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Gene discovery could help develop new tools to prevent strokes and heart attacks

Heart attacks and strokes are a leading cause of death in the United States, but scientists are still working to understand one of their primary triggers.

11 Aug 2022

Study highlights the urgent need for combinatorial drug therapies for SARS-CoV-2

Researchers investigated the susceptibility of naturally-occurring severe acute respiratory syndrome coronavirus 2 main protease variants to protease inhibitor drugs, including nirmatrelvir and ensitrelvir.

11 Aug 2022

Study identifies multiple pathways adopted by SARS-CoV-2 to develop resistance to nirmatrelvir

Researchers demonstrated multiple routes SARS-CoV-2 might take to develop high-level resistance to nirmatrelvir, an oral antiviral targeting the 3C-like protease (3CLpro) of SARS-CoV-2.

11 Aug 2022

OICR funding to help five research projects take the next step toward advancing cancer care

Five Ontario-based research projects will take the next step toward advancing cancer care in the province thanks to funding from the Ontario Institute for Cancer Research (OICR).

11 Aug 2022

No, the Senate-passed reconciliation bill won’t strip $300 billion from Medicare

As Senate Democrats raced to pass what could be their final piece of major legislation before the midterm elections, critics went to the airwaves to blast the proposal as hurting older Americans who rely on Medicare.

11 Aug 2022

They call it ‘tranq’ — and it’s making street drugs even more dangerous

Approaching a van that distributes supplies for safer drug use in Greenfield, Massachusetts, a man named Kyle noticed an alert about xylazine.

11 Aug 2022

Sniffing out cancer with insect olfactory neural circuits

A fascinating new preprint reports the results of examining the VOC composition from individual cell cultures derived from human oral cancers, using an experimental setup employing an insect brain with attached antenna.

11 Aug 2022

Repurposed drug shows promise as potential new treatment for motor neuron disease

A drug typically used to treat enlarged prostates and high blood pressure has shown promise as a potential new therapy for motor neuron disease (MND), according to a new study.

11 Aug 2022

Interferon beta reduces binding of three components to RBCs, study finds

Drugs called interferon betas are common treatments for multiple sclerosis (MS), reducing relapses and slowing motor function decline. Interferon beta, a protein known to contain a zinc binding pocket, is thought to reduce proinflammatory molecules and even increase production of anti-inflammatory species in MS patients.

11 Aug 2022

PET imaging could help measure the pharmacodynamic effects of using STING-activating drugs

Stimulator of interferon genes, or STING, helps regulate immune activation. Thus, drugs that activate STING are being tested as a form of cancer immunotherapy and for treating certain infections.

11 Aug 2022

New computation-guided approach to identify small molecule corrector drugs for p53 hotspot mutations

A new study, led by researchers from the University of California, Irvine and the University of California, San Diego, reveals a new computation-guided approach to identify small molecules that can restore aspects of wild-type p53 tumor suppression function to mutated p53, which play an important role in many human cancers.

11 Aug 2022

New compound proves to be potent against more than 300 drug-resistant bacteria

Urinary tract infections are common, yet are increasingly tough to treat because the bacteria that cause them are becoming resistant to many antibiotics.

10 Aug 2022

A low-energy, high FODMAP diet in prediabetes and diabetes?

Researchers summarize the available knowledge on FODMAPs and suggest that they can play a role in the prevention and treatment of diabetes.

10 Aug 2022

Scientists discover new target for treatment of premature aging disorders

A stretch of DNA that hops around the human genome plays a role in premature aging disorders, scientists at the Salk Institute and King Abdullah University of Science and Technology in Saudi Arabia have discovered.

10 Aug 2022

UTSW scientists discover mechanism of RNA capping by SARS-CoV-2 virus

A team led by UT Southwestern researchers has identified how SARS-CoV-2, the virus that causes COVID-19, builds a structure called the RNA cap that's critical for successful viral replication.

10 Aug 2022

Scientists explore ecological firewalls for the containment of synthetic microbes

In a new study, researchers described ecological firewalls (EFWs) to contain synthetic microbes.

10 Aug 2022

Formulary restrictions may increase the risk of stroke in patients with atrial fibrillation

Atrial fibrillation (AF) is a major risk factor for stroke, and for decades the anticoagulant warfarin was the standard treatment for lowering that hazard. However, numerous drug and food interactions make warfarin burdensome for patients.

10 Aug 2022

Review of natural products with promising anti-SARS-CoV-2 potential

In a new study, researchers reviewed existing literature on naturally active products with therapeutic efficacy against SARS-CoV-2.

10 Aug 2022

Scientists conduct comparative analysis of monkeypox virus profilin-like proteins and human profilin proteins

In a new study, researchers explored monkeypox virus proteomics and structural characteristics of the A42R protein, the only MPXV protein in the RCSB PDB (protein data bank) and the only profilin-like protein of poxviruses with known structure.

10 Aug 2022

The features of the newly emerging SARS-CoV-2 Omicron BA.2.75 subvariant

Researchers evaluated all the features, especially the antigenic properties and transmission potential of SARS-CoV-2 Omicron sub-variant BA.2.75.

10 Aug 2022

Drugs News and Research

Gene discovery could help develop new tools to prevent strokes and heart attacks

Study highlights the urgent need for combinatorial drug therapies for SARS-CoV-2

Study identifies multiple pathways adopted by SARS-CoV-2 to develop resistance to nirmatrelvir

OICR funding to help five research projects take the next step toward advancing cancer care

No, the Senate-passed reconciliation bill won’t strip $300 billion from Medicare

They call it ‘tranq’ — and it’s making street drugs even more dangerous

Sniffing out cancer with insect olfactory neural circuits

Repurposed drug shows promise as potential new treatment for motor neuron disease

Interferon beta reduces binding of three components to RBCs, study finds

PET imaging could help measure the pharmacodynamic effects of using STING-activating drugs

New computation-guided approach to identify small molecule corrector drugs for p53 hotspot mutations

New compound proves to be potent against more than 300 drug-resistant bacteria

A low-energy, high FODMAP diet in prediabetes and diabetes?

Scientists discover new target for treatment of premature aging disorders

UTSW scientists discover mechanism of RNA capping by SARS-CoV-2 virus

Scientists explore ecological firewalls for the containment of synthetic microbes

Formulary restrictions may increase the risk of stroke in patients with atrial fibrillation

Review of natural products with promising anti-SARS-CoV-2 potential

Scientists conduct comparative analysis of monkeypox virus profilin-like proteins and human profilin proteins

The features of the newly emerging SARS-CoV-2 Omicron BA.2.75 subvariant

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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