Electron Microscopy News and Research

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High-resolution images offer clues to improve design of anti-nausea drugs

A new study using a special type of electron microscope using samples cooled to extremely cold temperatures provides critical information for drug developers seeking to reduce nausea and vomiting side effects of cancer treatments.

23 Jul 2019

Researchers identify toxin responsible for Legionella growth

A team of scientists led by EMBL group leader Sagar Bhogaraju and Ivan Dikic of Goethe University, Frankfurt, discovered that the toxin SidJ in Legionella bacteria enforces a unique modification on human proteins and helps legionella grow inside human cells.

22 Jul 2019

Chemists discover a whole new class of microbial recipes

Microbes are master chefs of the biomolecular world; collectively, they harbor the ability to produce a vast array of unknown substances, some of which may have therapeutic or other useful properties.

22 Jul 2019

Hinge-like protein may unlock new pathways for cystic fibrosis treatment

In recent decades, treatment options for people with cystic fibrosis have improved dramatically. The newest drugs, known as potentiators, target a protein called cystic fibrosis transmembrane conductance regulator, which is mutated in people with the disease.

10 Jul 2019

Researchers capture high-resolution, 3D images of gene-editing enzymes

For the first time, scientists have captured high-resolution, three-dimensional images of an enzyme in the process of precisely cutting DNA strands.

9 Jul 2019

Using NMR to Study Protein Structure, Dynamics and Mechanisms

Fábio Almeida describes how NMR can be used to elucidate protein structure and how this data can be applied to human disease.

From Bruker BioSpin - NMR, EPR and Imaging 4 Jul 2019

BioSA team aims to develop improved bone regeneration scaffold design

Millions of patients all over the world undergo surgical procedures related to bone defect repair every year.

2 Jul 2019

Scientists unravel how cells unfold proteins

A happy cell is a balanced cell, but for every stupendously twisted protein it creates, it must tear the old ones asunder. That means untangling a convoluted pretzel-like mass for recycling. Cdc48 plays a critical role in unraveling the spent proteins.

29 Jun 2019

Cutting-edge electron microscopy reveals first structures of a lipid-flippase

Using cutting-edge electron microscopy, researchers from Aarhus University have determined the first structures of a lipid-flippase.

29 Jun 2019

Researchers challenge conventional understanding of cause of Parkinson's

An international team of researchers involving members of the University of Basel's Biozentrum challenges the conventional understanding of the cause of Parkinson's disease.

26 Jun 2019

Scientists discover weakness in common cold virus

Scientists have discovered a weakness on the surface of the viruses that cause a multitude of illnesses.

12 Jun 2019

Proteasome inhibitors show potential for combating multidrug-resistant malaria

Proteasome inhibitors have significant promise as components of novel combination therapies to treat multidrug-resistant malaria, according to a study published June 6 in the open-access journal PLOS Pathogens by David Fidock, Caroline Ng, and Barbara Stokes of Columbia University Irving Medical Center, Matthew Bogyo of Stanford University School of Medicine, and colleagues.

From PLOS ONE 10 Jun 2019

Snapshot of chikungunya could help find new ways to prevent or treat viral arthritis

Chikungunya virus, once confined to the Eastern Hemisphere, has infected more than 1 million people in the Americas since 2013, when mosquitoes carrying the virus were discovered in the Caribbean.

4 Jun 2019

Scientific discovery may lead to a treatment for lupus

A team of scientists has uncovered the structure of a regulatory complex that is involved in the release of cytokines and can be inhibited to treat lupus.

31 May 2019

Researchers identify new mechanism for accessing damaged DNA

UV light damages the DNA of skin cells, which can lead to skin cancer.

31 May 2019

Researchers find new molecular targets for fighting autoimmunity

BRCA--the family of DNA-repair proteins associated with breast, ovarian prostate, and pancreatic cancers--interacts with a multipart, molecular complex that is also responsible for regulating the immune system.

30 May 2019

A final comfort: ‘Palliative transport’ brings dying children home

Anne Brescia sat beside her only child, Anthony, as he lay unconscious in a hospital bed at age 16. Just a few months before, he was competing in a swim meet; now cancer was destroying his brain. Brescia couldn’t save her son. But she was determined to bring him home.

28 May 2019