Small Molecules News and Research

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Researchers explore new immune checkpoint for head and neck cancer

A checkpoint may delay travelers but it can help give cancer free rein by suppressing the natural immune response that should destroy it, researchers say.

25 Jun 2019

Metabolomics may be key to identifying diabetes-related kidney disease

Metabolomics, the study of small molecules the body produces during metabolism (metabolites) may be a future key to identifying diabetes-related kidney disease.

24 Jun 2019

New chief medical officer appointed for Cancer Research UK’s Centre for Drug Development

Professor Peter Johnson will be the new chief medical officer for Cancer Research UK’s Centre for Drug Development, it was announced today (Tuesday).

19 Jun 2019

Scientists develop new class of drugs to treat hereditary kidney disease

Scientists from the University of Sheffield are part of an international collaboration to develop a new class of drugs to treat a common genetic kidney disease which is a major cause of kidney failure.

18 Jun 2019

Researchers examine transport mechanism of bacterial membrane protein

An international research team has investigated the transport mechanism of a bacterial membrane protein using an artificially produced antibody fragment.

17 Jun 2019

Super-Resolution Raman Imaging with Plasmonic Substrates

Renee Frontiera discusses the development of a super-resolution Raman microscope that could one day supersede fluorescence-based super-resolution microscopes.

From Pittcon 14 Jun 2019

Research identifies new target that may help develop new treatments for common STD

Research led by Ashok Aiyar, PhD, Associate Professor of Microbiology, Immunology and Parasitology at LSU Health New Orleans School of Medicine, has identified a target that may lead to the development of new treatments for the most common sexually transmitted infection in the US.

31 May 2019

Study reveals how air pollution affects the human body at the metabolite level

A new University at Buffalo study based on levels before, during and after the Beijing Olympics reveals how air pollution affects the human body at the level of metabolites.

30 May 2019

Research could lead to new treatments for people with autoimmune disorders

The immune system is programmed to rid the body of biological bad guys--like viruses and dangerous bacteria--but its precision isn't guaranteed. In the tens of millions of Americans suffering from autoimmune diseases, the system mistakes normal cells for malicious invaders, prompting the body to engage in self-destructive behavior.

29 May 2019

Study reveals how genetic message to produce healthy heart tissue is altered during stress, aging

Researchers at the Fralin Biomedical Research Institute at Virginia Tech Carilion have revealed how a genetic message to produce healthy heart tissue is altered in the body during stress and aging to contribute to sudden cardiac death.

29 May 2019

Researchers discover new hybrid molecules that could act as anti-cancer agents

Researchers from NYU Abu Dhabi's chemistry program and colleagues from the University's biology program have developed and studied the biological activity of five new, metal-organic hybrid knotted molecules, termed metal-organic trefoil knots.

23 May 2019

Research uncovers potential breakthrough in the understanding of tumor dormancy

Scientists at VCU Massey Cancer Center may have uncovered a primary method through which cancer cells exist undetected in an organism and received more than $1 million to investigate the potential for novel therapeutics that target and destroy cells in a specific state of tumor dormancy.

22 May 2019

Study helps explain why lack of sleep is bad for the heart

In recent years, numerous studies have shown that people who don't get enough sleep are at greater risk of stroke and heart attack.

21 May 2019

Scientists discover mechanism responsible for chronic inflammation in MS

Multiple sclerosis is an autoimmune disease. The defense system that usually protects patients from external aggression turns on its own cells and attacks them for reasons that are not yet known.

11 May 2019

Common foods linked to arterial stiffening in new metabolomics study

Researchers have identified several lifestyle factors that could cause arteries to stiffen and increase the risk of heart disease, two of which were peptides found in common foods.

7 May 2019

Discovery of small-molecule inhibitors could enable precise control over CRISPR-Cas9 genome editing

The discovery of the first small-molecule inhibitors of the Streptococcus pyogenes Cas9 (SpCas9) protein could enable more precise control over CRISPR-Cas9-based genome editing, researchers report May 2 in the journal Cell.

3 May 2019

Novel chemical probe enables live imaging of brain immune cells

Researchers in South Korea and Singapore have, for the first time, developed a chemical probe that enables live-imaging of a type of immune cells in the brain, known as microglia, in a live animal brain.

3 May 2019

Scientists develop small fluorophores for tracking metabolites in living cells

Living cells can react to disturbances with a changed metabolism, but direct observation of trafficking metabolites in live cells is difficult.

30 Apr 2019

Uncovering the Structure of HIV Integrase to Inform Drug Discovery

In this interview Dr Kushol Gupta, Research Assistant Professor in the Department of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania talks to News-Medical and Life Sciences about the importance of light scattering techniques for investigating structure and mechanism of action in his ongoing research into HIV integrase and the development of HIV therapeutics.

From Waters | Wyatt Technology 24 Apr 2019

Reviving the heart's regenerative capacities using microRNAs

Once the heart is fully formed, the cells that make up heart muscle, known as cardiomyocytes, have very limited ability to reproduce themselves. After a heart attack, cardiomyocytes die off; unable to make new ones, the heart instead forms scar tissue. Over time, this can set people up for heart failure.

23 Apr 2019