Kidney News and Research

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New therapies for acute kidney injury show promise

Acute kidney injury (AKI) is a severe renal disorder affecting approximately 10%-15% of hospitalized patients and up to 50% in intensive care units (ICUs). Its pathogenesis involves complex inflammatory regulatory mechanisms. As core components of the cytokine network, interleukins (ILs) exert pleiotropic effects in AKI development, extensively participating in inflammation, fibrosis, tissue injury repair, and remote organ damage.

18 Aug 2025

Genetically-engineered immune cells show promise for preventing organ rejection

A Medical University of South Carolina team reports in Frontiers in Immunology that it has engineered a new type of genetically modified immune cell that can precisely target and neutralize antibody-producing cells complicit in organ rejection.

17 Aug 2025

Trial finds no cardiovascular benefit and higher safety risks with spironolactone in dialysis patients

A large international study has found that spironolactone, a medication for high blood pressure and heart failure, does not reduce the risk of heart-related death or hospitalizations in people with kidney failure receiving dialysis, despite earlier smaller studies suggesting benefit.

17 Aug 2025

International experts recommend broader use of cardioprotective diabetes drugs

SGLT-2 inhibitor and GLP-1 receptor agonist drugs should be used in all or almost all adults with type 2 diabetes at higher risk of cardiovascular and kidney complications, and in the majority of adults at moderate risk of complications, say a panel of international experts in The BMJ today.

17 Aug 2025

New 2025 guidelines focus on early intervention and lifestyle to manage high blood pressure

Preventing and managing high blood pressure with healthy lifestyle behaviors, such as following a heart-healthy diet including reducing salt intake, staying physically active, maintaining a healthy weight and managing stress—combined with early treatment with medication to lower blood pressure if necessary—are recommended to reduce the risk of heart attack, stroke, heart failure, kidney disease, cognitive decline and dementia, according to a new clinical guideline published today in the American Heart Association's peer-reviewed journals Circulation and Hypertension, and in JACC, the flagship journal of the American College of Cardiology.

14 Aug 2025

PFAS exposure increases risk of weight regain after adolescent bariatric surgery

Adolescents who undergo bariatric surgery face a higher risk of weight regain, which can undermine treatment success and long-term health, if they have elevated blood levels of per- and polyfluoroalkyl substances (PFAS) prior to the procedure, according to new USC research.

14 Aug 2025

New drug discovery platform aims to deliver first-in-class therapies

65LAB has awarded US$1.5 million (approx. S$1.9 million) to Professor Enrico Petretto to advance a breakthrough drug discovery platform developed at Duke-NUS Medical School. The project aims to deliver first-in-class antifibrotic therapies for lung and kidney diseases-conditions that currently have no effective treatment.

14 Aug 2025

NYU Langone Hospital—Suffolk performs first robotic cancer surgeries

Continuing its transformation since joining NYU Langone Health, the operative team at NYU Langone Hospital—Suffolk recently performed four complex robotic surgeries that had never been offered at the facility before, three of which successfully removed cancerous tumors from patients.

13 Aug 2025

New research explores foot positioning to treat knee osteoarthritis

Gait analysis and pain measures show that subtly adjusting the angle of the foot during walking may reduce knee pain caused by osteoarthritis. This approach may also slow progression of the condition, an uncurable disease in which the cartilage cushion inside a joint breaks down.

13 Aug 2025

Long COVID linked to lasting financial hardship and work disruption

While the economic impact of the COVID-19 pandemic continues to be widely studied and debated, the financial toll of the COVID-19 pandemic for individual patients is less understood.

12 Aug 2025

Study identifies biomarkers that could help predict and manage chronic kidney disease

Biomarkers that could help predict and manage chronic kidney disease (CKD) have been identified in a new study led by the University of Surrey.

12 Aug 2025

3D-printed kidney tumors offer a new tool in the fight against renal cancer

Scientists at Tsinghua University have developed a method to grow kidney tumors in the lab using cells from real patients, offering a potential new tool in the fight against renal cancer.

12 Aug 2025

New research highlights combined impact of genes and lifestyle on dilated cardiomyopathy

An international team, led by scientists from the Victor Chang Cardiac Research Institute has studied around 3000 people affected by the heart disease dilated cardiomyopathy (DCM) – a driver of heart failure and sudden cardiac arrest.

12 Aug 2025

Fifteen-year study shows major gains in diabetes technology use and patient outcomes

A new study led by researchers at the Johns Hopkins Bloomberg School of Public Health found big increases in the use of continuous glucose monitoring and insulin delivery devices by children and adults with type 1 diabetes over a 15-year period, with corresponding jumps in optimal blood-sugar control.

11 Aug 2025

Vital role of physical activity in early type 2 diabetes care

New research to be presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 September) shows, among people recently diagnosed with type with type 2 diabetes and no previous cardiovascular disease, a clear association exists between a person's self-reported physical activity and their risk of all-cause mortality and major adverse cardiac events (MACE), that include heart attacks and strokes.

8 Aug 2025

Early treatment withdrawal offers safety and savings for patients with rare kidney disease

Early withdrawal of a treatment for patients with a rare kidney disease is possible without relapse, safer for patients and saves the NHS millions of pounds, new research has revealed.

7 Aug 2025

CRISPR screening uncovers microproteins involved in fat storage

The obesity rate has more than doubled in the last 30 years, affecting more than one billion people worldwide.

7 Aug 2025

Study links epigenetic markers to cardiovascular risk in type 2 diabetes

People with type 2 diabetes are up to four times more likely to have heart attacks, strokes, anginas and other coronary heart diseases than healthy people.

7 Aug 2025

Suppression of cdc42 activity could be a promising therapy for nephrotic syndrome

A group led by the Department of Cell Biology at the Kidney Research Center, Niigata University revealed that elevated activity of cdc42 is a critical initiation event leading to proteinuria, and proposed that suppression of cdc42 activity could be a promising therapy for nephrotic syndrome.

6 Aug 2025

AI and extended reality successfully train surgical trainees without instructors

Mount Sinai researchers have demonstrated the effectiveness of teaching surgical trainees a difficult procedure using artificial intelligence (AI) algorithms and an extended-reality headset without the presence of an instructor.

6 Aug 2025

Kidney News and Research

New therapies for acute kidney injury show promise

Genetically-engineered immune cells show promise for preventing organ rejection

Trial finds no cardiovascular benefit and higher safety risks with spironolactone in dialysis patients

International experts recommend broader use of cardioprotective diabetes drugs

New 2025 guidelines focus on early intervention and lifestyle to manage high blood pressure

PFAS exposure increases risk of weight regain after adolescent bariatric surgery

New drug discovery platform aims to deliver first-in-class therapies

NYU Langone Hospital—Suffolk performs first robotic cancer surgeries

New research explores foot positioning to treat knee osteoarthritis

Long COVID linked to lasting financial hardship and work disruption

Study identifies biomarkers that could help predict and manage chronic kidney disease

3D-printed kidney tumors offer a new tool in the fight against renal cancer

New research highlights combined impact of genes and lifestyle on dilated cardiomyopathy

Fifteen-year study shows major gains in diabetes technology use and patient outcomes

Vital role of physical activity in early type 2 diabetes care

Early treatment withdrawal offers safety and savings for patients with rare kidney disease

CRISPR screening uncovers microproteins involved in fat storage

Study links epigenetic markers to cardiovascular risk in type 2 diabetes

Suppression of cdc42 activity could be a promising therapy for nephrotic syndrome

AI and extended reality successfully train surgical trainees without instructors

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