Electron Microscopy News and Research

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SARS-CoV-2 infection induces accumulation of lipids and N-proteins

Scientists from the Netherlands and the US recently studied the localization of the SARS-CoV-2 proteins in postmortem lung tissues of COVID-19 patients and in SARS-CoV-2 infected Vero cells that were processed identically. The research is posted to the bioRxiv* preprint server, prior to peer review.

29 Jun 2021

New study reveals how heparan sulfate promotes amyloid deposition in various organs

Amyloid diseases, including Alzheimer's, Parkinson's, type-2 diabetes and other life-threatening diseases, involve pathologic deposits of normally soluble proteins or peptides as insoluble amyloid fibrils. When this happens in vital organs, such as the brain, kidney, liver and heart, it causes organ damage and, if left untreated, death. Unfortunately, the available treatment options are very limited.

29 Jun 2021

Discovery opens door to new diagnostics and therapeutic strategies for male infertility

Scientists at The University of Toledo discovered new movement in sperm that provides innovative avenues for diagnostics and therapeutic strategies for male infertility.

28 Jun 2021

Structural studies of SARS-CoV-2 spike protein reveal new properties of Alpha and Beta variants

New SARS-CoV-2 variants are spreading rapidly, and there are fears that current COVID-19 vaccines won't protect against them.

25 Jun 2021

Researchers determine molecular structure of bacterial protein complex critical for tuberculosis

Tuberculosis is one of the top ten causes of death worldwide, infecting about one-quarter of the world's population. Although it is treatable, the rise of multidrug-resistant tuberculosis poses a major threat to global health security, and has been declared by the World Health Organization as a global health emergency.

25 Jun 2021

Fundamental insights on key protein can help strengthen plants against environmental stress

An international study led by Helmholtz Zentrum München has revealed the structure of a membrane-remodeling protein that builds and maintains photosynthetic membranes. These fundamental insights lay the groundwork for bioengineering efforts to strengthen plants against environmental stress, helping to sustaining human food supply and fight against climate change.

25 Jun 2021

Surprising similarities found in membrane proteins of bacteria and humans

The cells of simple organisms, such as bacteria, as well as human cells are surrounded by a membrane, which fulfills various tasks including protecting the cell from stress.

24 Jun 2021

Chan Zuckerberg Initiative announces nearly $28 million for visual proteomics

Today, the Chan Zuckerberg Initiative (CZI) announced nearly $28 million in grants to support technology developments that will allow researchers to see the inner workings of cells at near-atomic resolution through next-generation electron microscopy.

18 Jun 2021

New details on transport protein could help develop drugs for neurological diseases

New details on the structure and function of a transport protein could help researchers develop drugs for neurological diseases that are better able to cross the blood-brain barrier.

18 Jun 2021

New computational technique greatly increases the resolution of atomic force microscopy

Scientists at Weill Cornell Medicine have developed a computational technique that greatly increases the resolution of atomic force microscopy, a specialized type of microscope that "feels" the atoms at a surface.

17 Jun 2021

Scientists decipher the activation mechanism of a chemokine receptor

Chemokine receptors, located at the surface of many immune cells, play an important role in their function. Chemokines are small proteins that bind to these receptors and control the movement and behavior of white blood cells.

16 Jun 2021

Study reveals structural details of omega-3 fatty acid transport across the blood–brain barrier

Spectacular images of a molecule that shuttles omega-3 fatty acids into the brain may open a doorway for delivering neurological therapeutics to the brain.

16 Jun 2021

A closer look at how COVID-19 damages human lungs

A recent study conducted at the United States Department of Energy’s (DOE) Brookhaven National Laboratory provides the first atomic-level detailed model of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope protein when bound to human proteins within the lungs. The study was recently published in Nature Communications.

9 Jun 2021

New atomic-level model helps explain how SARS-CoV-2 causes extensive lung damage

Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have published the first detailed atomic-level model of the SARS-CoV-2 "envelope" protein bound to a human protein essential for maintaining the lining of the lungs.

8 Jun 2021

Researchers find natural metabolites help SARS-CoV-2 escape antibodies

An international team of scientists has identified a human molecule — biliverdin — as a potential severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) target. The binding of the heme metabolite to the N-terminal domain of SARS-CoV-2 is associated with the virus’s ability to dodge the immune system by suppressing antibody binding to the spike protein.

2 Jun 2021

Direct action of SARS-CoV-2 on organs may lead to exacerbated inflammatory response in pediatric patients

Besides common symptoms such as fever, cough and respiratory distress, some children have an atypical form of COVID-19 known as multisystem inflammatory syndrome in children (MIS-C), characterized by persistent fever and inflammation of several organs, such as the heart and intestines, as well as the lungs to a lesser extent.

1 Jun 2021

Electron Microscopy News and Research

SARS-CoV-2 infection induces accumulation of lipids and N-proteins

New study reveals how heparan sulfate promotes amyloid deposition in various organs

Discovery opens door to new diagnostics and therapeutic strategies for male infertility

Structural studies of SARS-CoV-2 spike protein reveal new properties of Alpha and Beta variants

Researchers determine molecular structure of bacterial protein complex critical for tuberculosis

Fundamental insights on key protein can help strengthen plants against environmental stress

Surprising similarities found in membrane proteins of bacteria and humans

Chan Zuckerberg Initiative announces nearly $28 million for visual proteomics

New details on transport protein could help develop drugs for neurological diseases

New computational technique greatly increases the resolution of atomic force microscopy

Scientists decipher the activation mechanism of a chemokine receptor

Study reveals structural details of omega-3 fatty acid transport across the blood–brain barrier

A closer look at how COVID-19 damages human lungs

New atomic-level model helps explain how SARS-CoV-2 causes extensive lung damage

Researchers find natural metabolites help SARS-CoV-2 escape antibodies

Direct action of SARS-CoV-2 on organs may lead to exacerbated inflammatory response in pediatric patients

Scientists use an original approach to resolve the 3D structure of flaviviruses

Researchers discover cross-reactive coronavirus antibody triggered during COVID-19 infection

Potent antibody with unique genetic signature and spike recognition mechanism neutralizes SARS-CoV-2

Study reveals the first complete 3D molecular structure of immature flavivirus

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