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Detection and targeting of splicing deregulation reveal a potential strategy for pAML therapy

Pediatric acute myeloid leukemia or pAML is a childhood blood cancer, one that has proved confounding to clinicians and researchers, with a high relapse rate and relatively few identified genetic mutations (compared to the adult version) that might explain its cause.

8 Mar 2023

Girls in Texas could get birth control at federal clinics, until a Christian father objected

On the vast Texas Panhandle, raked by wind and relentless sun, women might drive for hours to reach Haven Health, a clinic in Amarillo.

8 Mar 2023

First-in-woman study of a non-hormonal vaginal film showed safety, potential contraceptive efficacy, and supports future development

Researchers developed a novel contraceptive 'ZB-06' a vaginal film containing a human contraceptive antibody called HC4-N that agglutinates sperm.

7 Mar 2023

High-dose anticoagulation can reduce deaths, intubations in hospitalized COVID-19 patients

High-dose anticoagulation can reduce deaths by 30 percent and intubations by 25 percent in hospitalized COVID-19 patients who are not critically ill when compared to the standard treatment, which is low-dose anticoagulation.

6 Mar 2023

Non-critically ill hospitalized Covid-19 patients could substantially benefit from a higher dose of blood-thinners

Giving noncritically ill patients hospitalized for COVID-19 a higher dose of blood-thinning medication than usual did not significantly reduce the combined risk of death from any cause, need for treatment in an intensive-care unit, a confirmed blood clot or a stroke at 30 days, according to the results of the FREEDOM-COVID trial presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.

6 Mar 2023

Addition of sotatercept to existing therapy shows promise for the treatment of pulmonary arterial hypertension

Patients with pulmonary arterial hypertension (PAH), a severe, progressive condition that affects the heart and lungs, who were treated with the novel first-in-class medication sotatercept on top of existing therapy experienced significant improvements in walking distance via a six-minute walking test—the study's primary endpoint and a validated surrogate for functional improvement and reduced symptom burden.

6 Mar 2023

Minimally invasive mitral valve repair is as safe and effective as conventional surgery, trial shows

In the largest randomized trial conducted to compare minimally invasive and conventional cardiac surgical techniques for repairing a poorly functioning mitral valve, improvements in physical activity, as well as surgical outcomes and quality of life, were similar in both groups of patients at 12 weeks post-surgery.

5 Mar 2023

Existing CT scans estimate hardened fatty plaque deposits in the heart's largest blood vessels

Instead of special heart scans, physicians can use images of the chest captured months earlier, and for other reasons, to estimate patients' risk of heart attack or death during several kinds of major surgeries, a new study shows.

2 Mar 2023

Toolkit for treating obstetric hemorrhage saves lives, lowers health care costs

Measures used at California hospitals to stop excessive bleeding in childbirth are saving an average of almost $18 per birth, for statewide annual health care savings of $9 million, according to new research by scientists at Stanford Medicine and the California Maternal Quality Care Collaborative.

2 Mar 2023

Promising alternative strategy for islet transplantation in people with type 1 diabetes

In people with type 1 diabetes, the body's immune system attacks and destroys insulin-producing β cells that control blood glucose levels and are part of a group of cells in the pancreas called pancreatic islets.

1 Mar 2023

New insight on the uptick in colorectal cancer diagnoses and deaths among younger people

For years, colorectal cancer was believed by many to primarily impact older people; however, in recent years, there has been an uptick in colorectal cancer diagnoses and deaths among younger people ranging in age from their mid-20s to late 50s.

28 Feb 2023

Popular artificial sweetener associated with elevated risk of heart attack and stroke, study shows

New Cleveland Clinic research showed that erythritol, a popular artificial sweetener, is associated with an increased risk of heart attack and stroke.

27 Feb 2023

Cedars-Sinai investigator receives award for research identifying racial disparities in treatment for uterine fibroids

Rebecca Schneyer, MD, has received the Medstar National Center for Advanced Pelvic Surgery Diversity and Inclusion Award given by the Foundation of the AAGL.

24 Feb 2023

One Texas judge will decide fate of abortion pill used by millions of American women

Federal judges in Texas have delivered time and again for abortion opponents.

24 Feb 2023

Minimally invasive focused ultrasound treatment improves symptoms in patients with Parkinson's disease

Patients with Parkinson's disease achieved a significant improvement in their tremors, mobility, and other physical symptoms after having a minimally invasive procedure involving focused ultrasound, according to a new study today published in the New England Journal of Medicine.

23 Feb 2023

Using blood pressure medications after endovascular treatment for stroke may not be safe or effective

Using blood pressure medications to lower the top number of blood pressure reading (systolic blood pressure) may not be safe or effective among people who have an acute ischemic stroke and undergo a successful mechanical clot removal — endovascular therapy, according to a phase-2 late-breaking clinical trial presented today at the American Stroke Association's International Stroke Conference 2023.

13 Feb 2023

Two cardiovascular drugs may help improve outcomes for patients who experienced small vessel stroke

A study of two widely used cardiovascular medications — cilostazol and isosorbide mononitrate — in more than 350 patients confirmed the two medications were well-tolerated and safe for people who have experienced a stroke in a small blood vessel deep in the brain.

13 Feb 2023

Bleeding News and Research

Detection and targeting of splicing deregulation reveal a potential strategy for pAML therapy

Girls in Texas could get birth control at federal clinics, until a Christian father objected

First-in-woman study of a non-hormonal vaginal film showed safety, potential contraceptive efficacy, and supports future development

High-dose anticoagulation can reduce deaths, intubations in hospitalized COVID-19 patients

Non-critically ill hospitalized Covid-19 patients could substantially benefit from a higher dose of blood-thinners

Addition of sotatercept to existing therapy shows promise for the treatment of pulmonary arterial hypertension

Minimally invasive mitral valve repair is as safe and effective as conventional surgery, trial shows

Existing CT scans estimate hardened fatty plaque deposits in the heart's largest blood vessels

Toolkit for treating obstetric hemorrhage saves lives, lowers health care costs

Promising alternative strategy for islet transplantation in people with type 1 diabetes

New insight on the uptick in colorectal cancer diagnoses and deaths among younger people

Popular artificial sweetener associated with elevated risk of heart attack and stroke, study shows

Cedars-Sinai investigator receives award for research identifying racial disparities in treatment for uterine fibroids

One Texas judge will decide fate of abortion pill used by millions of American women

Minimally invasive focused ultrasound treatment improves symptoms in patients with Parkinson's disease

Using blood pressure medications after endovascular treatment for stroke may not be safe or effective

Two cardiovascular drugs may help improve outcomes for patients who experienced small vessel stroke

Doctors are disappearing from emergency rooms as hospitals look to cut costs

New tool to manage postpartum hemorrhage found to be safe and effective

Disruptions to the normal fllow of brain fluid linked to neurological conditions

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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