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Amino acids signaling controls whole-body glucose homeostasis, study shows

Amino acids are a major nutrient type for humans and are used as building blocks and a source of energy for cells.

16 Mar 2021

Study could lead to the development of novel treatments for drug-resistant cancers

ETC-159, a made-in-Singapore anti-cancer drug that is currently in early phase clinical trials for use in a subset of colorectal and gynecological cancers, could also prevent some tumors from resisting therapies by blocking a key DNA repair mechanism, researchers from Duke-NUS Medical School and the Agency for Science, Technology and Research in Singapore reported in the journal EMBO Molecular Medicine.

16 Mar 2021

Cannabis compound inhibits SARS-CoV-2 replication in human lung cells

Researchers in the United States have conducted a study showing that a cannabis plant compound inhibited infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human lung cells.

14 Mar 2021

New study sheds light on cancer metastasis

Breast cancer is harmful enough on its own, but when cancer cells start to metastasize -- or spread into the body from their original location -- the disease becomes even more fatal and difficult to treat.

12 Mar 2021

Newly discovered cellular stress enzyme may be a target for neurodegenerative disease treatments

An enzyme called MARK2 has been identified as a key stress-response switch in cells in a study by researchers at Johns Hopkins Bloomberg School of Public Health.

11 Mar 2021

Lithium chloride can alleviate radiation-induced oral mucositis and taste dysfunction

Oral mucositis and taste dysfunction (dysgeusia) occurs in nearly all patients receiving head and neck radiotherapy and tremendously affects the quality of life and treatment outcome.

11 Mar 2021

Study opens the door to new possibilities targeting telomeres to help treat cancer

The Telomeres and Telomerase Group led by Maria A. Blasco at the Spanish National Cancer Research Centre continues to make progress in unraveling the role that telomeres -the ends of chromosomes that are responsible for cellular aging as they shorten- play in cancer.

10 Mar 2021

Princeton researchers discover previously unknown organelle that plays role in bone metastasis

Some of Princeton's leading cancer researchers were startled to discover that what they thought was a straightforward investigation into how cancer spreads through the body -- metastasis -- turned up evidence of liquid-liquid phase separations: the new field of biology research that investigates how liquid blobs of living materials merge into each other, similar to the movements seen in a lava lamp or in liquid mercury.

9 Mar 2021

Impairments in immune response contribute to severe COVID-19

New research by a team of scientists at University Hospital RWTH Aachen in Germany and Erasmus Medical Centre in The Netherlands characterized changes in CD8+ T cells in response to SARS-CoV-2.

8 Mar 2021

SARS-CoV-2 escapes host immune responses by modulating dendritic cell maturation

A team of scientists from Italy and the USA has recently explored the maturation pattern of conventional dendritic cells (cDCs) during SARS-CoV-2 infection.

5 Mar 2021

Cell surface marker CD47 may allow early diagnosis of severe COVID-19

A new study reports the potential of the cell surface marker, CD47, as a biomarker for hyperinflammation, a characteristic feature of severe COVID-19.

4 Mar 2021

Study demonstrates the novel agonistic effect of curcumin on lipid transcription

Curcumin is a polyphenol compound produced by plants of the Curcuma longa species and has been reported to have many physiological activities, which include anti-oxidation, anti-inflammatory, anti-cancer, and anti-amyloid properties.

27 Feb 2021

Proteins play crucial role in muscle growth

When a muscle grows, because its owner is still growing too or has started exercising regularly, some of the stem cells in this muscle develop into new muscle cells.

26 Feb 2021

High expression of ACE2 receptors in developing ovaries increases SARS-CoV-2 risk

A team of scientists from China collaborated to find if SARS-CoV-2 could also infect the ovary at different developmental stages.

25 Feb 2021

Hormone known to prevent weight gain can help maintain healthy muscles in mice

A new study suggests that a hormone known to prevent weight gain and normalize metabolism can also help maintain healthy muscles in mice.

23 Feb 2021

Influenza A virus defective interfering particles against SARS-CoV-2

In the search for a broadly acting pan-specific antiviral, an interdisciplinary team from Germany tested the previously proposed (for antiviral treatment against Influenza A infections) - Influenza A virus (IAV) defective interfering particles (DIPs). The research is published online on the bioRxiv preprint server.

23 Feb 2021

Why can SARS-CoV-2 infection cause neurological and cardiovascular symptoms?

Researchers from Columbia University Vagelos College of Physicians & Surgeons, USA, present results linking oxidative stress and the activation of a biochemical pathway associated with Alzheimer’s disease to SARS-CoV-2 infection.

22 Feb 2021

Study could lead to new strategies to prevent various cancers

Chronic inflammation drives the development of various cancers, including those of the skin, colon and pancreas. Investigators at Massachusetts General Hospital (MGH) who previously demonstrated high expression levels of an immune molecule called interleukin-33 (IL-33) during cancer-promoting inflammation have now uncovered the details behind the molecule's effects.

22 Feb 2021

Study identifies immune profile of people with severe COVID-19

A team of researchers at Georgetown University Medical Center, USA, investigated how SARS-CoV-2 affects the immune system’s response during and after infection and contributes to the severity of COVID-19.

22 Feb 2021

Cissampelos pareira L. extracts demonstrate anti-SARS-CoV-2 activity in vitro

A team of scientists from India has recently investigated the antiviral potency of a traditional medicinal plant Cissampelos pareira L. in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The findings reveal that both whole-plant extracts and bioactive compounds can inhibit SARS-CoV-2 replication by modulating estrogen receptor 1 (ESR1) activity.

21 Feb 2021

Signaling Pathway News and Research

Amino acids signaling controls whole-body glucose homeostasis, study shows

Study could lead to the development of novel treatments for drug-resistant cancers

Cannabis compound inhibits SARS-CoV-2 replication in human lung cells

New study sheds light on cancer metastasis

Newly discovered cellular stress enzyme may be a target for neurodegenerative disease treatments

Lithium chloride can alleviate radiation-induced oral mucositis and taste dysfunction

Study opens the door to new possibilities targeting telomeres to help treat cancer

Princeton researchers discover previously unknown organelle that plays role in bone metastasis

Impairments in immune response contribute to severe COVID-19

SARS-CoV-2 escapes host immune responses by modulating dendritic cell maturation

Cell surface marker CD47 may allow early diagnosis of severe COVID-19

Study demonstrates the novel agonistic effect of curcumin on lipid transcription

Proteins play crucial role in muscle growth

High expression of ACE2 receptors in developing ovaries increases SARS-CoV-2 risk

Hormone known to prevent weight gain can help maintain healthy muscles in mice

Influenza A virus defective interfering particles against SARS-CoV-2

Why can SARS-CoV-2 infection cause neurological and cardiovascular symptoms?

Study could lead to new strategies to prevent various cancers

Study identifies immune profile of people with severe COVID-19

Cissampelos pareira L. extracts demonstrate anti-SARS-CoV-2 activity in vitro

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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