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Gut bacteria can influence how cancer responds to immunotherapy

Bacteria that live in the human digestive tract can influence how cancer responds to immunotherapy, opening a new avenue for research to improve treatment, a team led by researchers at The University of Texas MD Anderson Cancer Center reports in the journal Science.

2 Nov 2017

CRFA better than steroid injection for managing pain from knee osteoarthritis

For patients with osteoarthritis of the knee, a minimally invasive procedure called cooled radiofrequency ablation provides better pain reduction and functional improvement compared to steroid injection of the knee, concludes a study in Regional Anesthesia & Pain Medicine, published by Wolters Kluwer.

2 Nov 2017

Preclinical studies show effectiveness of targeted therapy for glioblastoma

The targeted therapy onalespib has shown effectiveness in preclinical studies of glioblastoma by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

2 Nov 2017

First-of-its-kind nonsynthetic, decellularized graft one step closer to clinical trials

Researchers at the University of Minnesota have created a new lab-grown blood vessel replacement that is composed completely of biological materials, but surprisingly doesn't contain any living cells at implantation. The vessel, that could be used as an "off the shelf" graft for kidney dialysis patients, performed well in a recent study with nonhuman primates.

1 Nov 2017

Poor white matter health may contribute to persistent musculoskeletal pain in Gulf War veterans

A study from the William S. Middleton Memorial Veterans Hospital in Madison, Wisconsin, has shown that structural damage in the white matter of the brain may be linked to chronic musculoskeletal pain in Gulf War veterans.

1 Nov 2017

PARP inhibitors may have efficacy in selected TNBC patients outside of germline BRCA mutation

The investigational PARP inhibitor talazoparib caused regression of patient-derived xenografts (PDXs) of triple-negative breast cancers (TNBC) that had BRCA mutations and also those that did not have BRCA mutations but had other alterations in DNA damage-repair pathways.

1 Nov 2017

Cleveland Clinic researchers win grants to study ethical issues involving brain surgery

The NIH BRAIN Initiative has awarded two Cleveland Clinic researchers grants to study ethical issues involving brain surgery, as part of the first neuroethics grants awarded by the initiative.

31 Oct 2017

GHIT Fund announces US$16.7 million to support development of new drugs, vaccines and diagnostics

The Global Health Innovative Technology Fund, a unique Japanese public-private partnership formed to battle infectious diseases around the globe, today announced US$16.7 million to support development of new compounds for fighting malaria and tuberculosis, a leishmaniasis vaccine and drug, and a treatment for a long-ignored flesh-eating infection.

31 Oct 2017

New treatment reduces disease burden in patients with rare dermatologic condition

A new treatment for a rare and often incurable condition called dermatomyositis (DM) reduced the severity of the disease in patients whose DM was resistant to other therapies.

31 Oct 2017

SU2C and its collaborators announce four teams to intercept cancer at earliest stages

Stand Up To Cancer, joined by the Lustgarten Foundation for Pancreatic Cancer Research, LUNGevity, and the American Lung Association, announced today four teams of top researchers who will carry out an attack on cancers of the lung and pancreas using a radical new approach of “interception” of cancers at very early stages, when they can be more successfully treated.

31 Oct 2017

Researchers uncover surprising immune cell activity that may explain limitations of immunotherapy

Researchers have uncovered a surprising process within a key immune cell that may help explain the limitations of immunotherapy as a cancer treatment.

31 Oct 2017

Infusions of cord blood cells can help improve motor function in children with cerebral palsy

An infusion of cells from a child's own umbilical cord blood appears to improve brain connectivity and motor function in children with spastic cerebral palsy, according to a randomized clinical trial published this week by Stem Cells Translational Medicine.

30 Oct 2017

Using Machine Learning to Accurately Diagnose Childhood Autism Sooner

Autism is a clinical diagnosis. There is no one test to diagnose autism. Depending on the type of medical professional diagnosing, typically the DSM-V (standard classification of mental disorders used by mental health professionals in the U.S.) is used to diagnose by primary care physicians, neurologists, and psychiatrists.

30 Oct 2017

Novartis PARADIGMS study shows safety and efficacy of new treatment in pediatric MS patients

Novartis today announced full results from the positive Phase III PARADIGMS study, investigating the safety and efficacy of Gilenya (fingolimod) vs. interferon beta-1a, in children and adolescents (ages 10 to 17) with multiple sclerosis (MS).

30 Oct 2017

Montmorency tart cherry juice found to help extend sleep time among adults 50 years and older

Montmorency tart cherry juice was found to help extend sleep time by 84 minutes among eight study participants, ages 50 and older who suffer from insomnia, according to a new pilot study published in American Journal of Therapeutics.

28 Oct 2017

CureVac begins phase I study to assess intratumoral application of RNAdjuvant technology in patients with solid tumors

CureVac AG, a fully-integrated biotechnology company pioneering mRNA-based drugs, today announced it has initiated a Phase I study assessing the intratumoral application of its novel RNAdjuvant technology in patients with superficial solid tumors that are easily accessible for repeated intratumoral injections. RNAdjuvant is designed to amplify the scope and quality of an immune response when used alone or in combination with other immune therapies.

28 Oct 2017

Chinese scientists establish synthesis of promising compound to fight against pancreatic cancer

Intriguing antitumor activity is found in a very promising class of natural compounds: cyclic depsipeptides, which have a challenging structure that makes their investigation difficult. Now, Chinese scientists have established the synthesis of a member compound, which is especially promising in killing pancreatic cancer stem cells.

28 Oct 2017

Clinical trial shows promising results for treatment of patients with recurrent high-grade glioma

New data from a Phase I clinical trial led by Clark Chen, M.D., Ph.D., Lyle French Chair in Neurosurgery and Head of the University of Minnesota Medical School Department of Neurosurgery shows more than a quarter of patients with recurrent high-grade glioma, a form of brain cancer, were alive more than three years after treatment.

28 Oct 2017

Genome-wide molecular tests can guide treatment in recurrent glioblastoma, study shows

Several patients with recurring glioblastoma, a deadly brain cancer, survived for more than a year in a clinical trial believed to be the first to use comprehensive DNA and RNA sequencing of a patient's tumor to inform treatment for these patients in real-time.

27 Oct 2017

AACI, CDC, and ACS honor pediatricians who adopt effective HPV vaccination practices

Today the Association of American Cancer Institutes, the American Cancer Society, Inc., and the Centers for Disease Control and Prevention's National Center for Immunization and Respiratory Diseases announced 10 award winners as part of its HPV Vaccine Is Cancer Prevention campaign.

27 Oct 2017

Clinical Trial News and Research

Gut bacteria can influence how cancer responds to immunotherapy

CRFA better than steroid injection for managing pain from knee osteoarthritis

Preclinical studies show effectiveness of targeted therapy for glioblastoma

First-of-its-kind nonsynthetic, decellularized graft one step closer to clinical trials

Poor white matter health may contribute to persistent musculoskeletal pain in Gulf War veterans

PARP inhibitors may have efficacy in selected TNBC patients outside of germline BRCA mutation

Cleveland Clinic researchers win grants to study ethical issues involving brain surgery

GHIT Fund announces US$16.7 million to support development of new drugs, vaccines and diagnostics

New treatment reduces disease burden in patients with rare dermatologic condition

SU2C and its collaborators announce four teams to intercept cancer at earliest stages

Researchers uncover surprising immune cell activity that may explain limitations of immunotherapy

Infusions of cord blood cells can help improve motor function in children with cerebral palsy

Using Machine Learning to Accurately Diagnose Childhood Autism Sooner

Novartis PARADIGMS study shows safety and efficacy of new treatment in pediatric MS patients

Montmorency tart cherry juice found to help extend sleep time among adults 50 years and older

CureVac begins phase I study to assess intratumoral application of RNAdjuvant technology in patients with solid tumors

Chinese scientists establish synthesis of promising compound to fight against pancreatic cancer

Clinical trial shows promising results for treatment of patients with recurrent high-grade glioma

Genome-wide molecular tests can guide treatment in recurrent glioblastoma, study shows

AACI, CDC, and ACS honor pediatricians who adopt effective HPV vaccination practices

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