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New trial examines the effectiveness of combination immunotherapy for platinum-resistant ovarian cancer

A new clinical trial studying the effectiveness of a combination of immunotherapy treatments could be more effective for patients with ovarian cancer who are resistant to traditional interventions.

6 Jun 2022

Taking everolimus post-surgery can improve outcomes in patients with high-risk renal cell carcinoma

In a study of patients with high-risk renal cell carcinoma, those who took the drug everolimus daily for up to one year after surgery lived longer without their disease returning (recurrence-free survival, or RFS) than those who did not take everolimus, although the results narrowly missed the clinical trial's prespecified level for statistical significance.

4 Jun 2022

Researchers repurpose a cancer drug for the treatment of neuroinflammatory diseases

The repurposing of FDA-approved drugs for alternative diseases is a faster way of bringing new treatments into the clinic.

3 Jun 2022

Molecular 'connector' may underlie gender differences in cocaine’s effects, mice study shows

Scientists have long known that cocaine works by latching on to molecular connectors on the surface of brain cells, allowing dopamine, a chemical that promotes feelings of pleasure and reward, to accumulate in the space between brain cells.

3 Jun 2022

Exploring the effectiveness of various treatments in people with axial spondyloarthritis

axSpA is a chronic inflammatory rheumatic disease that mainly affects the spine and sacroiliac joints. It can cause significant pain and disability.

3 Jun 2022

Novel approach identifies potent drug-like molecules that bind to cancer protein of interest

Researchers at Baylor College of Medicine and Texas Children's Hospital have identified potent, highly specific compounds that interfere with bromodomain (BD)-containing proteins involved in cancer.

3 Jun 2022

Researchers identify predictive biomarkers to fight against non-small cell lung cancer

In a recent study, researchers at the University of Missouri are identifying new minimally invasive biomarkers to develop a blood test for early detection of non-small cell lung cancer (NSCLC), one of two main types of lung cancer.

3 Jun 2022

$New combination of drugs increases survival time for some patients with refractory lung cancer$

New combination of drugs increases survival time for some patients with refractory lung cancer

A combination of the drugs ramucirumab and pembrolizumab reduced risk of death by 31% compared with the standard of care in patients with advanced non-small cell lung cancer that had progressed on prior immunotherapy.

3 Jun 2022

Study uncovers differences in genetic mutations between younger and older breast cancer patients

Women younger than 40 years of age with advanced breast cancer often suffer from more aggressive disease and worse prognoses than their older counterparts.

3 Jun 2022

Study: Nearly 43% of patients with KRAS-mutated lung cancer respond to experimental drug adagrasib

Nearly 43% of patients with non-small cell lung cancer (NSCLC) whose lung cancers harbored a specific KRAS mutation responded to the experimental drug adagrasib, and the targeted agent also showed activity against lesions in the brain that metastasized from the lung tumors, according to results of a study led by Dana-Farber Cancer Institute investigators.

3 Jun 2022

Computer vision tool effectively distinguishes rheumatoid arthritis from osteoarthritis in joint tissue

A new study led by Hospital for Special Surgery investigators in New York City has found that their computer vision tool effectively distinguishes rheumatoid arthritis (RA) from osteoarthritis (OA) in joint tissue taken from patients who underwent total knee replacement (TKR).

3 Jun 2022

New method to combat malaria turns the disease against itself

A new method to combat malaria which sees the disease turn against itself could offer an effective treatment for the hundreds of millions of people infected globally each year, as the efficacy of current antimalarial drugs weakens.

3 Jun 2022

Diabetes drug's target protein can be a candidate for the treatment of Alzheimer's disease

Mechanisms associated with a particular diabetes drug can also help to protect against Alzheimer's disease, a study by researchers at Karolinska Institutet in Sweden and published in Neurology reports.

3 Jun 2022

Women are seldom informed about contraceptive failure following common anesthetic use

Women undergoing operations are not being routinely informed that a common anesthetics may make their contraception less effective, putting them at risk of an unplanned pregnancy, new research being presented at Euroanaesthesia, the annual meeting of the European Society of Anaesthesiology and Intensive Care (ESAIC) in Milan, Italy (4-6 June), suggests.

3 Jun 2022

New, efficient protocol to generate microglia from human pluripotent cells for retinal development

This study is led by prof. Jin (Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University).

3 Jun 2022

Genetically engineered immune cells target cancer cells that may be responsible for leukemia relapse

Genetically engineered immune cells successfully target the specific cancer cells that may be responsible for relapse of acute myeloid leukemia (AML), a type of blood cancer, and proved effective in animal models of the disease, according to a preclinical study by investigators at Weill Cornell Medicine.

2 Jun 2022

New compound shows promise to kill a range of hard-to-treat cancer types

A compound, developed by a team including scientists from The University of Texas Health Science Center at San Antonio, kills a range of hard-to-treat cancer types in petri dishes and animal models by targeting a previously unexploited vulnerability, a new study reports.

2 Jun 2022

Multidisciplinary medical team needed to provide care for pregnant women with lupus, study says

A study that includes researchers at Hospital for Special Surgery underscores the importance of a multidisciplinary medical team to counsel and provide care for women with systemic lupus erythematosus, the most common form of lupus, who become pregnant.

2 Jun 2022

Truncated tau protein may be a means for better diagnosis and treatment of Alzheimer's disease

In a new study of Alzheimer's disease, researchers at UC San Francisco have discovered that a relatively unstudied form of the tau protein associated with neurodegeneration may be a means for better diagnosis and treatment of the disease.

2 Jun 2022

Immune modulator drugs improved clinical status, reduced deaths among patients hospitalized with COVID-19

A large randomized, placebo-controlled clinical trial led by the National Institutes of Health shows that treating adults hospitalized with COVID-19 with infliximab or abatacept - drugs widely used to treat certain autoimmune diseases - did not significantly shorten time to recovery but did substantially improve clinical status and reduce deaths.

2 Jun 2022

Drugs News and Research

New trial examines the effectiveness of combination immunotherapy for platinum-resistant ovarian cancer

Taking everolimus post-surgery can improve outcomes in patients with high-risk renal cell carcinoma

Researchers repurpose a cancer drug for the treatment of neuroinflammatory diseases

Molecular 'connector' may underlie gender differences in cocaine’s effects, mice study shows

Exploring the effectiveness of various treatments in people with axial spondyloarthritis

Novel approach identifies potent drug-like molecules that bind to cancer protein of interest

Researchers identify predictive biomarkers to fight against non-small cell lung cancer

New combination of drugs increases survival time for some patients with refractory lung cancer

Study uncovers differences in genetic mutations between younger and older breast cancer patients

Study: Nearly 43% of patients with KRAS-mutated lung cancer respond to experimental drug adagrasib

Computer vision tool effectively distinguishes rheumatoid arthritis from osteoarthritis in joint tissue

New method to combat malaria turns the disease against itself

Diabetes drug's target protein can be a candidate for the treatment of Alzheimer's disease

Women are seldom informed about contraceptive failure following common anesthetic use

New, efficient protocol to generate microglia from human pluripotent cells for retinal development

Genetically engineered immune cells target cancer cells that may be responsible for leukemia relapse

New compound shows promise to kill a range of hard-to-treat cancer types

Multidisciplinary medical team needed to provide care for pregnant women with lupus, study says

Truncated tau protein may be a means for better diagnosis and treatment of Alzheimer's disease

Immune modulator drugs improved clinical status, reduced deaths among patients hospitalized with COVID-19

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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