Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

miR 155 overexpression can lead to cancer

Scientists in the Ohio State University Comprehensive Cancer Center say that just one, single, malfunctioning microRNA is sufficient to cause cancer in mice.

18 Apr 2006

Researchers develop system for observing nuclear motion

The cell is understood to be highly organized, with specialized areas for different functions and molecular motors shuttling components around.

18 Apr 2006

Important new global mechanism for gene repression

Most of the time in most cells of the body, the great majority of genes are silenced, locked away within the compacted but orderly material that makes up chromosomes.

18 Apr 2006

Nimesulide fights breast cancer by targeting key enzyme

A pain-killing medication appears to halt the production of an enzyme that is key to a common form of breast cancer, a new study using tissue cultures suggests.

16 Apr 2006

Researchers find genetic "signature" that accurately identifies colon cancer

Researchers at Jefferson Medical College in Philadelphia have uncovered a genetic "signature" that accurately identifies colon cancer--a key, they hope, to better understand how the cancer develops.

13 Apr 2006

Active ingredient in soy may explain why Asians have lower rates of obesity and cancer

A single nutrient found in soy products elicits changes in gene behavior that permanently reduce an embryo's risk of becoming obese later in life, according to an animal study at Duke University Medical Center.

13 Apr 2006

Researchers identify the role of a protein in hemoglobin gene silencing

Virginia Commonwealth University Massey Cancer Center researchers have identified the role of a protein in hemoglobin gene silencing that may one day be a potential target for the treatment of genetic blood disorders like sickle-cell anemia and beta-thalassemia on the molecular level.

11 Apr 2006

New model of p53 regulation has important implications for the development of anticancer drugs

Genetically engineered mice convinced scientists at the Salk Institute for Biological Studies that it was time to overhaul widely held beliefs about how a powerful tumor suppressor called p53 is controlled in cells. Their new model of p53 regulation has important implications for the development of anticancer drugs.

11 Apr 2006

Colorimetric screening detects DNA, small molecules and proteins

Using the unusual color properties of gold at the nanoscale, scientists at Northwestern University have developed a "litmus test" for DNA and small molecule binding that eventually could be used by pharmaceutical companies to rapidly identify promising candidates for new anti-cancer drugs.

11 Apr 2006

A genomic signature of 254 genes predicting clinical outcome in Primary Cutaneous Melanoma identified

EORTC Melanoma Group researchers have identified a genomic signature predicting clinical outcome in Primary Cutaneous Melanoma, after patients having undergone standard treatment.

6 Apr 2006

Researchers narrow search for effective prostate cancer biomarkers

Researchers at Mayo Clinic have narrowed the search for effective prostate cancer biomarkers (genetic variations that point to a specific disease or condition), identifying changes in the expression of genes of the whole genome closely correlated to prostate cancer development and progression.

4 Apr 2006

HOXB13 and IL17BR genes predict outcome for breast cancer patients

The 2-gene expression profile of HOXB13 and IL17BR in a woman's breast cancer predicts risk of recurrence in node-negative patients treated with tamoxifen.

4 Apr 2006

Mitochondria induce nuclear deformation

In a paper being presented in two American Physiological Society sessions at Experimental Biology 2006, a joint Estonian-French team demonstrated "for the first time that mitochondria are able to induce nuclear deformation, suggesting that mitochondria may mechanically regulate nuclear function."

4 Apr 2006

Weill Cornell experts publish review of genetic medicine

In an article published in the April issue of Nature Reviews Genetics, two experts at the Weill Medical College of Cornell University sum up the achievements, challenges and promise of a burgeoning field: genetic medicine.

3 Apr 2006

Mouse Brain Gene Expression Map at St. Jude - powerful new tool for studying brain development

Scientists at St. Jude Children's Research Hospital have given investigators around the world free access to a powerful tool for studying brain development.

28 Mar 2006

Real-time molecule-by-molecule "movie" of protein production in live cells

Chemists at Harvard University have developed the first technique providing a real-time, molecule-by-molecule "movie" of protein production in live cells.

19 Mar 2006

Studying the gene-expression profiles of patients with colorectal cancer might help predict their response to chemotherapy

Studying the gene-expression profiles of patients with colorectal cancer might help predict their response to chemotherapy.

15 Mar 2006

Scientists have gained valuable new insight into the biology of aggressive, incurable brain tumors

A research study published in the March issue of Cancer Cell uses gene expression profiling to identify molecular profiles and signaling pathways associated with tumor aggressiveness and disease progression.

15 Mar 2006

Man-made chemical compound targets and kills tumor cells

A man-made chemical compound called ARC causes tumor cells to die but leaves normal cells unharmed, researchers at the University of Illinois at Chicago report in a study highlighted in the March 15 issue of Cancer Research.

15 Mar 2006

Researchers find viable new sources for stem cell transplants to the heart

Stem cell transplantation is among one of the most exciting and hotly debated areas of medical research today. While the promise of personalized medicine and effective treatments for debilitating diseases drive progress in this area, moral and ethical dilemmas about embryonic cells continues to cloud the field.

14 Mar 2006