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Study: Estrogen may reduce severity of COVID-19 symptoms in women

Why are men at greater risk than women for more severe symptoms and worse outcomes from COVID-19 regardless of age?

27 Aug 2020

First lethal mouse model of SARS-CoV-2 developed

Army scientists have developed the first lethal mouse model of SARS-CoV-2, the virus that causes COVID-19, using mice that were genetically engineered to express the human ACE2 gene--a key mechanism by which the virus enters human cells.

27 Aug 2020

Gout drug may improve heart function in individuals with congenital heart disease

A drug used to treat gout, probenecid, may improve heart function in individuals with a particular heart defect, according to results from a small pilot study run by a University of Cincinnati researcher.

27 Aug 2020

Heat Biologics SARS-CoV-2 vaccine generates potent T cell response in pre-clinical trial

The COVID-19 pandemic is still creating economic and health-related impact over the world. A new study published on the preprint server bioRxiv in August 2020 shows that a gp96-Ig-secreting vaccine candidate based on the expression of full-length spike protein generates a potent T cell response.

26 Aug 2020

Study suggests memory B cells persist following COVID-19 recovery

Researchers at Tel Aviv University in Israel have gained valuable insights into the serological and B cell response to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

26 Aug 2020

Exosomes: The cancer cell communication mechanism

Professor Deborah Goberdhan speaks to News-Medical about her team's latest research into cancer cells, and the mechanisms they use to communicate.

26 Aug 2020

Premenopausal women previously treated with radiation have worse breast cancer-specific survival

Among premenopausal women with breast cancer, those who were previously treated with radiation for a primary childhood, adolescent, or young adult cancer had worse breast cancer-specific survival.

26 Aug 2020

Estradiol appears to help in female SARS-CoV-2 infection

A new study published on the preprint server medRxiv in August 2020 shows that the risk of infection is high for pre-menopausal women but the risk of death is much higher for men in the same age group and throws light on the protective nature of estradiol therapy in post-menopausal women.

26 Aug 2020

Researchers document comprehensive communication pathways in human cell infected with SARS-CoV-2

In the transmission of signals within the cell which, for example, stimulate cell growth or trigger metabolic processes, phosphate groups play an important biochemical role.

25 Aug 2020

Inhaled steroids reduce SARS-CoV-2-related genes in COPD

A new study published on the preprint server medRxiv* aims to explore the effects of treatment with ICS on the expression of specific genes related to SARS-CoV-2 infection in bronchial epithelial cells in a prospective interventional design.

25 Aug 2020

Antihypertensives reduce severity of Covid-19 infection and death

Medication for high blood pressure could improve Covid-19 survival rates and reduce the severity of infection - according to new research from the University of East Anglia.

25 Aug 2020

Study examines potential therapeutic approach for Alzheimer's disease

Research looking at a possible new therapeutic approach for Alzheimer's disease was recently published in the Journal of Neuroinflammation.

25 Aug 2020

COVID specific IgA monoclonal antibodies may provide effective immunity against coronavirus

A new study by researchers at MassBiologics of UMass Medical School published in Nature Communications suggests that COVID specific IgA monoclonal antibodies may provide effective immunity in the respiratory system against the novel coronavirus - a potentially critical feature of an effective vaccine.

25 Aug 2020

Highly expressed protein in lung cancer cells drives resistance to targeted therapies

A protein highly expressed in lung cancer cells drives resistance to targeted therapies, report researchers at the Medical University of South Carolina in the Journal of Thoracic and Cardiovascular Surgery.

25 Aug 2020

Single dose nasal vaccine against SARS-CoV-2 shows promise in animal studies

Now researchers at the Washington University School of Medicine in St. Louis have worked on developing a candidate vaccine against the infection that could be administered in a single dose via a nasal spray rather than an injection. In their preliminary studies using lab mice, this single dose of the nasal vaccine successfully prevented the infection with the novel coronavirus.

24 Aug 2020

Genomic analysis reveals many animal species vulnerable to SARS-CoV-2

Now, a new genomics study by University of California, Davis, California researchers identifies a large number of mammals that can potentially be infected by SARS-CoV-2 via their ACE2 proteins.

24 Aug 2020

Women with T1a breast cancers could benefit from hormone treatment

Many people diagnosed with breast cancers that are small but invasive could benefit from hormone treatment, a new study led by physicians at Roswell Park Comprehensive Cancer Center confirms. Their findings were published today in the journal JAMA Network Open.

24 Aug 2020

Study reveals protective potential of all three major immunoglobulin isotypes against SARS-CoV-2

In a recent medRxiv preprint paper, researchers from Mount Sinai in New York showed that all three major immunoglobulin isotypes (IgM, IgG, and IgA) produced by our immune cells were capable of mediating neutralization of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, neutralization titers correlated much better with binding levels of IgM and IgA1 than IgG.

24 Aug 2020

Lasting nature of IBD linked to a long-lived immune cell that provokes damaging inflammation

Inflammatory bowel disease (IBD) is a group of intestinal disorders affecting an estimated six to eight million people worldwide.

24 Aug 2020

Ferrets not susceptible to SARS-CoV-2 infection

A recent study by scientists at the Cummings School of Veterinary Medicine at Tufts University has revealed that ferrets are not susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection even if they are directly exposed to symptomatic coronavirus disease 2019 (COVID-19) patients for a prolonged time.

24 Aug 2020

Receptor News and Research

Study: Estrogen may reduce severity of COVID-19 symptoms in women

First lethal mouse model of SARS-CoV-2 developed

Gout drug may improve heart function in individuals with congenital heart disease

Heat Biologics SARS-CoV-2 vaccine generates potent T cell response in pre-clinical trial

Study suggests memory B cells persist following COVID-19 recovery

Exosomes: The cancer cell communication mechanism

Premenopausal women previously treated with radiation have worse breast cancer-specific survival

Estradiol appears to help in female SARS-CoV-2 infection

Researchers document comprehensive communication pathways in human cell infected with SARS-CoV-2

Inhaled steroids reduce SARS-CoV-2-related genes in COPD

Antihypertensives reduce severity of Covid-19 infection and death

Study examines potential therapeutic approach for Alzheimer's disease

COVID specific IgA monoclonal antibodies may provide effective immunity against coronavirus

Highly expressed protein in lung cancer cells drives resistance to targeted therapies

Single dose nasal vaccine against SARS-CoV-2 shows promise in animal studies

Genomic analysis reveals many animal species vulnerable to SARS-CoV-2

Women with T1a breast cancers could benefit from hormone treatment

Study reveals protective potential of all three major immunoglobulin isotypes against SARS-CoV-2

Lasting nature of IBD linked to a long-lived immune cell that provokes damaging inflammation

Ferrets not susceptible to SARS-CoV-2 infection

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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