Therapeutics News and Research

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Helsinn, Mundipharma sign distribution, license and supply agreements for anamorelin

Helsinn, the Swiss pharmaceutical Group focused on building quality cancer care, today announce that they have entered into distribution, license and supply agreements with Mundipharma and its network of independent associated companies granting exclusive rights to anamorelin in Norway, Finland, Sweden, Denmark and Iceland.

16 Feb 2016

Variations in Tie2 gene play significant role in patient responses to infections

Major infections such as influenza and bacterial sepsis kill millions of people each year, often resulting fro dangerous complications that impair the body's blood vessels. But the reasons why some patients experience these dramatic responses to infections -- and others don't -- have been unclear.

16 Feb 2016

TUM researchers make progress in bringing immunotherapy to fight against cancer, infectious diseases

The quest to bring immunotherapy into widespread clinical use against cancer and infectious diseases has made great strides in recent years.

15 Feb 2016

Neural gene promotes growth and spread of metastatic breast cancer

When breast cancer becomes advanced and spreads to other organs, patient survival is drastically reduced, prompting the need to explore the genes that may cause tumor cells to metastasize.

15 Feb 2016

Australian researchers identify genetic map of human parasitic scabies mite

Australian researchers have used cutting-edge genome technologies to reveal the genetic makeup of a widespread skin parasite causing serious health problems in Aboriginal communities.

15 Feb 2016

TAU research highlights neuroprotective potential of protein-protectant drug candidate SKIP

Activity-dependent neuroprotective protein (ADNP), essential for brain formation, is frequently mutated in children on the autism spectrum. In older men and women, ADNP expression in the blood is correlated with cognition and further altered in Alzheimer's disease.

11 Feb 2016

Unlocking intrinsically disordered proteins: an interview with Peter Wright

I'm a professor in the Department of Integrative Structural and Computational Biology at The Scripps Research Institute. I have been performing NMR research on proteins for nearly 40 years.

From Bruker BioSpin Group 11 Feb 2016

UPMC uses simple gene test to personalize medications for patients undergoing heart catheterization

Patients who go to UPMC Presbyterian for heart catheterization and who receive a stent to treat clogged arteries are now being screened with a simple blood test to determine if they have a gene variant that makes them less likely to respond to a blood-thinning medication commonly prescribed after the procedure.

11 Feb 2016

Fasudil improves memory in rats, promotes degradation of toxic tau in the eyes of fruit flies

Could a kinase inhibitor some doctors prescribe to keep blood flowing after brain surgery be used to treat neurodegeneration? New research suggests it might be worth exploring the question.

10 Feb 2016

2D-NMR could be a powerful complementary technique for assessing biosimilarity of protein drugs

A first-ever interlaboratory study of four versions of a therapeutic protein drug—all manufactured from living cells—reports that an established analytical tool akin to magnetic resonance imaging reliably assessed the atomic structures of the biologically similar products, yielding the equivalent of a fingerprint for each.

10 Feb 2016

Oral therapeutic drug shows promise against recurrent C. difficile infection

Results from a Phase 1b/2 trial suggest that an investigational microbiome-based, oral therapeutic drug is effective for the treatment of recurrent C. difficile infection. In a paper published online in the Journal of Infectious Diseases, a multi-institutional research team reports that treatment with the preparation, containing the spores of approximately 50 species of beneficial bacteria, successfully prevented recurrence of C. difficile infection (CDI) in patients with a history of multiple recurrent disease.

10 Feb 2016

FDA requests $5.1 billion budget for FY 2017 to protect and promote public health

The U.S. Food and Drug Administration is requesting a total budget of $5.1 billion to protect and promote the public health as part of the President's fiscal year (FY) 2017 budget – an eight percent increase over the enacted budget for FY 2016.

10 Feb 2016

Medical marijuana offers hope for kids with uncontrolled seizures

Desperate for relief, parents are taking unusual steps to help children plagued with seizures. The relief, however, comes in a most unlikely form: marijuana.

9 Feb 2016

FDA clears Sangamo BioSciences' SB-318 IND application for treatment of MPS I

Sangamo BioSciences, Inc., the leader in therapeutic genome editing, announced that the U.S. Food and Drug Administration has cleared the Company's Investigational New Drug (IND) application for SB-318, a single treatment strategy intended to provide a life-long therapy for Mucopolysaccharidosis Type I (MPS I).

8 Feb 2016

LouLou Foundation, Penn Med set up Program of Excellence to develop treatments for children with CDKL5

The London-based LouLou Foundation and the Orphan Disease Center of the Perelman School of Medicine at the University of Pennsylvania have established a Program of Excellence to develop effective treatments for children with CDKL5, a rare X-chromosome-linked genetic disorder that causes severe neuro-developmental impairment and early-onset, difficult-to-control seizures.

8 Feb 2016

Rockefeller University study shows how herpes virus causes traffic jam in immune system pathway

With over half the U.S. population infected, most people are familiar with the pesky cold sore outbreaks caused by the herpes virus. The virus outsmarts the immune system by interfering with the process that normally allows immune cells to recognize and destroy foreign invaders. How exactly the herpes simplex 1 virus pulls off its nifty scheme has long been elusive to scientists.

4 Feb 2016

Cell Therapy Catapult becomes Cell and Gene Therapy Catapult

The Cell Therapy Catapult, the UK organisation dedicated to the growth of the UK cell and gene therapy industry by bridging the gap between scientific research and commercialisation, today announces the official change of its name to the Cell and Gene Therapy Catapult.

4 Feb 2016

New drug cocktail may show promise in NSCLC patients

A drug approved by the Food and Drug Administration for melanoma in combination with a common cholesterol-lowering drug may show promise in controlling cancer growth in patients with non-small cell lung cancer (NSCLC), according to new research from the Icahn School of Medicine at Mount Sinai.

3 Feb 2016

ST Asia signs licensing deal with PharmaMar to distribute new multiple myeloma drug in South East Asia

International biopharmaceutical company Specialised Therapeutics Asia will supply and distribute a novel oncology drug candidate throughout South East Asia, following an exclusive licensing deal with European pharmaceutical company PharmaMar.

3 Feb 2016

New way to more efficiently deliver CRISPR/Cas9 therapeutic to mice with Tyrosinemia type I

University of Massachusetts Medical School researchers have found a way to more efficiently delivery a CRISPR/Cas9 therapeutic to adult mice with the metabolic disease Tyrosinemia type I that may also prove to be safer for use in humans.

2 Feb 2016

Therapeutics News and Research

Helsinn, Mundipharma sign distribution, license and supply agreements for anamorelin

Variations in Tie2 gene play significant role in patient responses to infections

TUM researchers make progress in bringing immunotherapy to fight against cancer, infectious diseases

Neural gene promotes growth and spread of metastatic breast cancer

Australian researchers identify genetic map of human parasitic scabies mite

TAU research highlights neuroprotective potential of protein-protectant drug candidate SKIP

Unlocking intrinsically disordered proteins: an interview with Peter Wright

UPMC uses simple gene test to personalize medications for patients undergoing heart catheterization

Fasudil improves memory in rats, promotes degradation of toxic tau in the eyes of fruit flies

2D-NMR could be a powerful complementary technique for assessing biosimilarity of protein drugs

Oral therapeutic drug shows promise against recurrent C. difficile infection

FDA requests $5.1 billion budget for FY 2017 to protect and promote public health

Medical marijuana offers hope for kids with uncontrolled seizures

FDA clears Sangamo BioSciences' SB-318 IND application for treatment of MPS I

LouLou Foundation, Penn Med set up Program of Excellence to develop treatments for children with CDKL5

Rockefeller University study shows how herpes virus causes traffic jam in immune system pathway

Cell Therapy Catapult becomes Cell and Gene Therapy Catapult

New drug cocktail may show promise in NSCLC patients

ST Asia signs licensing deal with PharmaMar to distribute new multiple myeloma drug in South East Asia

New way to more efficiently deliver CRISPR/Cas9 therapeutic to mice with Tyrosinemia type I

Understanding the DNA Damage Response in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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