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Vaccinating people over 60 is the most effective way to mitigate COVID-19 mortality

Vaccinating people over 60 is the most effective way to mitigate mortality from COVID-19, a new age-based modeling study suggests.

22 Jan 2021

People who have positive views of aging at 50 live 7.5 years longer

If you believe you are capable of becoming the healthy, engaged person you want to be in old age, you are much more likely to experience that outcome, a recent Oregon State University study shows.

22 Jan 2021

Modified version of CAR T-cell therapy shows promise in targeting neuroblastoma

Chimeric Antigen Receptor T-cell therapy--CAR T--has revolutionized leukemia treatment. Unfortunately, the therapy has not been effective for treating solid tumors including childhood cancers such as neuroblastoma.

22 Jan 2021

Trial results support efficacy of incentivizing vaccine adherence

As the United States struggles to control record-breaking increases in COVID-19 infections and hospitalizations, the roll-out of two approved vaccines offers tremendous hope for saving lives and curbing the pandemic.

22 Jan 2021

New study helps understand molecular profile of tumors in cancer patients

Researchers from the University Hospitals in Zurich and Basel, ETH Zurich, University of Zurich and the pharmaceutical company Roche have set out to improve cancer diagnostics by developing a platform of state-of-the-art molecular biology methods.

21 Jan 2021

Prioritizing older adults for COVID-19 vaccination will save more lives

Vaccinating older adults for COVID-19 first will save substantially more U.S. lives than prioritizing other age groups, and the slower the vaccine rollout and more widespread the virus, the more critical it is to bring them to the front of the line.

21 Jan 2021

New data on impact of spike mutations and B117 UK variant on neutralization by mAbs and sera

A recent paper by British and Dutch scientists, currently available on the bioRxiv* preprint server, shows that the neutralizing activity of monoclonal antibodies can be dramatically reduced by mutations of the SARS-CoV-2 spike glycoprotein – unlike polyclonal antibodies generated after natural infection that remain active regardless of any introduced amino acid changes.

21 Jan 2021

Pfizer-BioNTech vaccine shows reduced neutralization potential against SARS-CoV-2 B.1.1.7 spike variant

Researchers in the UK have conducted a study assessing the efficacy of the Pfizer-BioNTech COVID-19 vaccine BNT162b2 against the new variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

21 Jan 2021

Investigational combo therapy shows promise in treating TP53 mutant MDS and AML patients

Myelodysplastic Syndromes (MDS) and acute myeloid leukemia (AML) are rare hematologic malignancies of the bone marrow.

21 Jan 2021

FDA approves first injectable, complete regimen for HIV-1 infection in adults

The U.S. Food and Drug Administration today approved Cabenuva (cabotegravir and rilpivirine, injectable formulation) as a complete regimen for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults to replace a current antiretroviral regimen in those who are virologically suppressed on a stable antiretroviral regimen with no history of treatment failure and with no known or suspected resistance to either cabotegravir or rilpivirine.

21 Jan 2021

Study shows antidepressant drugs are largely ineffective for back and osteoarthritis pain

Antidepressant drugs are largely ineffective for back and osteoarthritis pain, despite being widely used for these conditions, suggests a review of the evidence published by The BMJ today.

20 Jan 2021

Antidepressants are not effective for treating back pain, osteoarthritis, shows study

Antidepressants are commonly used worldwide to treat pain, however new research from the University of Sydney shows they offer little to no help for people suffering chronic back pain and osteoarthritis and may even cause harm.

20 Jan 2021

Potentially promising therapeutic combination for renal cell carcinoma uncovered

Renal cell carcinoma (RCC) is the most common form of cancer of the kidney. In 2018, there were an estimated 403,000 new cases of RCC and 175,000 deaths due to kidney cancer worldwide.

20 Jan 2021

Automated method tracks cortical origin and initial spread of TAU proteins in Alzheimer’s disease

Researchers have developed an automated method that can track the development of harmful clumps of TAU protein related to Alzheimer's disease in the brain, according to work involving 443 individuals.

20 Jan 2021

Ethacrynic acid, a diuretic drug with potential anti-SARS-CoV-2 activity

A study published recently in the journal Viruses has identified a potent diuretic ethacrynic acid as an efficient inhibitor of the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This drug can be potentially repurposed to treat coronavirus disease 2019 (COVID-19).

20 Jan 2021

Designer DNA agent reduces myeloma stem cell abundance, lowers disease burden in mice

Many patients with multiple myeloma, a type of blood cancer, eventually develop resistance to one treatment after another. That's in part because cancer stem cells drive the disease -- cells that continually self-renew. If a therapy can't completely destroy these malignant stem cells, the cancer is likely to keep coming back.

20 Jan 2021

Putatively immature dendritic cells may induce robust immune responses in young children

A study by Ludwig-Maximilians-Universitaet (LMU) in Munich researchers shows that putatively immature dendritic cells found in young children are able to induce robust immune responses. The results could lead to improved vaccination protocols.

20 Jan 2021

Essential coaching for mothers during COVID-19

Pregnancy and childbirth are especially high-risk periods for mental ill-health. The mobile health program called Essential Coaching for Every Mother (ECEM) was designed to meet the needs of mothers during this critical time, but its introduction was delayed because of the onset of the pandemic.

19 Jan 2021

Mapping antibody reactivity in COVID-19 patients by using multi-coronavirus protein microarray

In an exciting, state-of-the-art study currently available on the medRxiv* preprint server, US researchers created a multi-coronavirus protein microarray containing full-length proteins, peptide libraries, and overlapping protein fragments from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as four other human coronaviruses.

19 Jan 2021

Carbon-based nanomaterials as potential COVID-19 treatments

An international team of researchers says that carbon-based nanomaterials (CBNs) could represent promising new approaches to treating coronavirus disease 2019 (COVID-19) pneumonia that is complicated by a secondary bacterial, viral or fungal infection.

19 Jan 2021

Efficacy News and Research

Vaccinating people over 60 is the most effective way to mitigate COVID-19 mortality

People who have positive views of aging at 50 live 7.5 years longer

Modified version of CAR T-cell therapy shows promise in targeting neuroblastoma

Trial results support efficacy of incentivizing vaccine adherence

New study helps understand molecular profile of tumors in cancer patients

Prioritizing older adults for COVID-19 vaccination will save more lives

New data on impact of spike mutations and B117 UK variant on neutralization by mAbs and sera

Pfizer-BioNTech vaccine shows reduced neutralization potential against SARS-CoV-2 B.1.1.7 spike variant

Investigational combo therapy shows promise in treating TP53 mutant MDS and AML patients

FDA approves first injectable, complete regimen for HIV-1 infection in adults

Study shows antidepressant drugs are largely ineffective for back and osteoarthritis pain

Antidepressants are not effective for treating back pain, osteoarthritis, shows study

Potentially promising therapeutic combination for renal cell carcinoma uncovered

Automated method tracks cortical origin and initial spread of TAU proteins in Alzheimer’s disease

Ethacrynic acid, a diuretic drug with potential anti-SARS-CoV-2 activity

Designer DNA agent reduces myeloma stem cell abundance, lowers disease burden in mice

Putatively immature dendritic cells may induce robust immune responses in young children

Essential coaching for mothers during COVID-19

Mapping antibody reactivity in COVID-19 patients by using multi-coronavirus protein microarray

Carbon-based nanomaterials as potential COVID-19 treatments

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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