Clinical Trial News and Research

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New, more easily administered therapies offer benefits for bleeding and clotting disorders

In three studies being presented today during the 59th American Society of Hematology (ASH) Annual Meeting and Exposition in Atlanta, researchers report remarkable benefits from new, more easily administered therapies for bleeding and clotting disorders.

11 Dec 2017

Pairing immunotherapy drug with chemotherapy proves beneficial for relapsed acute myeloid leukemia

University of North Carolina Lineberger Comprehensive Cancer Center researchers report that pairing an immunotherapy drug with chemotherapy proved beneficial for some patients with acute myeloid leukemia whose disease did not respond to standard treatment or had relapsed.

11 Dec 2017

Combination of chemotherapy and targeted drug improves response in younger CLL patients

Among younger patients newly diagnosed with chronic lymphocytic leukemia (CLL), treatment with a combination of chemotherapy and a molecularly targeted drug significantly improves response over what is typically seen with chemotherapy alone, according to an investigator-initiated multi-center phase II clinical trial.

11 Dec 2017

Mayo Clinic researchers find emojis to be helpful in assessing patients' quality of life

In findings presented to the American Society of Hematology, Mayo Clinic researchers found that using emojis instead of traditional emotional scales were helpful in assessing patients' physical, emotional and overall quality of life.

11 Dec 2017

St. Jude gene therapy offers hope for infants with 'bubble boy' disease

Early evidence suggests that gene therapy developed at St. Jude Children's Research Hospital will lead to broad protection for infants with the devastating immune disorder X-linked severe combined immunodeficiency disorder.

11 Dec 2017

New genetic model identified for predicting outcomes in patients with primary myelofibrosis

A group of investigators from Mayo Clinic and multiple academic research centers in Italy have identified a genetic model for predicting outcomes in patients with primary myelofibrosis who are 70 years or younger and candidates for stem cell transplant to treat their disease.

11 Dec 2017

Drug improves disease-free, overall survival after hematopoietic stem cell transplants

Results from a phase 2 clinical trial, presented by Seattle Children's Research Institute at the 59th American Society of Hematology Annual Meeting, show that the drug Abatacept (Orencia) nearly eliminated life-threatening severe acute graft-versus-host disease (GvHD) in patients receiving hematopoietic stem cell transplants.

11 Dec 2017

Bi-annual MRI beats mammograms in detecting breast cancer among women with genetic risk

Intensive surveillance including a dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) exam every six months was far more effective in detecting breast cancer in younger women with a high-risk genetic profile than an annual mammogram, according to a research team based at the University of Chicago Medicine and the University of Washington, Seattle.

11 Dec 2017

Two immunotherapy approaches for multiple myeloma show hope

Researchers from the University of Pennsylvania's Abramson Cancer Center have developed two experimental immunotherapy methods that include one chimeric antigen receptor (CAR) T cell therapy for the treatment of multiple myeloma patients who were not responding to other treatments.

11 Dec 2017

Anti-impotence drug found to be ineffective at improving outcomes for IUGR pregnancies

A University of Liverpool led international clinical trial has found an anti-impotence drug to be ineffective at improving outcomes for pregnancies complicated by fetal growth restriction.

8 Dec 2017

Study finds mechanism of resistance to checkpoint inhibitors and way to reverse it

Researchers have discovered a mechanism of resistance to checkpoint inhibitors and how to reverse it. The biomarker results from the IMvigor210 study are reported at the ESMO Immuno Oncology Congress 2017.

8 Dec 2017

PARP inhibitor can be new treatment option for patients with metastatic breast cancer, BRCA mutations

In a randomized, Phase III trial led by researchers at The University of Texas MD Anderson Cancer Center, the PARP inhibitor talazoparib extended progression-free survival (PFS) and improved quality-of-life measures over available chemotherapies for patients with metastatic HER2-negative breast cancer and mutations in the BRCA1/2 genes.

8 Dec 2017

Gene therapy shows promising effect against blood clots, study states

A new study conducted in the Children's Hospital Of Philadelphia (CHOP) reported positive results in a phase 1/2 clinical trial for the inherited bleeding disorder hemophilia B.

8 Dec 2017

Powerful clot-busting drugs reserved for selected patients with deep vein thrombosis

Not all patients with blood clots in their legs – a condition known as deep vein thrombosis – need to receive powerful but risky clot-busting drugs, according to results of a large-scale, multicenter clinical trial.

7 Dec 2017

Clinical study uses genetic testing to match AML patients with new therapies

A clinical trial using genetic testing to match acute myeloid leukemia (AML) patients with new therapies is now open at the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center

6 Dec 2017

Intensive weight management program can help people with type 2 diabetes achieve remission

Type 2 diabetes can be reversed following an intensive weight management program, according a randomized trial in adults who have had the condition for up to 6 years, published in The Lancet.

6 Dec 2017

Immune-boosting drug combination may hold promise for treating ovarian cancer

Johns Hopkins Kimmel Cancer Center researchers demonstrated that mice with ovarian cancer that received drugs to reactivate dormant genes along with other drugs that activate the immune system had a greater reduction of tumor burden and significantly longer survival than those that received any of the drugs alone.

5 Dec 2017

Investigational ZPIV vaccine found to be safe and immunogenic in trial participants

The investigational Zika purified inactivated virus (ZPIV) vaccine was well-tolerated and induced an immune response in participants, according to initial results from three Phase 1 clinical trials.

5 Dec 2017

New treatment aims to target abnormally shaped protein in deadly childhood brain cancer

Children with an extremely deadly form of brain cancer might benefit from a new treatment that aims to direct an immune response against an abnormally shaped protein found exclusively on cancer cells, according to a new study led by UC San Francisco researchers.

4 Dec 2017

Placenta capsules offer little to no benefit for new mothers, study shows

A groundbreaking study by UNLV researchers shows that taking placenta capsules has little to no effect on postpartum mood, maternal bonding, or fatigue, when compared to a placebo.

1 Dec 2017

Clinical Trial News and Research

New, more easily administered therapies offer benefits for bleeding and clotting disorders

Pairing immunotherapy drug with chemotherapy proves beneficial for relapsed acute myeloid leukemia

Combination of chemotherapy and targeted drug improves response in younger CLL patients

Mayo Clinic researchers find emojis to be helpful in assessing patients' quality of life

St. Jude gene therapy offers hope for infants with 'bubble boy' disease

New genetic model identified for predicting outcomes in patients with primary myelofibrosis

Drug improves disease-free, overall survival after hematopoietic stem cell transplants

Bi-annual MRI beats mammograms in detecting breast cancer among women with genetic risk

Two immunotherapy approaches for multiple myeloma show hope

Anti-impotence drug found to be ineffective at improving outcomes for IUGR pregnancies

Study finds mechanism of resistance to checkpoint inhibitors and way to reverse it

PARP inhibitor can be new treatment option for patients with metastatic breast cancer, BRCA mutations

Gene therapy shows promising effect against blood clots, study states

Powerful clot-busting drugs reserved for selected patients with deep vein thrombosis

Clinical study uses genetic testing to match AML patients with new therapies

Intensive weight management program can help people with type 2 diabetes achieve remission

Immune-boosting drug combination may hold promise for treating ovarian cancer

Investigational ZPIV vaccine found to be safe and immunogenic in trial participants

New treatment aims to target abnormally shaped protein in deadly childhood brain cancer

Placenta capsules offer little to no benefit for new mothers, study shows

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