Glycoprotein News and Research

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Sleeping sickness parasite exhibits metabolic flexibility and adaptability

Parasitic protozoa called trypanosomes synthesize sugars using an unexpected metabolic pathway called gluconeogenesis, according to a study published December 27 in the open-access journal PLOS Pathogens by David Horn of the University of Dundee in the UK, and colleagues.

28 Dec 2018

New review focuses on the structure-activity relationships of flavonoids

ABCB1 in the ABC transporter family also termed as P-glycoprotein, grants the simultaneous resistance of metastatic cancer cells towards various anti-cancer drugs with different targets and diverse chemical structures.

27 Dec 2018

Person's sex hormones may play key role in trauma survival, finds study

A person's sex hormones may play a role in trauma survival, according to a Kansas State University researcher who has received a $650,000 grant from the U.S. Department of Defense.

16 Nov 2018

Chronic inflammation linked with increased risk of multiple diseases and shorter lifespan

Researchers have elucidated the disease risk underlying a biomarker predictive of shorter lifespan.

2 Nov 2018

New vaccine shows effective protection in animal models of Lassa fever

Lassa fever belongs to the same class of hemorrhagic fevers as Ebola. Like Ebola, it has been a major health threat in Western Africa, infecting 100,000-300,000 people and killing 5,000 per year.

11 Oct 2018

Rare antibodies could be key ingredients in therapeutics capable of neutralizing many Ebola types

Two new studies by scientists at Scripps Research are bringing Ebola virus's weaknesses into the spotlight, showing for the first time exactly how human and mouse antibodies can bind to the virus and stop infection--not only for Ebola virus, but for other closely related pathogens as well.

13 Sep 2018

Current, intense physical activity associated with healthy metabolic profile in adolescents

More time spent intensely active, to a greater extent than less time spent sedentary, correlates with a healthier metabolic profile in adolescence, according to a study published this week in PLOS Medicine.

12 Sep 2018

Study provides new insights into how the human immune system protects against Ebola infections

Two types of human antibodies that target different parts of the Ebola virus synergize their antiviral effects by inhibiting different steps of infection, according to a study published August 23 in the open-access journal PLOS Pathogens by Philipp Ilinykh and colleagues from the University of Texas Medical Branch, Vanderbilt University, and Ragon Institute.

24 Aug 2018

Scientists develop universal vaccine with the potential to protect against multiple flu strains

Researchers have developed a universal vaccine that can protect against multiple strains of influenza in animals.

22 Aug 2018

Newly discovered mechanism may be useful target to stop flu virus from infecting cells

There's a hitch in the swing of a protein that delivers the flu virus. Rice University and Baylor College of Medicine researchers believe this mechanism may be a useful target to stop the virus from infecting cells.

24 Jul 2018

New study provides important clues to developing more effective Ebola vaccines

Scientists conducting the first comprehensive study of key immune system cells-;collected from West African Ebola survivors that kill Ebola infected cells have made a surprising discovery that provides important clues to developing effective vaccines against the infection.

24 Jul 2018

Researchers develop novel approach to bridge gap in cell-free systems

Engineering cellular biology, minus the actual cell, is a growing area of interest in biotechnology and synthetic biology.

13 Jul 2018

Targeting proteins in semen could prevent sexually transmitted spread of Ebola virus

Protein fragments, called amyloid fibrils, in human semen significantly increase Ebola virus infection and protect the virus against harsh environmental conditions such as heat and dehydration. Researchers from the Perelman School of Medicine at the University of Pennsylvania report these findings in a study published this week in the Proceedings of the National Academy of Sciences.

26 Jun 2018

Computer models provide valuable insight to structure and function of Ebola, Zika viruses

The viruses that cause Ebola and Zika, daunting diseases that inspire concern at every outbreak, share a strong similarity in how they first infiltrate a host's cells. Through the computer modeling capabilities of Los Alamos National Laboratory, the molecular calisthenics involved in invading a cell are visually documented, an essential step toward vaccine and therapeutic medicine development.

15 May 2018

Mutations in EBOV-Makona do not alter disease-causing ability in animal models, shows study

Early during the recent Ebola epidemic in West Africa, scientists speculated that the genetic diversity of the circulating Makona strain of virus (EBOV-Makona) would result in more severe disease and more transmissibility than prior strains.

9 May 2018

New chemical trap catches trace glycoproteins, shows promise for targeted cancer treatments

Cancer drops sparse chemical hints of its presence early on, but unfortunately, many of them are in a class of biochemicals that could not be detected thoroughly, until now.

8 May 2018

Keck School of Medicine of USC wins two grants to support osteoarthritis research

A researcher at the Keck School of Medicine of USC has been awarded two grants totaling more than $4 million to support osteoarthritis research.

4 May 2018

Exploiting rabies virus machinery to usher Parkinson's disease drug directly to the brain

The rabies virus wreaks havoc on the brain, triggering psychosis and death. To get where it needs to go, the virus must first trick the nervous system and cross the blood brain barrier -- a process that makes it of interest in drug design.

25 Apr 2018

The Importance of Fetal Fibronectin Testing for Women with Symptomatic Preterm Labor

Preterm birth is a dangerous condition that often goes undiagnosed. Fetal fibronectin (fFN) is a biomarker for preterm labor, but testing for fFN is widely underused. We explore this issue with Dr. Michael S. Ruma, a maternal-fetal specialist from the Perinatal Associates of New Mexico.

14 Mar 2018

Australian brings measles to New York sparking fears for unvaccinated

According to the city officials in New York, the small population of unvaccinated individuals need to be extra careful over the next couple of weeks because an Australian individual with suspected measles has arrived in the city. This announcement was made last Friday by the New York State Department of Health.

26 Feb 2018