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Targeting HDAC2 reduces MDM2 expression and has anti-tumor effects in dedifferentiated liposarcoma

The cover for issue 55 of Oncotarget features Figure 3, "Romidepsin exhibits anti-tumor effect in xenograft model of DDLPS," by Seligson, et al.

4 Oct 2019

Scientists use organoid technology to achieve stable long-term cultures of mouse urothelial cells

Investigation of biological mechanisms in urothelial tissue -one of the three types of tissue that make up the urinary system- has always been very limited due to the lack of technologies that allow working with stable and long-term populations of the cells that compose it.

4 Oct 2019

Researchers develop 3D tissue models of brain tumors in a brain-mimicking microenvironment

A team of Tufts University-led researchers has developed three-dimensional human tissue culture models of pediatric and adult brain cancers in a brain-mimicking microenvironment, a significant advancement for the study of brain tumor biology and pharmacological response.

4 Oct 2019

Study may help in personalizing treatment for lung cancer, develop new drugs

Researchers at the University of Copenhagen have used highly sophisticated molecular analyses to identify key proteins in the signaling pathways that cancers use to spread in the body.

4 Oct 2019

UC Davis researchers awarded $1.5 million NIH grant for CRISPR cancer treatment

What if, instead of killing cancer cells or cells about to become cancerous, you could deliver a repair package and fix them? UC Davis researchers have just been awarded $1.5 million from the National Institutes of Health to start work towards that goal.

3 Oct 2019

Women under 40 often choose aggressive surgery out of fear of second breast cancer

Yes, it's not common. Breast cancer among women under 40 is rare. No matter the age, a cancer diagnosis causes anxiety and fear. In addition, women in their 20s and 30s face some unique challenges and daunting decisions. Deciding what type of surgery to have is one of them.

3 Oct 2019

New anticancer molecule shows therapeutic activity in preclinical models of various cancer types

A novel anticancer molecule created by researchers at The Wistar Institute showed therapeutic activity in preclinical models of various cancer types.

3 Oct 2019

Researchers discover metabolic vulnerability in cancer cells with mutated spliceosomes

A research team from the Johns Hopkins Kimmel Cancer Center reports it has discovered a metabolic vulnerability in multiple types of cancer cells that bear a common genetic mutation affecting cellular machines called spliceosomes.

From Johns Hopkins Medicine 3 Oct 2019

New project to examine roles of microgravity and cosmic radiation in tumor growth, development

Can weightlessness stop cancer from growing? One of the nine research projects that has been given the go-ahead for the new China Space Station scheduled for 2022 is designed to answer this exact question.

3 Oct 2019

New 3D scaffold may help identify the best treatments for cancer

A new 3D structure for growing cell cultures could enable doctors to test medications on model tumors grown from a patient's own cells, according to results from a team of engineers and cancer researchers at the University of Michigan.

3 Oct 2019

UCR biochemist receives grant to develop novel lead compound to treat breast cancer

A biochemist at the University of California, Riverside, has received a grant from the Congressionally Directed Medical Research Programs, or CDMRP, of the U.S. Department of Defense to develop a novel lead compound to treat breast cancer, the second most commonly diagnosed cancer among American women.

3 Oct 2019

Innovative compound kills cancer cells, minimizes damage to normal tissues

Most of the current clinical anti-tumor drugs used in chemotherapy move around in the patient's blood after intake and are unable to pinpoint the targeted tumor. As a result, while killing the tumor cells, the healthy cells may also be killed as "collateral damage", leading to undesired side effects.

3 Oct 2019

Adding local anesthetics can improve treatment for incurable breast cancer, melanoma

A new study examined the effects of local anesthetics combined with standard chemotherapy for treatment of incurable triple-negative breast cancer, as well as melanoma.

3 Oct 2019

Study may lead to new therapeutic methods for treating aggressive brain cancer

The research team of Miguel Hernández Univeristy (UMH) professor Salvador Martínez and the team of researcher Rut Valdor, from the University of Murcia, have showed how the glioblastoma - the most common brain cancer - "hijacks" the defensive cells that surround the blood vessels of the brain to deactivate their anti-tumour action, and forces them to work to spread the tumour.

3 Oct 2019

New algorithm can help reduce therapy for some patients with intermediate-risk neuroblastoma

A recent Children's Oncology Group study identified a treatment algorithm that can help reduce therapy for some neuroblastoma patients with intermediate-risk disease, while maintaining good clinical outcomes.

2 Oct 2019

New mechanism that controls DNA repair identified

Deoxyribonucleic acid (DNA), is the macromolecule that holds all hereditary and genetic information. Continuously under assault, alterations and damage to DNA can lead to many different health issues, including cancer.

2 Oct 2019

Certain fungi increase pancreatic cancer risk, study finds

Certain fungi move from the gut to the pancreas, expand their population more than a thousand-fold, and encourage pancreatic cancer growth, a new study finds.

2 Oct 2019

CAR T-cell therapy may be effective in killing solid tumor cells

There is now a multitude of therapies to treat cancer, from chemotherapy and radiation to immunotherapy and small molecule inhibitors. Chemotherapy is still the most widely used cancer treatment, but chemotherapy attacks all the rapidly dividing cells that it locates within the body, whether they're ultimately harmful or beneficial.

2 Oct 2019

Researchers propose potential treatment for Ewing sarcomas

Ewing sarcoma is a bone cancer that appears mainly in teenagers. Due to a single defective gene, once it spreads to distant organs it is hard to treat. Researchers at the Weizmann Institute of Science have discovered molecular interactions underlying Ewing sarcomas and proposed a potential treatment, which has shown promise in a study in mice.

2 Oct 2019

Targeted therapy slows disease progression and improves survival for prostate cancer

A new PARP-inhibitor has been shown to significantly delayed cancer progression among patients with prostate cancer who had cancer cells with faulty DNA repair genes.

2 Oct 2019

Tumor News and Research

Targeting HDAC2 reduces MDM2 expression and has anti-tumor effects in dedifferentiated liposarcoma

Scientists use organoid technology to achieve stable long-term cultures of mouse urothelial cells

Researchers develop 3D tissue models of brain tumors in a brain-mimicking microenvironment

Study may help in personalizing treatment for lung cancer, develop new drugs

UC Davis researchers awarded $1.5 million NIH grant for CRISPR cancer treatment

Women under 40 often choose aggressive surgery out of fear of second breast cancer

New anticancer molecule shows therapeutic activity in preclinical models of various cancer types

Researchers discover metabolic vulnerability in cancer cells with mutated spliceosomes

New project to examine roles of microgravity and cosmic radiation in tumor growth, development

New 3D scaffold may help identify the best treatments for cancer

UCR biochemist receives grant to develop novel lead compound to treat breast cancer

Innovative compound kills cancer cells, minimizes damage to normal tissues

Adding local anesthetics can improve treatment for incurable breast cancer, melanoma

Study may lead to new therapeutic methods for treating aggressive brain cancer

New algorithm can help reduce therapy for some patients with intermediate-risk neuroblastoma

New mechanism that controls DNA repair identified

Certain fungi increase pancreatic cancer risk, study finds

CAR T-cell therapy may be effective in killing solid tumor cells

Researchers propose potential treatment for Ewing sarcomas

Targeted therapy slows disease progression and improves survival for prostate cancer

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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