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Ketogenic diet can boost efficacy of pancreatic cancer therapy

A study of fasting and the ketogenic diet reveals a new vulnerability of pancreatic tumors to an existing cancer drug.

14 Aug 2024

Review explores potential for improved use of anti-angiogenic agents in cancer therapy

Most tumors release various signaling molecules to support their incessant growth, invasion, and metastasis.

9 Aug 2024

AACR CEO Dr. Margaret Foti honored as 2024 Beacon Award recipient for leadership in oncology

The AIM-HI Accelerator Fund today announces Margaret Foti, PhD, MD (hc), Chief Executive Officer of the American Association for Cancer Research (AACR), is selected unanimously by the 2024 Blue Ribbon Selection Committee as the recipient of the 2024 Beacon Award for Women Leaders in Oncology, from a pool of outstanding global nominees.

9 Aug 2024

Insilico Medicine's pan-TEAD inhibitor ISM6331 receives FDA IND clearance for mesothelioma treatment

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, today announced ISM6331, potential best-in-class pan-TEAD inhibitor, has received the U.S. Food and Drug Administration (FDA) Investigational New Drug (IND) clearance for the treatment of mesothelioma, following the grant of Orphan Drug Designation (ODD) in June 2024. It brings the total number of IND-approved molecules of Insilico to nine.

8 Aug 2024

Study highlights the need for language services in cancer trials

Underrepresentation of racial and ethnic minority populations in cancer clinical trials persists partly because translation and interpretation services and resources are unavailable or inadequate in the United States, according to a Children's Oncology Group (COG) study led by Columbia University School of Nursing. The updated study was published online in the Journal of the National Cancer Institute Cancer Spectrum on July 25, 2024, and will appear in the August 2024 journal issue.

7 Aug 2024

Using advanced CRISPR to boost efficiency of CAR-T cell therapies

CAR-T cells are highly effective in treating selected blood cancers. However, challenges remain with this new therapy, which was first approved in 2017 in the USA and a year later in Europe for treating acute lymphoblastic leukemia (ALL).

2 Aug 2024

New frontiers in organ regeneration with 3D bioprinting

In a latest review published in Engineering, an international team of scientists from China and the United States has presented a comprehensive analysis of the latest advancements in 3D organ bioprinting. This innovative technology holds the potential to revolutionize regenerative medicine and tackle some of the most pressing issues in organ transplantation.

2 Aug 2024

Propofol shows potential for treating epilepsy and neurological disorders

The general anesthetic propofol may hold the keys to developing new treatment strategies for epilepsy and other neurological disorders, according to a study led by researchers at Weill Cornell Medicine and Linköping University in Sweden.

31 Jul 2024

New discovery unveils key process in DNA repair pathway

An elegant collaboration between researchers in the UK's two core-funded Medical Research Council Research Institutes, the Laboratory of Medical Sciences (LMS) in London and the Laboratory of Molecular Biology (LMB) in Cambridge, has solved a decades-old mystery which could pave the way to better cancer treatments in the future.

31 Jul 2024

ACE technology enhances single-cell protein detection with advanced signal amplification

Since the 1950s, researchers have used a famous method invented by Wallace Coulter known as "flow cytometry" to characterize different types of immune cells in research studies and in blood samples from human individuals.

30 Jul 2024

Advancing hepatic cell carcinoma treatment through mitochondrial DNA targeting

Hepatic cell carcinoma (HCC), the fifth most prevalent malignancy worldwide and the fourth leading cause of cancer-related mortality, poses significant therapeutic challenges.

29 Jul 2024

Early classroom-based health education prevents abdominal fat accumulation in children

A study led by the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and Fundación SHE, supported by "la Caixa" Foundation, demonstrates that teaching healthy habits through classroom activities helps to prevent the accumulation of abdominal fat during the first school years.

29 Jul 2024

Motor neurone disease research receives major boost through new data catalyst initiative

Research into the life-shortening neurological condition motor neurone disease (MND) will receive a major boost through the formation of a new data catalyst led by Health Data Research UK (HDR UK) and Dementia Platforms UK (DPUK).

29 Jul 2024

UK initiative aims to transform MND research through health data collaboration

MND is a devastating disease affecting the motor neurones in the brain and spinal cord, leading to progressive muscle weakness and paralysis.

25 Jul 2024

Proteomic signatures enhance risk prediction for both common and rare diseases

Researchers have developed sparse prediction models combining plasma proteins and clinical data to predict the 10-year risk of 218 diseases. The study, involving over 41,000 participants, highlights the enhanced predictive power of proteomic signatures.

24 Jul 2024

Experts unveil first comprehensive guidelines for precision medicine research

A University of Virginia School of Medicine scientist and other top experts from around the world have developed the first comprehensive guidelines for reporting cutting-edge "precision medicine" research in a bid to improve patient care and health equity for people everywhere.

22 Jul 2024

Study links circadian rhythm disruption to obesity and diabetes

Disruption of circadian rhythms and clock gene expression is linked to adverse metabolic health outcomes, including obesity and diabetes. Further research is needed to understand these relationships and their implications for treatment and prevention.

17 Jul 2024

UIC researchers explore digital tools to personalize depression treatment

New research at the University of Illinois Chicago is testing whether digital tools can help predict which patients with depression will benefit from specific treatments and help deliver those treatments to them on demand.

16 Jul 2024

Immune protein C1q impacts neuronal protein synthesis in the aging brain, study reveals

A groundbreaking study conducted at the lab of Beth Stevens, PhD, at Boston Children's Hospital has revealed that an immune protein impacts neuronal protein synthesis in the aging brain.

15 Jul 2024

ARPA-H funding boosts Wyss Institute's RNA therapeutic project

With the award for up to $27 million from the Advanced Research Projects Agency for Health (ARPA-H), a collaborative research project at the Wyss Institute for Biologically Inspired Engineering at Harvard University will advance a disease-agnostic novel RNA therapeutic with the potential to treat diverse diseases, and to be effectively and rapidly deployable.

15 Jul 2024