for hypoactive sexual desire disorder

Antidepressants provide no important benefits for managing low back pain

Monoclonal antibodies can be an effective tool in the global fight against malaria

Despite modest progress, maternal and child undernutrition remains a key health concern

Study proposes a new, noninvasive way to detect kidney transplant rejection

Researchers discover how adhesions form in the abdomen

Social support for mothers of patients with eating disorders may help improve mothers' mental health

ACTIV-3 clinical trial evaluating investigational COVID-19 therapies closes enrollment in two sub-studies

New approach using virtual clinical trials could revolutionize drug development

One dose of SARS-CoV-2 vaccine candidate boosts neutralizing antibody response in COVID-19 convalescents

A SARS-CoV-2 spike protein adjuvant vaccine candidate produces durable rapid protection in vivo

New COVID-19 variants can evade antibodies that work against original form of the virus

New evidence supports the use of antisense oligonucleotides as feasible therapeutic strategy for MDS

SARS-CoV-2-derived mutant peptides hamper T cells' ability to recognize and destroy infected cells

Novavax COVID-19 vaccine shows efficacy against South African SARS-CoV-2 variant

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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