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Cannabidiol shown to extend lifespan and improve symptoms in Leigh syndrome models

A study led by the UAB Institut de Neurociències and published in the journal Nature Communications demonstrates in animal models how daily administration of cannabidiol (CBD), a substance obtained from the cannabis plant, extends lifespan and improves symptoms associated with Leigh syndrome.

6 Sep 2024

New DELIVER guidelines aim to accelerate nanomedicine development

They're tiny drug-delivery systems 1000 times smaller than a human hair, but while nanomedicines have long been hailed as the future for treating debilitating and life-threatening diseases, their journey from lab to patient has many challenges.

6 Sep 2024

Scientists advance type 1 diabetes treatment with cutting-edge stem cell and gene editing technologies

Researchers review significant advancements and ongoing challenges in cell replacement therapies for type 1 diabetes, highlighting innovative approaches in stem cell-derived islets and immune protection strategies.

5 Sep 2024

Evaluating underwater endoscopic mucosal resection for gastrointestinal neuroendocrine tumors

Neuroendocrine tumors (NETs) of the gastrointestinal (GI) tract are a rare and heterogeneous group of malignancies arising from the neuroendocrine cell system.

4 Sep 2024

Discovery of cellular process could impact the understanding of cancer and aging

Researchers at UC Merced used fruit flies to uncover a cellular process common to many organisms that could dramatically impact the understanding of cancer and aging.

3 Sep 2024

Clonal hematopoiesis identified as new risk factor for atherosclerosis

To the known risk factors for cardiovascular disease - high blood pressure, high cholesterol, diabetes, overweight and obesity, smoking, and physical inactivity - a new one has to be added: clonal hematopoiesis.

30 Aug 2024

Northwestern NUCATS Institute secures $55 million NIH grant for health care advancements

The Northwestern University Clinical and Translational Sciences (NUCATS) Institute has received $55 million in National Institutes of Health (NIH) funding to accelerate the development, evaluation and implementation of improved health care interventions.

29 Aug 2024

NSF funds UCSB-led Biofoundry to revolutionize biotechnology with unexplored microbes

This week, the National Science Foundation announced the award of a six-year, $22M grant to UC Santa Barbara under its biofoundries program for the establishment of the BioFoundry for Extreme and Exceptional Fungi, Archaea and Bacteria (ExFAB), a collaboration led by UC Santa Barbara (UCSB), together with UC Riverside (UCR), and Cal Poly Pomona (CPP). ExFAB establishes the nation's first biofoundry that focuses on largely untapped and unexplored extreme microbes. UCSB's award is one of only five grants made under NSF's BioFoundry program during this funding cycle, which awarded a total of $75M to the five selected universities.

29 Aug 2024

Understanding the mechanisms of cardiac fibrosis

The article explores the role of the m6A reader YTHDF1 in cardiac fibrosis, a condition characterized by the excessive accumulation of extracellular matrix proteins, leading to the stiffening of the heart and impaired function. Cardiac fibrosis is a common pathological process in various cardiovascular diseases, including hypertension, myocardial infarction, and heart failure.

29 Aug 2024

New biomedical device offers hope for patients with chronic pain

Pain is a necessary biological signal, but a variety of conditions can cause those signals to go awry. For people with chronic pain, the root is often faulty signals emerging deep within the brain, giving false alarms about a wound that has since healed, a limb that has since been amputated, or other intricate, hard-to-explain scenarios.

28 Aug 2024

AHN myLab® 96 well plate centrifuge

With the age of single-tube PCR reactions fast being eclipsed by microplate-based PCR setups, scientists need tools that are equal to the task. The AHN myLab® PCR plate spinner is designed to offer dependable performance for all PCR plate applications.

From AHN Biotechnologie GmbH 28 Aug 2024

Self-assembling heart stimulator can correct heart arrhythmia in emergency situations

By injecting a solution of nanoparticles around the heart, a temporary heart stimulator self-assembles, which can correct heart arrhythmia in emergency situations with the help of an external power source.

27 Aug 2024

Study reveals metabolic switch crucial for memory T cell formation and cancer immunity

A Ludwig Cancer Research study has identified a metabolic switch in the immune system's T cells that is essential to the generation of memory T cells - which confer lasting immunity to previously encountered pathogens - and a T cell subtype found in tumors that drives anti-tumor responses during immunotherapy.

23 Aug 2024

Advances in endoscopic treatment for inflammatory bowel disease complications

Inflammatory bowel diseases (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions affecting the gastrointestinal tract.

23 Aug 2024

Rising IBD incidence highlights need for non-invasive biomarkers in diagnosis

The global burden of inflammatory bowel diseases (IBD), primarily Crohn's disease (CD) and ulcerative colitis (UC), continues to rise. Recent data show incidence rates of up to 17.8 cases per 100,000 person-years for CD and even higher for UC, reaching 28.4 per 100,000 person-years. These diseases primarily affect older populations and vary geographically, with higher prevalence rates in highly developed countries.

23 Aug 2024

Translation News and Research

Cannabidiol shown to extend lifespan and improve symptoms in Leigh syndrome models

New DELIVER guidelines aim to accelerate nanomedicine development

Scientists advance type 1 diabetes treatment with cutting-edge stem cell and gene editing technologies

Evaluating underwater endoscopic mucosal resection for gastrointestinal neuroendocrine tumors

Discovery of cellular process could impact the understanding of cancer and aging

Clonal hematopoiesis identified as new risk factor for atherosclerosis

Northwestern NUCATS Institute secures $55 million NIH grant for health care advancements

NSF funds UCSB-led Biofoundry to revolutionize biotechnology with unexplored microbes

Understanding the mechanisms of cardiac fibrosis

New biomedical device offers hope for patients with chronic pain

AHN myLab® 96 well plate centrifuge

Self-assembling heart stimulator can correct heart arrhythmia in emergency situations

Study reveals metabolic switch crucial for memory T cell formation and cancer immunity

Advances in endoscopic treatment for inflammatory bowel disease complications

Rising IBD incidence highlights need for non-invasive biomarkers in diagnosis

Long-term low-dose cannabis reverses brain aging in mice

Understanding gluten's role in autoimmunity and inflammation

Leukemia cells depend on P-bodies for growth and survival

Fasting and ketogenic diet reveal new vulnerability of pancreatic tumors to existing cancer drug

Brain scans can detect consciousness in some unresponsive patients

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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