Cell Division News and Research

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Blocking stress-responsive protein reduces loss of tumor suppressor gene in breast cancer

Over half of all breast cancers carry genetic defects in the p53 gene, a powerful tumor suppressor. Loss of this gene increases the risk of getting breast cancer and the resultant cancers become highly resistant to treatment.

4 Oct 2018

Researchers deplete key protein for DNA replication using protein degradation system

Researchers from Tokyo Metropolitan University and the FIRC Institute of Molecular Oncology in Italy have succeeded in depleting AND-1, a key protein for DNA replication, by using a recently developed conditional protein degradation system.

29 Sep 2018

Researchers uncover molecular underpinnings of liver regeneration

In Greek mythology, Zeus punishes the trickster Prometheus by chaining him to a rock and sending an eagle to eat a portion of his liver every day, in perpetuity. It was the right organ to target - the liver has the ability to regenerate itself, though not overnight nor for eternity.

27 Sep 2018

New approach for bone marrow transplant could make it safer and more effective for patients

Two recent studies in the journal Leukemia present a new approach for bone marrow donation and transplant that preclinical laboratory tests suggest could make the life-saving procedure safer and more effective for patients.

26 Sep 2018

Researchers acquire new insights into DNA polymerases

Complex biological systems can be described as a network of chemical processes that take place in molecules. The scientists of the "ChemLife" research initiative at the University of Konstanz are working together in an equally active network with dynamic interconnections - both subject-specific and interdisciplinary.

19 Sep 2018

Researchers use CRISPR screen to reveal new targets in squamous cell carcinomas

A little p63 goes a long way in embryonic development - and flaws in p63 can result in birth defects like cleft palette, fused fingers or even missing limbs.

18 Sep 2018

Scientists explore whether seafood could be the source of next anti-cancer drug

Biomedical scientists at the University of Salford found that sugars from the common cockle were approximately as effective as some standard chemotherapy drugs at relative lower dosage.

17 Sep 2018

Researchers describe mechanism that sets stage for fate decision of T cells

After a pathogen infects the body, the immune system responds with a remarkable -- and remarkably complicated -- cascade of events.

14 Sep 2018

Molecule produced during fasting appears to have anti-aging effects on vascular system

A molecule produced during fasting or calorie restriction has anti-aging effects on the vascular system, which could reduce the occurrence and severity of human diseases related to blood vessels, such as cardiovascular disease, according to a study led by Georgia State University.

11 Sep 2018

Researchers uncover secret of immortality mechanism in aggressive glioblastoma

UC San Francisco researchers have discovered how a mutation in a gene regulator called the TERT promoter -- the third most common mutation among all human cancers and the most common mutation in the deadly brain cancer glioblastoma -- confers "immortality" on tumor cells, enabling the unchecked cell division that powers their aggressive growth.

10 Sep 2018

Researchers develop the first interactive model of cell division

Researchers have developed an interactive atlas of human cell division, that shows the effect of protein misfolding on mitosis.

10 Sep 2018

Ground-breaking therapeutic process can destroy bowel cancer cells

Researchers at Queen's University Belfast have discovered a ground-breaking therapeutic process that can target and kill bowel cancer cells, which may improve survival rates for bowel cancer patients globally.

6 Sep 2018

Short telomeres could be independent risk factor for age-related functional decline

Elderly people with short chromosome caps, or telomeres, are more likely to have difficulty performing daily activities such as carrying groceries, climbing stairs and walking, finds a new study of more than 1,200 people from five European countries.

6 Sep 2018

Tipping the scales to initiate tumorigenesis in the colon

The regulatory protein c-MYC plays an important role in promoting the development of many types of tumors. c-MYC is a transcription factor that controls the activity of large numbers of genes involved in cell division, and its overexpression leads to excessive cell proliferation.

5 Sep 2018

Scientists explore DNA replication errors that can lead to cancer

Scientists at Hollings Cancer Center at the Medical University of South Carolina have found that some cells can divide without a molecule that was previously thought necessary.

30 Aug 2018

Research into biology behind sperm development could offer hope for solving male infertility

Nearly one in eight couples in the U.S. face infertility, and about half of those cases can be attributed to semen abnormalities in the male partner.

24 Aug 2018

Comprehensive analysis reveals weaknesses to target in common pediatric solid tumor

St. Jude Children's Research Hospital investigators have completed the most comprehensive analysis yet of a common pediatric solid tumor, identifying weaknesses to target and a promising precision medicine that is now in clinical trials.

23 Aug 2018

Scientists pinpoint key gene that controls body segmentation in spiders and insects

Scientists have pinpointed a key gene that controls segmentation during spider development, which reveals a further similarity to the control of segmentation in insects, a study in eLife reports.

21 Aug 2018

Gene therapy with telomerase does not increase cancer risk, study shows

Negative results and findings in science are perhaps less newsworthy, but they are no less important. Particularly when, as in this case, they demonstrate that a possible new therapeutic pathway against idiopathic pulmonary fibrosis and other diseases associated to short telomeres is in fact safe.