Bioinformatics News and Research

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Bioinformatics is the application of information techniques for the storage, retrieval, and analysis of large quantities of biological data.

New METPlatform allows researchers to test drugs for possible use in brain metastases

It is estimated that about a quarter of cancer patients are at risk of brain metastases, a rate that is increasing especially among those who suffer relapses after having undergone different cancer treatments.

17 Feb 2022

Study helps understand actionable genetic variation affecting drugs in the Middle East population

A group of researchers at Qatar Foundation have reported the first comprehensive study of the distribution of actionable genetic variation affecting drugs in any Middle Eastern population, with potential implications for preemptive pharmacogenomic implementation in the region.

16 Feb 2022

New DisCo method allows scRNA-seq to efficiently process samples with fewer cells

Single-cell RNA sequencing, or "scRNA-seq" for short, is a technique that allows scientists to study the expression of genes in an individual cell within a mixed population – which is virtually how all cells exist in the body's tissues.

15 Feb 2022

Artificial intelligence uses facial features to better diagnose rare genetic diseases

Rare genetic diseases can sometimes be recognized through facial features, such as characteristically shaped brows, nose or cheeks.

10 Feb 2022

Novel immune-profiling method offers a powerful alternative to conventional flow cytometry

Flow cytometry is a powerful and complex technology used to count, sort or measure characteristics of cells and to detect biomarkers.

9 Feb 2022

Research reveals a possible strategy to prevent B-cell acute lymphoblastic leukemia

Short-term treatment with the drug ruxolitinib prevents B-cell acute lymphoblastic leukemia (B-ALL) in mice that have a genetic predisposition to the disease.

8 Feb 2022

Northwestern researchers study COVID-19 mechanisms, infection patterns and impact on gender minorities

Northwestern Medicine investigators continue to study the COVID-19 pandemic, from the biological mechanisms of disease and infection patterns to the pandemic's impact on women and sexual and gender minorities.

6 Feb 2022

Global efforts to track COVID-19 variants grossly underreported a probable variant of concern in Nigeria

If the United States ignores COVID-19 in Nigeria, we forgo global genomic surveillance at our own peril, reports a new Northwestern Medicine study published in Nature Communications.

3 Feb 2022

Genome study reveals unexpected heterogeneity of human ribosomal RNA genes

A genome study undertaken by Johns Hopkins Kimmel Cancer Center researchers to look for variants in a gene considered a fundamental building block for microscopic structures that synthesize proteins took a surprising twist.

2 Feb 2022

N gene target failure method effectively detects SARS-CoV-2 Omicron in clinical samples

In a new study, researchers demonstrated that a commercial real-time polymerase chain reaction (RT-PCR) assay rapidly detects the SARS-CoV-2 Omicron variant.

2 Feb 2022

Nanomedicine can be improved with proper and more predictive in vitro assays

Messenger RNA (mRNA) vaccines are a prime example of the promising field of nanomedicine. But progress in the design and application of nanoparticles as efficient delivery vehicles for biopharmaceutics containing nucleic acid or protein drug substances is, unfortunately, remarkably slow.

1 Feb 2022

C-Path and EJP RD collaborate to expand global rare disease research and drug development

Critical Path Institute (C-Path), an independent global nonprofit organization, and the European Joint Programme on Rare Diseases (EJP RD), an initiative that has received funding from the European Union's Horizon 2020 research and innovation programme, have announced a collaboration to advance technologies and methodologies that are fit for regulatory purposes to further global rare disease research and drug development.

1 Feb 2022

Researchers identify genetic cause of rare interstitial lung disease in a young child

New research from Washington University School of Medicine in St. Louis has solved the medical mystery of why a 2-year-old child — seemingly healthy at birth — succumbed to an undiagnosed, rare illness.

31 Jan 2022

Study identifies drugs that could help combat mortality in patients with COVID-19

Inflammation is a defense mechanism of the body to fight pathogens. However, when it is widespread and excessive, it can aggravate the pathology and even cause death.

31 Jan 2022

Binding and conformational properties of the SARS-CoV spike protein and hACE2 complex

A new paper in the journal Molecules describes this in molecular terms, comparing SARS-CoV-2 with an earlier highly pathogenic coronavirus, SARS-CoV.

31 Jan 2022

Evidence on intra-host recombination of SARS-CoV-2 during superinfection by Alpha and Epsilon variants in USA

A new study captured an instance of SARS-CoV-2 superinfection in an individual, simultaneously infected by two SARS-CoV-2 variants, Alpha and Epsilon during the second COVID-19 wave in New York City in early 2021.

28 Jan 2022

New atlas characterizes immune cells that play a role in hemorrhagic stroke

In work that will enhance the study of such disparate diseases as stroke and dementia, researchers at UC San Francisco have catalogued all the cells that form the blood vessels of the human brain, along with their locations and the genes transcribed in each.

28 Jan 2022

Updated analysis helps clarify the relationship between alcohol consumption and epilepsy

Epilepsy, a common neurological disorder associated with stigma, psychiatric comorbidities, and rising healthcare costs, affects approximately 50 million people globally. A common risk factor associated with the development of epilepsy and seizures is alcohol consumption.

28 Jan 2022

ERGA aims to provide genomic data to inform research about Europe's biodiversity

To provide important genomic data to inform research about Europe's biodiversity, scientists from 48 different countries initiated the "European Reference Genome Atlas" (ERGA) in 2021.

28 Jan 2022

Cross-recognition of SARS-CoV-2 vaccine-elicited T cell responses among different variants

In a new study, researchers evaluated SARS-CoV-2 vaccination-induced T cell responses cross-recognition among the early and novel SARS-CoV-2 variants.

26 Jan 2022

Bioinformatics News and Research

Further Reading

New METPlatform allows researchers to test drugs for possible use in brain metastases

Study helps understand actionable genetic variation affecting drugs in the Middle East population

New DisCo method allows scRNA-seq to efficiently process samples with fewer cells

Artificial intelligence uses facial features to better diagnose rare genetic diseases

Novel immune-profiling method offers a powerful alternative to conventional flow cytometry

Research reveals a possible strategy to prevent B-cell acute lymphoblastic leukemia

Northwestern researchers study COVID-19 mechanisms, infection patterns and impact on gender minorities

Global efforts to track COVID-19 variants grossly underreported a probable variant of concern in Nigeria

Genome study reveals unexpected heterogeneity of human ribosomal RNA genes

N gene target failure method effectively detects SARS-CoV-2 Omicron in clinical samples

Nanomedicine can be improved with proper and more predictive in vitro assays

C-Path and EJP RD collaborate to expand global rare disease research and drug development

Researchers identify genetic cause of rare interstitial lung disease in a young child

Study identifies drugs that could help combat mortality in patients with COVID-19

Binding and conformational properties of the SARS-CoV spike protein and hACE2 complex

Evidence on intra-host recombination of SARS-CoV-2 during superinfection by Alpha and Epsilon variants in USA

New atlas characterizes immune cells that play a role in hemorrhagic stroke

Updated analysis helps clarify the relationship between alcohol consumption and epilepsy

ERGA aims to provide genomic data to inform research about Europe's biodiversity

Cross-recognition of SARS-CoV-2 vaccine-elicited T cell responses among different variants

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