Neurodegenerative Diseases News and Research

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Thinning brain tissue predicts dementia up to a decade before symptoms

A ribbon of brain tissue called cortical gray matter grows thinner in people who go on to develop dementia, and this appears to be an accurate biomarker of the disease five to 10 years before symptoms appear, researchers from The University of Texas Health Science Center at San Antonio (also called UT Health San Antonio) reported.

22 Jan 2024

Discovery of toxic and protective short RNAs associated with Alzheimer's disease and superior memory capacity

Researchers explored how Death Induced by Survival gene Elimination through the analysis of RNA-induced silencing complex-bound short RNAs in Alzheimer's disease models influences neuronal survival and correlates with neurotoxicity in AD.

22 Jan 2024

The Mediterranean Diet may be able to improve your sleep

Researchers review the associations between following a Mediterranean diet and sleep quality.

22 Jan 2024

Short strands of toxic RNAs contribute to brain cell death and DNA damage in Alzheimer's

Alzheimer's disease, which is expected to have affected about 6.7 million patients in the U.S. in 2023, results in a substantial loss of brain cells.

18 Jan 2024

ALS progression linked to mitochondria-associated membrane-ER disconnection

Researchers at Nagoya University in Japan have discovered a relationship between the progression of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and the disruption of mitochondria-associated membranes (MAM), the contact point between the mitochondria and the endoplasmic reticulum (ER) of the cell.

17 Jan 2024

Ancient DNA traces multiple sclerosis origins to 5,000-year-old migrations

Researchers create the world's largest ancient human gene bank, linking genes to multiple sclerosis risk and tracing its origins to migrations 5,000 years ago.

13 Jan 2024

Research reveals the function of a little-understood junction between brain cells

New research from Oregon Health & Science University for the first time reveals the function of a little-understood junction between cells in the brain that could have important treatment implications for conditions ranging from multiple sclerosis to Alzheimer's disease, to a type of brain cancer known as glioma.

12 Jan 2024

Protein linked to neurodegeneration turns out to be crucial for healthy brain function

Researchers have discovered that a protein called phosphorylated α-synuclein, which is associated with several neurodegenerative diseases such as Parkinson's disease and Lewy body dementia, is also involved in the normal processes of how neurons communicate with each other in a healthy brain.

9 Jan 2024

Infammasomes provide a therapeutic target against human diseases

The structure of inflammasomes and their role in diseases.

9 Jan 2024

New test detects Parkinson's disease before symptoms appear

In the development of Parkinson's disease (PD), the changes that will lead to neurodegeneration take place in the brain long before patients show any symptoms.

8 Jan 2024

Early-acting autophagy genes extend lifespan through alternative "garbage disposal" pathway in neurons

Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. In the January 4th issue of Nature Aging, it was noted that scientists from the Buck Institute, Sanford Burnham Prebys and Rutgers University have uncovered possible novel functions for various autophagy genes, which may control different forms of disposal including misfolded proteins - and ultimately affect aging.

4 Jan 2024

PharmaKure granted MHRA Clinical Trial Authorisation (CTA) for PK051 for the treatment of mild cognitive impairment due to Alzheimer’s Disease

Clinical Trial Authorisation application granted for combined drug PK051 targeting amyloid deposits associated with Alzheimer’s Disease.

From PharmaKure 4 Jan 2024

Natural compounds show promise in modulating heme breakdown, offering new therapeutic avenues

Study explores the impact of natural compounds on bilirubin production and heme catabolic pathway modulation, highlighting their potential in treating neurodegenerative and cardiovascular diseases.

3 Jan 2024

Brain's immune cells may be a key target for preventing cognitive deficits after radiation exposure

Researchers at the Del Monte Institute for Neuroscience at the University of Rochester find that microglia - the brain's immune cells - can trigger cognitive deficits after radiation exposure and may be a key target for preventing these symptoms.

3 Jan 2024

AI Integration in the Fight Against Age-Related Macular Degeneration

In this interview, Wen Hwa Lee, CEO, and Chief Scientist at Action Against Age-Related Macular Degeneration (AAAMD), offers an enlightening perspective on merging AI with ophthalmology to forge new paths in healthcare and drug discovery.

From ELRIG (UK) Ltd. 3 Jan 2024

Football linked to more brain damage beyond white matter marks

Signs of injury to the brain's white matter called white matter hyperintensities, as seen on brain scans, may be tied more strongly to vascular risk factors, brain shrinkage, and other markers of dementia in former tackle football players than in those who did not play football, according to a study published in the December 20, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.

20 Dec 2023

NEMO protein's crucial role in Parkinson's defense revealed

Researchers have identified a mechanism that promotes the breakdown of harmful protein deposits. If it malfunctions, it can lead to Parkinson’s disease.

19 Dec 2023

PharmaKure and Universiti Teknologi MARA (UiTM) announce partnership to advance research in Alzheimer’s Disease diagnosis

Research partnership aims to build strong pharma and academic collaborations in sharing data and clinical samples to develop biomarker-based diagnostics for Alzheimer’s Disease.

12 Dec 2023

Research uncovers potential treatment target for rare, genetic type of epilepsy

Researchers at the Francis Crick Institute, UCL and MSD have identified a potential treatment target for a genetic type of epilepsy.

11 Dec 2023

Study provides a better understanding of how the brain responds to injuries

A new study published in Proceedings of the National Academy of Sciences Nexus provides a better understanding of how the brain responds to injuries.

11 Dec 2023

Neurodegenerative Diseases News and Research

Thinning brain tissue predicts dementia up to a decade before symptoms

Discovery of toxic and protective short RNAs associated with Alzheimer's disease and superior memory capacity

The Mediterranean Diet may be able to improve your sleep

Short strands of toxic RNAs contribute to brain cell death and DNA damage in Alzheimer's

ALS progression linked to mitochondria-associated membrane-ER disconnection

Ancient DNA traces multiple sclerosis origins to 5,000-year-old migrations

Research reveals the function of a little-understood junction between brain cells

Protein linked to neurodegeneration turns out to be crucial for healthy brain function

Infammasomes provide a therapeutic target against human diseases

New test detects Parkinson's disease before symptoms appear

Early-acting autophagy genes extend lifespan through alternative "garbage disposal" pathway in neurons

PharmaKure granted MHRA Clinical Trial Authorisation (CTA) for PK051 for the treatment of mild cognitive impairment due to Alzheimer’s Disease

Natural compounds show promise in modulating heme breakdown, offering new therapeutic avenues

Brain's immune cells may be a key target for preventing cognitive deficits after radiation exposure

AI Integration in the Fight Against Age-Related Macular Degeneration

Football linked to more brain damage beyond white matter marks

NEMO protein's crucial role in Parkinson's defense revealed

PharmaKure and Universiti Teknologi MARA (UiTM) announce partnership to advance research in Alzheimer’s Disease diagnosis

Research uncovers potential treatment target for rare, genetic type of epilepsy

Study provides a better understanding of how the brain responds to injuries

eBook: Using iPSCs models for human disease research and drug discovery eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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