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New drug could prevent Alzheimer's by modulating key enzyme involved in amyloid plaque formation

Amyloid plaques are pathological hallmarks of Alzheimer's disease (AD) -- clumps of misfolded proteins that accumulate in the brain, disrupting and killing neurons and resulting in the progressive cognitive impairment that is characteristic of the widespread neurological disorder.

2 Mar 2021

Study shows how SARS-CoV-2 affects cytokines compared to other respiratory viruses

Respiratory viruses such as SARS-CoV-2 (causing COVID-19) can often catalyze an overactive immune response that leads to a life-threatening cycle, known as a cytokine storm.

2 Mar 2021

Study shows asthma mediator IL-13 prevents SARS-CoV-2 infection

In a paper published on the bioRxiv preprint server, researchers reported the results on whether IL-13 expression in asthma patients reduces their susceptibility to SARS-CoV-2 infection.

1 Mar 2021

Scientists establish infection models for SARS-CoV-2 UK & South African variants

New research suggests Syrian golden hamsters could be a potentially useful preclinical model for testing vaccine immunity against the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.17 and B.1.351 variant.

1 Mar 2021

Study: Repurposed arthritis drug did not improve outcomes of patients with severe COVID-19 pneumonia

In a study published online February 25, 2021 in The New England Journal of Medicine, a repurposed drug used to treat arthritis did not significantly improve the outcomes of patients with severe COVID-19 pneumonia.

1 Mar 2021

Study: Highly efficient and balanced immune response key to avoiding COVID-19 symptoms

By analyzing blood samples from individuals infected with SARS-CoV-2, researchers in Singapore have begun to unpack the different responses by the body's T cells that determine whether or not an individual develops COVID-19.

1 Mar 2021

New paper discusses how smoking may affect risk for COVID-19

A new paper published online in the Annals of the American Thoracic Society discusses how smoking may affect risk for COVID-19 and the types of research that are needed to better understand the link between smoking and COVID-19 risk.

1 Mar 2021

Researchers to conduct large meta-analysis of fetomaternal complications in COVID-19

A new preprint on the medRxiv* server describes the protocol written for a study that aims to perform a systematic analysis of all the data available on the effect of this syndrome on pregnancy.

1 Mar 2021

New calculators could enable clinicians to better stratify risk in COVID-infected patients

Two novel calculators for predicting which patients admitted to the hospital with COVID-19 are at greatest risk of requiring mechanical ventilation or of in-hospital death have been developed and validated by Massachusetts General Hospital (MGH).

27 Feb 2021

Newly identified genes increase risk of obesity and also protect against this disease

People living with obesity tend to have unhealthy glucose and lipid levels in their blood, as well as high blood pressure.

27 Feb 2021

Atherosclerosis can speed up the development of clonal hematopoiesis

Billions of peripheral white blood cells are produced every day by the regular divisions of hematopoietic stem cells and their descendants in the bone marrow.

27 Feb 2021

Biomarkers in the blood can predict severe outcomes in COVID-19 patients

When patients with COVID-19 arrive in emergency rooms, there are relatively few ways for doctors to predict which ones are more likely to become critically ill and require intensive care and which ones are more likely to enjoy a quick recovery.

26 Feb 2021

Statin use associated with reduction in mortality of patients with severe COVID-19

People who took statins to lower cholesterol were approximately 50% less likely to die if hospitalized for COVID-19, a study by physicians at Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian has found.

26 Feb 2021

Well-known spasmolytic drug can suppress inflammatory response in astrocytes

Biologists from RUDN University confirmed that a well-known spasmolytic drug called hymecromone can suppress the inflammatory response in astrocytes, important glial cells of the central nervous system.

26 Feb 2021

NLRP3 inflammasome inhibitors may help treat early COVID-19, says study

A new study by researchers in the U.S. further supports the hypothesis that the unregulated release of inflammatory cytokines is responsible for the local and systemic inflammation that is associated with multi-organ damage and death in severe COVID-19.

26 Feb 2021

Microbes could predict fatal outcomes in ventilated COVID-19 patients

The study "Microbial signatures in the lower airways of mechanically ventilated COVID19 patients associated with poor clinical outcome" is available as a preprint on the medRxiv* server, while the article undergoes peer review.

25 Feb 2021

Maternal diet may enhance immune systems of premature infants, study shows

Medical researchers have long understood that a pregnant mother's diet has a profound impact on her developing fetus's immune system and that babies -- especially those born prematurely -- who are fed breast milk have a more robust ability to fight disease, suggesting that even after childbirth, a mother's diet matters.

25 Feb 2021

New biomarker discovery could help guide treatment of active sarcoidosis

Low blood levels of immune cells called lymphocytes, in combination with higher levels of inflammation on PET/CT scans, are indicators of active sarcoidosis -- an inflammatory disease that attacks multiple organs, particularly the lungs and lymph nodes -- which disproportionately affects African Americans.

25 Feb 2021

Repetitive compression of limbs may improve recovery from the most deadly stroke

Scientists want to know more about how an inexpensive, low-risk treatment may improve recovery from the most deadly type of stroke.

25 Feb 2021

SNX-5422 could make an effective COVID-19 prophylactic, says study

SNX-5422 is a heat shock protein 90 (Hsp90) inhibitor currently undergoing clinical trials as a cancer therapeutic. A recent study examines the applicability of repurposing the drug towards severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication inhibition.

25 Feb 2021

Inflammation News and Research

New drug could prevent Alzheimer's by modulating key enzyme involved in amyloid plaque formation

Study shows how SARS-CoV-2 affects cytokines compared to other respiratory viruses

Study shows asthma mediator IL-13 prevents SARS-CoV-2 infection

Scientists establish infection models for SARS-CoV-2 UK & South African variants

Study: Repurposed arthritis drug did not improve outcomes of patients with severe COVID-19 pneumonia

Study: Highly efficient and balanced immune response key to avoiding COVID-19 symptoms

New paper discusses how smoking may affect risk for COVID-19

Researchers to conduct large meta-analysis of fetomaternal complications in COVID-19

New calculators could enable clinicians to better stratify risk in COVID-infected patients

Newly identified genes increase risk of obesity and also protect against this disease

Atherosclerosis can speed up the development of clonal hematopoiesis

Biomarkers in the blood can predict severe outcomes in COVID-19 patients

Statin use associated with reduction in mortality of patients with severe COVID-19

Well-known spasmolytic drug can suppress inflammatory response in astrocytes

NLRP3 inflammasome inhibitors may help treat early COVID-19, says study

Microbes could predict fatal outcomes in ventilated COVID-19 patients

Maternal diet may enhance immune systems of premature infants, study shows

New biomarker discovery could help guide treatment of active sarcoidosis

Repetitive compression of limbs may improve recovery from the most deadly stroke

SNX-5422 could make an effective COVID-19 prophylactic, says study

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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