Efficacy News and Research

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New tool tracks symptoms, assists healthcare providers to evaluate the effectiveness of treatment

Researchers from Regenstrief Institute and Indiana University School of Medicine have developed and validated a short questionnaire to help patients report symptoms and assist healthcare providers in assessing the severity of symptoms, and in monitoring and adjusting treatment accordingly.

16 Feb 2021

Mink-derived SARS-CoV-2 mutations reduce antibody effectiveness

A new preprint research paper posted to the bioRxiv* server shows that these mutations disrupt inhibition by neutralizing antibodies, both natural and therapeutic.

16 Feb 2021

Researchers create new cancer optotheranostics based on photosynthetic bacteria

Cancer is one of the most thought-provoking healthcare problems throughout the world. The development of therapeutic agents with highly selective anti-cancer activities is increasingly attractive due to the lack of tumor selectivity of conventional treatments.

16 Feb 2021

Nanoparticle COVID-19 vaccine stimulates robust and long lasting immunity in primates

In the study, published on the preprint server bioRxiv, the team evaluated the ability of AS03, CpG 1018 formulated in Alum, the TLR-7 agonist adsorbed to Alum (AS37), the squalene-in-water emulsion (O/W), and Alum to boost protective immunity against SARS-CoV-2.

15 Feb 2021

Study suggests a new way to personalize anti-CTLA-4 therapy for cancers

A Ludwig Cancer Research study has identified a novel mechanism by which a type of cancer immunotherapy known as CTLA-4 blockade can disable suppressive immune cells to aid the destruction of certain tumors.

15 Feb 2021

Researchers report a new SARS-CoV-2 variant of concern in Uganda

An interdisciplinary research team from Uganda and the UK report the emergence and spread of a new SARS-CoV-2 variant of the A lineage with multiple protein changes throughout the viral genome.

15 Feb 2021

SARS-CoV-2 South Africa and Brazil variants show resistance to therapeutic antibodies

Scientists from Germany have determined the efficacy of currently used therapeutics in treating newer variants of SARS-CoV-2, including the UK, South Africa, and Brazil variants. Their findings reveal that both B.1.351 and B.1.1.248 variants are able to escape humoral immune responses induced by therapeutic antibodies, vaccinations, or natural SARS-CoV-2 infection.

15 Feb 2021

RIG-1-like receptors may play dominant role in suppressing SARS-CoV-2 infection

A new study by researchers at the University of Connecticut Health Center, USA, reports the crucial nature of the pathogen pattern recognition receptor (PRRs), especially the two RLRs, retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), in triggering host cell immune responses within the cell. The RLRs are viral RNA sensors.

15 Feb 2021

LifeArc supports the GenOMICC COVID-19 Study

Medical research charity, LifeArc, announces today that it is providing £5 million funding to support the work of the GenOMICC COVID-19 Study, led by the GenOMICC consortium in partnership with Genomics England.

15 Feb 2021

A machine learning approach to identify drugs that could be repurposed to fight COVID-19

When the Covid-19 pandemic struck in early 2020, doctors and researchers rushed to find effective treatments. There was little time to spare.

15 Feb 2021

Innovations in Forensic Examination of Seized Drugs and Forensic Toxicology

NewsMed interviews Michelle Peace on her Pittcon presentation entitled, "Innovations in Forensic Examination of Seized Drugs and Forensic Toxicology".

From Pittcon 15 Feb 2021

Nanobodies protect against SARS-CoV-2 variants in animal model

Nanobodies are a potential therapeutic strategy for treating COVID-19. While many previous studies report nanobodies active against SARS-CoV-2 in vitro, none have been evaluated via animal models' intranasal administration.

15 Feb 2021

Premature relaxation of restrictions following SARS-CoV-2 vaccination could lead to new mutations

A new preprint research paper posted to the medRxiv* server addresses the need to assess this risk by examining whether SARS-CoV-2 transmission can interact with vaccination rates to select vaccine-resistant strains. The study aims to provide data to shape effective countermeasures against the threat of viral resistance.

14 Feb 2021

How effective has the COVID-19 vaccination program been in Israel?

Using publicly available coronavirus disease 2019 (COVID-19) data from Israel, a study suggests the BioNTech-Pfizer BNT162b2 vaccine is proving highly effective in the real world.

12 Feb 2021

Scientists demonstrate how glue points and sequence alignment information can flag residue SARS-CoV-2 variants

Researchers in the U.S. have demonstrated how dominant energetic landscape mappings or glue points, along with sequence alignment information can potentially identify key residue mutations and spike protein deletions tied with emerging variants.

12 Feb 2021

Health education program reduces risk of cardiovascular disease

People who participated in a health education program that included both mental health and physical health information significantly reduced their risks of cardiovascular disease and other chronic diseases by the end of the 12-month intervention - and sustained most of those improvements six months later, researchers found.

12 Feb 2021

New SARS-CoV-2 variant found in newborn child with seizures in the United States

Researchers at a hospital in Washington D.C. found a new mutant strain of the virus in a neonatal patient with high viral loads. According to the authors, this strain could be spreading in the United States mid-Atlantic population and needs monitoring.

11 Feb 2021

Scent detection dogs can be used to screen and identify COVID-19-infected individuals

In a recent article in the Journal of Osteopathic Medicine, authors gathered previously published research to summarize current thinking on the feasibility and efficacy of using scent detection dogs to screen for the COVID-19 virus.

11 Feb 2021

SARS-CoV-2 evolves antibody resistance in immunocompromised patient

Researchers in the United States who tracked the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an immunocompromised patient found that convalescent plasma therapy was associated with the emergence of viral variants that were less susceptible to neutralizing antibodies.

11 Feb 2021

Short duration, poor-quality sleep may increase risk of dementia and earlier death in elderly people

Sleep and health are inextricably connected. New research from investigators at Brigham and Women's Hospital explores the connection between sleep disturbances and deficiencies among older adults and risk of dementia and death, finding that risk of dementia was double among participants who reported getting less than five hours of sleep compared to those who reported 7-8 hours of sleep per night.

11 Feb 2021

Efficacy News and Research

New tool tracks symptoms, assists healthcare providers to evaluate the effectiveness of treatment

Mink-derived SARS-CoV-2 mutations reduce antibody effectiveness

Researchers create new cancer optotheranostics based on photosynthetic bacteria

Nanoparticle COVID-19 vaccine stimulates robust and long lasting immunity in primates

Study suggests a new way to personalize anti-CTLA-4 therapy for cancers

Researchers report a new SARS-CoV-2 variant of concern in Uganda

SARS-CoV-2 South Africa and Brazil variants show resistance to therapeutic antibodies

RIG-1-like receptors may play dominant role in suppressing SARS-CoV-2 infection

LifeArc supports the GenOMICC COVID-19 Study

A machine learning approach to identify drugs that could be repurposed to fight COVID-19

Innovations in Forensic Examination of Seized Drugs and Forensic Toxicology

Nanobodies protect against SARS-CoV-2 variants in animal model

Premature relaxation of restrictions following SARS-CoV-2 vaccination could lead to new mutations

How effective has the COVID-19 vaccination program been in Israel?

Scientists demonstrate how glue points and sequence alignment information can flag residue SARS-CoV-2 variants

Health education program reduces risk of cardiovascular disease

New SARS-CoV-2 variant found in newborn child with seizures in the United States

Scent detection dogs can be used to screen and identify COVID-19-infected individuals

SARS-CoV-2 evolves antibody resistance in immunocompromised patient

Short duration, poor-quality sleep may increase risk of dementia and earlier death in elderly people

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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